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Chemistry

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Also known as: 3380-34-5, 5-chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, Cloxifenolum, Triclosanum
Molecular Formula
C12H7Cl3O2
Molecular Weight
289.5  g/mol
InChI Key
XEFQLINVKFYRCS-UHFFFAOYSA-N
FDA UNII
4NM5039Y5X

Triclosan
A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
1 2D Structure

Triclosan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-chloro-2-(2,4-dichlorophenoxy)phenol
2.1.2 InChI
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
2.1.3 InChI Key
XEFQLINVKFYRCS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
4NM5039Y5X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,4,4'-trichloro-2'-hydroxydiphenyl Ether

2. 2-hydroxy-2',4,4'-trichlorodiphenyl Ether

3. Aquasept

4. Clearasil Daily Face Wash

5. Cliniclean

6. Dp300, Irgasan

7. Irgasan Dp 300

8. Irgasan Dp300

9. Irgasan-dp300

10. Manusept

11. Microshield T

12. Oxy Skin Wash

13. Phisohex

14. Sapoderm

15. Ster Zac Bath Concentrate

16. Ster-zac Bath Concentrate

17. Sterzac Bath Concentrate

18. Tersaseptic

19. Trisan

2.3.2 Depositor-Supplied Synonyms

1. 3380-34-5

2. 5-chloro-2-(2,4-dichlorophenoxy)phenol

3. Irgasan

4. 2,4,4'-trichloro-2'-hydroxydiphenyl Ether

5. Cloxifenolum

6. Triclosanum

7. Irgasan Dp300

8. Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-

9. Stri-dex Cleansing Bar

10. Ch 3565

11. 5-chloro-2-(2,4-dichloro-phenoxy)-phenol

12. 2,4,4'-trichloro-2'-hydroxy Diphenyl Ether

13. Chebi:164200

14. Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl

15. Phenyl Ether, 2'-hydroxy-2,4,4'-trichloro-

16. Chembl849

17. Nsc-759151

18. Ch-3565

19. 4nm5039y5x

20. Dndi1246774

21. Triclosan 10 Microg/ml In Cyclohexane

22. Tcl

23. Ncgc00159417-02

24. Ncgc00159417-05

25. Ncgc00159417-06

26. Stri-dex Face Wash

27. Aquasept

28. Sapoderm

29. Lexol 300

30. Dsstox_cid_12498

31. Dsstox_rid_78958

32. Dsstox_gsid_32498

33. Triclosanum [inn-latin]

34. Dp-300

35. Caswell No. 186a

36. Cloxifenol

37. Smr000471847

38. Cas-3380-34-5

39. Hsdb 7194

40. Triclosan (usp/inn)

41. Sr-01000762974

42. Einecs 222-182-2

43. Epa Pesticide Chemical Code 054901

44. Brn 2057142

45. Sterzac

46. Stri-dex Cleansing Bar (tn)

47. Unii-4nm5039y5x

48. Ccris 9253

49. Triclosan Usp

50. 1nhg

51. Triclosan [usan:usp:inn:ban]

52. Triclosan; Irgasan

53. Mfcd00800992

54. Irgasan Dp 30

55. Tccp

56. Neostrata Antibacterial Facial Cleanser

57. 3p9t

58. 4w9n

59. Triclosan [inn]

60. Triclosan [mi]

61. Triclosan [hsdb]

62. Triclosan [inci]

63. Triclosan [usan]

64. Triclosan [vandf]

65. Epitope Id:119683

66. Triclosan [mart.]

67. Schembl3269

68. Triclosan [usp-rs]

69. Triclosan [who-dd]

70. Mls001066347

71. Mls001074876

72. Mls001335937

73. Mls001335938

74. Bdbm8726

75. Zinc2216

76. Triclosan [orange Book]

77. Dtxsid5032498

78. Triclosan [usp Monograph]

79. Hms2093l17

80. Hms2270m06

81. Hms3259k19

82. Hms3715h11

83. Hms3872n03

84. Pharmakon1600-01505465

85. Irgasan, >=97.0% (hplc)

86. Hy-b1119

87. Tox21_111648

88. Tox21_400079

89. Dp 300

90. Nsc759151

91. S4541

92. Stl451034

93. Triclosan 100 Microg/ml In Methanol

94. Akos015850380

95. Tox21_111648_1

96. Ccg-213459

97. Ch-3635

98. Cs-4718

99. Db08604

100. Ks-5356

101. Nc00516

102. Nsc 759151

103. Colgate Total Component Triclosan

104. Ncgc00159417-03

