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Trientine Hydrochloride

Nuray Trientine HCL

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Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 13 USDMF, 1 JDMF, 8 EU WC, 11 NDC API, 12 Listed Suppliers, $ API Reference Price

23 API Suppliers
13 USDMF
1 JDMF
8 EU WC
11 NDC API
12 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

30 FDF Dossiers, 16 FDA Orange Book, 5 Europe, 2 Canada, 2 Australia, 5 Listed Dossiers

30 FDF Dossiers
16 FDA Orange Book
5 Europe
2 Canada
2 Australia
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

7 DKSH, 1 Nanjing Well Pharmaceutical, 4 ACG Worldwide, 3 BASF, 1 Finar, 2 Gangwal Chemicals, 3 Lonza Capsugel, 2 Microlex e.U, 1 Qualicaps, 4 Roquette, 1 Seppic, 1 Valens Pharmachem

relatedExcipients
7 DKSH
1 Nanjing Well Pharmaceutical
4 ACG Worldwide
3 BASF
1 Finar
2 Gangwal Chemicals
3 Lonza Capsugel
2 Microlex e.U
1 Qualicaps
4 Roquette
1 Seppic
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

9 Coating Systems & Additives, 8 Empty Capsules, 7 Film Formers & Plasticizers, 6 Thickeners and Stabilizers, 6 Fillers, Diluents & Binders, 4 Topical, 3 Lubricants & Glidants, 3 Coloring Agents, 2 Solubilizers, 1 Emulsifying Agents, 1 Parenteral, 1 Granulation, 1 Taste Masking, 1 Direct Compression

excipientsByApplications
9 Coating Systems & Additives
8 Empty Capsules
7 Film Formers & Plasticizers
6 Thickeners and Stabilizers
6 Fillers, Diluents & Binders
4 Topical
3 Lubricants & Glidants
3 Coloring Agents
2 Solubilizers
1 Emulsifying Agents
1 Parenteral
1 Granulation
1 Taste Masking
1 Direct Compression

DIGITAL CONTENT

13 NEWS #PharmaBuzz

media
13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 4 Finished Drug Prices, 3 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
4 Finished Drug Prices
3 Annual Reports

MARKET PLACE

7 APIs, 4 FDF Dossiers

marketPlace
7 APIs
4 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Nuray Trientine HCL

Synopsis

ACTIVE PHARMA INGREDIENTS

23

API Suppliers

13

USDMF

0

CEP/COS

CEP/COS Certifications

1

JDMF

8

EU WC

0

KDMF

11

NDC API

0

VMF

12

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 2,619

MARKET PLACE

7

API

4

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

30

FDF Dossiers

16

FDA Orange Book

FDA (Orange Book)

5

Europe

2

Canada

2

Australia

0

South Africa

5

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

1

USP

0

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

13

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

6,205,272

Annual Reports (USD Million)

226

Finished Drug Prices

30 RELATED EXCIPIENT COMPANIES

53EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Triethylenetetramine dihydrochloride, 38260-01-4, Syprine, Trientine dihydrochloride, Trientine hcl, Mk-0681

Molecular Formula

C₆H₂₀Cl₂N₄

Molecular Weight

219.15 g/mol

InChI Key

WYHIICXRPHEJKI-UHFFFAOYSA-N

FDA UNII

HC3NX54582

Trientine Hydrochloride

An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.

1 2D Structure

Trientine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride

2.1.2 InChI

InChI=1S/C6H18N4.2ClH/c7-1-3-9-5-6-10-4-2-8;;/h9-10H,1-8H2;2*1H

2.1.3 InChI Key

WYHIICXRPHEJKI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C(CNCCNCCN)N.Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

HC3NX54582

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Syprine

2. Trien

3. Trientine

4. Trientine Dihydrochloride

5. Triethylenetetramine

2.3.2 Depositor-Supplied Synonyms

1. Triethylenetetramine Dihydrochloride

2. 38260-01-4

3. Syprine

4. Trientine Dihydrochloride

5. Trientine Hcl

6. Mk-0681

7. 1,2-ethanediamine, N,n'-bis(2-aminoethyl)-, Dihydrochloride

8. Triethylene Tetramine Dihydrochloride

9. Teta

10. N,n'-bis(2-aminoethyl)-1,2-ethanediamine Dihydrochloride

11. Hc3nx54582

12. Nsc-759164

13. N1,n1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine) Dihydrochloride

14. Trien Dihydrochloride

15. Cuprid

16. 1,2-ethanediamine,n1,n2-bis(2-aminoethyl)-, Hydrochloride (1:2)

17. Trientine Hydrochloride [usan]

18. Einecs 253-854-3

19. Mk 0681

20. N,n'-bis(2-aminoethyl)ethylenediamine Dihydrochloride

21. Laszarin

22. Metalite

23. Unii-hc3nx54582

24. Trientine-2hcl

25. 2,2'-ethylenediiminobis(ethylamine) Dihydrochloride

26. Syprine (tn)

27. Trientine Hydrochloride [usan:usp]

28. Trientinedihydrochloride

29. Triethyl Enetetramine 2hcl

30. Schembl506189

31. Chebi:9706

32. Chembl3989777

33. Dtxsid2057863

34. Amy3335

35. Tja-250

36. Mk-681

37. N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride

38. S6585

39. Trientine Hydrochloride (jp17/usp)

40. Trientine Hydrochloride [jan]

41. Trientine Dihydrochloride [mi]

42. Akos028109579

43. Ccg-213505

44. Nsc 759164

45. Trientine Hydrochloride [vandf]

46. Trientine Hydrochloride [usp-rs]

47. Trientine Dihydrochloride [mart.]

48. Bs-49370

49. Trientine Dihydrochloride [who-dd]

50. Db-049259

51. Ft-0639448

52. Trientine Hydrochloride [orange Book]

53. D00736

54. E78246

55. Trientine Hydrochloride [usp Monograph]

56. 260t014

57. Q27279855

58. N1,n1'-(ethane-1,2-diyl)diethane-1,2-diamine Dihydrochloride

59. N\'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine,dihydrochloride

60. Trientine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

61. Triethylenetetramine Dihydrochloride, Puriss., 2xcryst., >=99.0% (at)

62. Trientine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₆H₂₀Cl₂N₄
Molecular Weight	219.15 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	218.1065020 g/mol
Monoisotopic Mass	218.1065020 g/mol
Topological Polar Surface Area	76.1 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	49.7
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Syprine
PubMed Health	Trientine (By mouth)
Drug Classes	Heavy Metal Chelator
Drug Label	Trientine hydrochloride is N,N'-bis (2-aminoethyl)-1,2-ethanediamine dihydrochloride. It is a white to pale yellow crystalline hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chlor
Active Ingredient	Trientine hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	250mg
Market Status	Prescription
Company	Aton

2 of 2
Drug Name	Syprine
PubMed Health	Trientine (By mouth)
Drug Classes	Heavy Metal Chelator
Drug Label	Trientine hydrochloride is N,N'-bis (2-aminoethyl)-1,2-ethanediamine dihydrochloride. It is a white to pale yellow crystalline hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chlor
Active Ingredient	Trientine hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	250mg
Market Status	Prescription
Company	Aton

4.2 Drug Indication

Cufence is indicated for the treatment of Wilsons disease in patients intolerant to D-Penicillamine therapy, in adults and children aged 5 years or