105. Ncgc00159417-04

106. Ncgc00159417-07

107. Ncgc00159417-08

108. 2,4,4'-trichloro-2'-hydroxydiphenylethe

109. Ac-10667

110. 5-chloro-2-(2, 4-dichlorophenoxy)phenol

111. Sbi-0206807.p001

112. Triclosan Component Of Colgate Total

113. 5-chloro-2-(2,4-di-chloro-phenoxy)-phenol

114. Ft-0609773

115. T1872

116. D06226

117. D70549

118. S00100

119. 5-chloro-2-(2,4-dichlorophenoxy)phenol, 97%

120. Ab00698074_08

121. Triclosan, Antibiotic For Culture Media Use Only

122. 380t345

123. A821950

124. Q408646

125. 2-[2,4-bis(chloranyl)phenoxy]-5-chloranyl-phenol

126. Q-201866

127. Sr-01000762974-2

128. Sr-01000762974-3

129. Brd-k41731458-001-04-5

130. Brd-k41731458-001-09-4

131. Triclosan, Certified Reference Material, Tracecert(r)

132. F2173-0825

133. Triclosan, United States Pharmacopeia (usp) Reference Standard

134. Triclosan, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 289.5 g/mol
Molecular Formula C12H7Cl3O2
XLogP35
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass287.951163 g/mol
Monoisotopic Mass287.951163 g/mol
Topological Polar Surface Area29.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity252
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Anti-Infective Agents, Local; Fatty Acid Synthesis Inhibitors

National Library of Medicine's Medical Subject Headings. Triclosan. Online file (MeSH, 2017). Available from, as of November 14, 2017: https://meshb.nlm.nih.gov/search


/CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Triclosan is included in the database.

NIH/NLM; ClinicalTrials.Gov. Available from, as of November 14, 2017: https://clinicaltrials.gov/


Control of meticillin-resistant Staphylococcus aureus (MRSA) infection in surgical units has been achieved by procedures including handwashing and bathing with triclosan.

SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 1665


Triclosan is a chlorinated bisphenol antiseptic, effective against Gram-positive and most Gram-negative bacteria but with variable or poor activity against Pseudomonas spp. It is also active against fungi. It is used in soaps, creams, and solutions in concentration of up to 2% for disinfection of the hands and wounds and for disinfection of the skin prior to surgery, injections, or venepuncture. It is also used in oral hygiene products and in preparations for acne.

SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 1665


For more Therapeutic Uses (Complete) data for Triclosan (7 total), please visit the HSDB record page.


4.2 Drug Indication

Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some ANTINEOPLASTIC AGENTS and ANTI-OBESITY AGENTS and of some ANTI-INFECTIVE AGENTS which interfere with CELL WALL and CELL MEMBRANE formation. (See all compounds classified as Fatty Acid Synthesis Inhibitors.)


Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


5.2 ATC Code

D - Dermatologicals

D08 - Antiseptics and disinfectants

D08A - Antiseptics and disinfectants

D08AE - Phenol and derivatives

D08AE04 - Triclosan


D - Dermatologicals

D09 - Medicated dressings

D09A - Medicated dressings

D09AA - Medicated dressings with antiinfectives

D09AA06 - Triclosan


5.3 Absorption, Distribution and Excretion

Absorption

A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream. [PMID: 10722890] Triclosan is rapidly absorbed and distributed in the human body (Sandborgh-Englund et al., 2006). Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.


Route of Elimination

In one study, after in vivo topical application of a 64.5mM alcoholic solution of [(3)H]triclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application. [PMID: 10722890]


The number of personal hygiene products containing triclosan has increased rapidly during the last decade, and triclosan is one of the most common antibacterial compounds used in dentifrices today. However, the extent of triclosan exposure has not yet been well described. The potential risks of generating triclosan-resistant pathogenic microorganisms or of the selection of resistant strains are some areas of concern. The aim of the present study was to (1) obtain information on baseline levels of triclosan in plasma and urine, and (2) study the pharmacokinetic pattern of triclosan after a single-dose intake. Ten healthy volunteers were exposed to a single oral dose of 4 mg triclosan by swallowing an oral mouthwash solution. Triclosan in plasma and urine was followed before and up to 8 days after exposure. Triclosan levels in plasma increased rapidly, with a maximum concentration within 1 to 3 hr, and the terminal plasma half-life was 21 hr. The major fraction was excreted within the first 24 hr. The accumulated urinary excretion varied between the subjects, with 24 to 83% of the oral dose being excreted during the first 4 d after exposure. In conclusion, triclosan appears to be readily absorbed from the gastrointestinal tract and has a rapid turnover in humans. The high lipid solubility of the substance gives rise to questions regarding distribution properties and accumulation. The findings of the present study form a basis for greater understanding of the toxicokinetic properties of triclosan in humans.

PMID:16952905 Sandborgh-Englund G et al; J Toxicol Environ Health A 69 (20): 1861-73 (2006)


/MILK/ Triclosan amounts in breast milk were reported to range from <20 to 300 ug/kg lipid in one study and <5 to 2100 ug/kg lipid in another. In a study that compared triclosan levels in women who used triclosan-containing products with those who did not, levels in breast milk were 0.022 to 0.95 ug/kg lipid compared to 0.018 to 0.35 ug/kg lipid, respectively.

Cosmetic Ingredient Review; Final Report on Triclosan p.9-10 (December 14, 2010). Available from, as of November 13, 2017: https://www.cir-safety.org/ingredients


Oral and dermal routes (humans and rodents): Triclosan glucuronide is predominantly excreted in the urine, and triclosan is predominantly excreted in the feces. Triclosan that is administered orally and dermally is excreted in greater concentrations in the urine than in the feces in humans, hamsters, rabbits, and monkey. In rats, mice, and dog, the reverse is true. Up to 87% of triclosan that is administered to humans (by an unspecified route) is excreted in the urine, most of it within 72 hr after dose.

Cosmetic Ingredient Review; Final Report on Triclosan p.9 (December 14, 2010). Available from, as of November 13, 2017: https://www.cir-safety.org/ingredients


The percutaneous absorption of unlabeled triclosan was investigated in a pilot study and a 90-day study with infant Rhesus monkeys. In the pilot study, triclosan was detected in all blood samples following a single dermal exposure to a soap solution containing triclosan (1 mg/mL, 0.1%), with blood levels detected up to 24 hours, and peak levels observed at 8 to 12 hours. In the 90-day study, only the glucuronide and sulfate conjugates were detected in blood samples, the glucuronide predominating in the early blood samples (Days 1 to 2), and triclosan sulfate predominating in all subsequent blood samples (samples were taken daily for the 90-day duration of the study). Triclosan was excreted in the urine primarily as the glucuronide conjugate, but was excreted in the feces primarily in the free or unconjugated form. Low levels of triclosan were detected in tissues. The results of this monkey study indicate that triclosan was absorbed percutaneously following 90 days of daily washing with 15 mL of soap (1 mg triclosan/mL) and that the proportion of plasma glucuronide and sulfate conjugates altered following chronic administration.

European Commission; Scientific Committee on Consumer Products (SCCP) - Opinion on Triclosan; SCCP/1192/08 p.20 (January 21, 2009). Available from, as of November 13, 2017: https://ec.europa.eu/health/scientific_committees/consumer_safety/opinions/sccp_opinions_en#6


For more Absorption, Distribution and Excretion (Complete) data for Triclosan (14 total), please visit the HSDB record page.


5.4 Metabolism/Metabolites

Triclosan is prone to phase II metabolism via sulfotransferase and glucuronosyltransferase enzymes (Wang et al., 2004). In humans the resulting conjugates are excreted primarily in urine (Sandborgh-Englund et al., 2006).


Oral and dermal routes (humans and rodents): Triclosan absorbed from the gastrointestinal tract undergoes extensive first-pass metabolism, which primarily involves glucuronide and sulfate conjugation. In both humans and rodents, at high triclosan plasma concentrations, metabolism shifts from the generation of predominantly glucuronide conjugates to sulfate-conjugates. The bioavailability of unconjugated triclosan may be limited after oral exposure because of triclosan's extensive first-pass metabolism. Triclosan is also metabolized to its glucuronide and sulfate conjugates by the skin.

Cosmetic Ingredient Review; Final Report on Triclosan p.9 (December 14, 2010). Available from, as of November 13, 2017: https://www.cir-safety.org/ingredients


Triclosan has been widely used as a disinfectant in human health care products. Although this particular chemical is less toxic, its biotransformation products might have toxicity to human. Therefore, understanding the pharmacokinetics and metabolism of triclosan in animal and human body is important. Plasma samples from SD rats collected after the oral administration of 5 mg/kg triclosan were analyzed ... . The pharmacokinetic data of triclosan in the rats were presented including the half time of elimination that was (48.5 +/- 10.5) hr, indicating that the elimination of triclosan in the rat was slow. Two hydroxylated and sulfonated triclosan, one glucuronidated triclosan, and one sulfonated triclosan were identified in the rat plasma samples.

PMID:20073210 Wu J et al; Se Pu 27 (5): 724-30 (2009)


...Irgasan DP 300 is excreted unchanged in feces and urine (partly conjugated) but is also hydroxylated to five different monohydroxy metabolites which were found in urine; three of these were also present in feces.

PMID:433312 Tulp MTM et al; Xenobiotica 9 (2): 65-77 (1979)


Triclosan has known human metabolites that include (2S,3S,4S,5R)-6-[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid and Triclosan sulfate.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.5 Biological Half-Life

The terminal plasma half life of triclosan is 21 h (Sandborgh-Englund et al., 2006).


Measurements of the oral retention and pharmacokinetics of (3)H-triclosan delivered from a toothpaste containing 0.2% (3)H-triclosan were made in 12 human volunteers (aged 19-37 yr). ... After use of a one g quantity of the toothpaste, 36.3+-1.4% of the (3)H-triclosan was retained. ... The saliva decay curve for (3)H-triclosan was consistent with a 2 phase model with half life values of 0.45 hr and 2.42 hr, respectively. ...

PMID:3593627 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386194 Gilbert RJ et al; Br J Clin Pharmacol 23: 579-583 (1987)


... Ten healthy volunteers were exposed to a single oral dose of 4 mg triclosan by swallowing an oral mouthwash solution. Triclosan in plasma and urine was followed before and up to 8 days after exposure. Triclosan levels in plasma increased rapidly, with a maximum concentration within 1 to 3 hr, and the terminal plasma half-life was 21 hr. ...

PMID:16952905 Sandborgh-Englund G et al; J Toxicol Environ Health A 69 (20): 1861-73 (2006)


The blood half-life of (14)C-triclosan during the beta-phase was 8.8 +/- 0.6 hr and the blood clearance rate was 77.5 +/- 11.3 mL/kg/hr /after injection either via the femoral vein, (iv, 5 mg/kg in polyethylene glycol-400) or into the vaginal orifice (ivg, 5 mg/kg in corn oil)/ .

PMID:422939 Siddiqui WH et al; J Environ Pathol Toxicol 2 (3): 861-71 (1979)


Plasma samples from SD rats collected after the oral administration of 5 mg/kg triclosan were analyzed ... . The pharmacokinetic data of triclosan in the rats were presented including the half time of elimination that was (48.5 +/- 10.5) hr, indicating that the elimination of triclosan in the rat was slow. Two hydroxylated and sulfonated triclosan, one glucuronidated triclosan, and one sulfonated triclosan were identified in the rat plasma samples.

PMID:20073210 Wu J et al; Se Pu 27 (5): 724-30 (2009)


5.6 Mechanism of Action

Triclosan is a biocidal compound with multiple targets in the cytoplasm and membrane. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to enoyl-acyl carrier protein reductase enzyme (ENR). This complex has increased affinity for NAD+ and forms a ternary complex. This complex is unable to participate in fatty acid synthesis, weakening the cell membrane and causing cell death. Humans do not have an ENR enzyme, and thus are not affected.


Triclosan (TCS) exposure has widely adverse biological effects such as influencing biological reproduction and endocrine disorders. While some studies have addressed TCS-induced expression changes of miRNAs and their related down-stream target genes, no data are available concerning how TCS impairs miRNA expression leading us to study up-stream regulating mechanisms. Four miRNAs (miR-125b, miR-205, miR-142a and miR-203a) showed differential expression between TCS-exposure treatments and the control group; their functions mainly involved fatty acid synthesis and metabolism. TCS exposure led to the up-regulation of mature miR-125b that was concomitant with consistent changes in pri-mir-125b-1 and pri-mir-125b-3 among its 3 pri-mir-125bs. Up-regulation of miR-125b originated from direct shear processes involving the two up-regulated precursors, but not pri-mir-125b2. Increased expression of pri-mir-125b-1 and pri-mir-125b-3 resulted from nfe2l2- and c/ebpa-integration with positive control elements of promoters for the two precursors. The overexpression of transcriptional factors, nfe2l2 and c/ebpa, initiated the promoter activity for the miR-125b precursor. CpG islands and Nfe2l2 were involved in constitutive expression of mir-125b-1 and mir-125b-3. The activities of two promoter regions, -487 to -1bp for pri-mir-125b1 and -1327 to +14bp for pri-mir-125b-3 having binding sites for NFE2 and Nfe2l2/MAF:NFE2, were higher than other regions, further demonstrating that the transcriptional factor Nfe2l2 was involved in the regulation of pri-mir-125b1 and pri-mir-125b-3. TCS's estrogen activity resulted from its effects on GPER, a novel membrane receptor, rather than the classical ERa and ERbeta. These results explain, to some extent, the up-stream mechanism for miR-125b up-regulation, and also provide a guidance to future mechanistic study on TCS-exposure.

PMID:29121543 Lin J et al; Aquat Toxicol 193: 256-267 (2017)


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Triclosan USP

Date of Issue : 2021-02-12

Valid Till : 2024-01-28

Written Confirmation Number : WC-0238

Address of the Firm : Plot No.36, Road No. 3& 5, Jigani Industrial Area, Anekal Taluk, Bangalore-56010...

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TRICLOSAN

NDC Package Code : 63934-110

Start Marketing Date : 2000-01-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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Triclosan

About the Company : Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opp...

Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opportunities grew, it was felt that the proprietorship firm had outlived its usefulness and that it needed a corporate structure. So, Tenatra Chemie Private Limited (TCPL) was incorporated in 2002. Since then, the company has come a long way, gaining valuable experience and knowledge in the fields of chemicals and pharmaceuticals in India.
Tenatra

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Triclosan

About the Company : Shreeneel Chemicals is dedicated to quality healthcare development and fostering a knowledgeable environment. The company was founded by Mr. Sanjay Tavethiya and Mr. Anoopsingh Tom...

Shreeneel Chemicals is dedicated to quality healthcare development and fostering a knowledgeable environment. The company was founded by Mr. Sanjay Tavethiya and Mr. Anoopsingh Tomar in late 2010, following their collaboration as colleagues for half a decade and extensive experience in soft floor operations. Our commitment to quality in both products and work practices has earned us a wide range of clients. Embracing the philosophy of "vasudhaiva kutumbakam" (the world is a family), we treat our customers and team members like family, prioritizing quality relationships over quantity.
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","customerCountry":"COLOMBIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"18.5","totalValueFC":"18322.1","currency":"N\/A","unitRateINR":1579.90003,"date":"31-Jan-2025","totalValueINR":"1579900.03","totalValueInUsd":"18322.1","indian_port":"JNPT","hs_no":"29095090","bill_no":"7772523","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COLOMBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"PLOT.NO.36B,USHA KRISHNA TOWER ROAD, ANEKAL TQ,BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738780200,"product":"WE INTEND TO CLAIM REWARDS UNDER (RODTEP). 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TENJO CUNDINAMARCA BOGOTA \/ C Colombia","customerAddress":"PLOT.NO.36B,USHA KRISHNA TOWER ROAD"}]
02-Jan-2021
28-Feb-2025
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ABOUT THIS PAGE

Looking for 3380-34-5 / Triclosan API manufacturers, exporters & distributors?

Triclosan manufacturers, exporters & distributors 1

38

PharmaCompass offers a list of Triclosan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Triclosan manufacturer or Triclosan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Triclosan manufacturer or Triclosan supplier.

PharmaCompass also assists you with knowing the Triclosan API Price utilized in the formulation of products. Triclosan API Price is not always fixed or binding as the Triclosan Price is obtained through a variety of data sources. The Triclosan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Triclosan

Synonyms

3380-34-5, 5-chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, Cloxifenolum, Triclosanum

Cas Number

3380-34-5

Unique Ingredient Identifier (UNII)

4NM5039Y5X

About Triclosan

A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.

Triclosan Manufacturers

A Triclosan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Triclosan, including repackagers and relabelers. The FDA regulates Triclosan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Triclosan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Triclosan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Triclosan Suppliers

A Triclosan supplier is an individual or a company that provides Triclosan active pharmaceutical ingredient (API) or Triclosan finished formulations upon request. The Triclosan suppliers may include Triclosan API manufacturers, exporters, distributors and traders.

click here to find a list of Triclosan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Triclosan USDMF

A Triclosan DMF (Drug Master File) is a document detailing the whole manufacturing process of Triclosan active pharmaceutical ingredient (API) in detail. Different forms of Triclosan DMFs exist exist since differing nations have different regulations, such as Triclosan USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Triclosan DMF submitted to regulatory agencies in the US is known as a USDMF. Triclosan USDMF includes data on Triclosan's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Triclosan USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Triclosan suppliers with USDMF on PharmaCompass.

Triclosan WC

A Triclosan written confirmation (Triclosan WC) is an official document issued by a regulatory agency to a Triclosan manufacturer, verifying that the manufacturing facility of a Triclosan active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Triclosan APIs or Triclosan finished pharmaceutical products to another nation, regulatory agencies frequently require a Triclosan WC (written confirmation) as part of the regulatory process.

click here to find a list of Triclosan suppliers with Written Confirmation (WC) on PharmaCompass.

Triclosan NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Triclosan as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Triclosan API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Triclosan as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Triclosan and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Triclosan NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Triclosan suppliers with NDC on PharmaCompass.

Triclosan GMP

Triclosan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Triclosan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Triclosan GMP manufacturer or Triclosan GMP API supplier for your needs.

Triclosan CoA

A Triclosan CoA (Certificate of Analysis) is a formal document that attests to Triclosan's compliance with Triclosan specifications and serves as a tool for batch-level quality control.

Triclosan CoA mostly includes findings from lab analyses of a specific batch. For each Triclosan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Triclosan may be tested according to a variety of international standards, such as European Pharmacopoeia (Triclosan EP), Triclosan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Triclosan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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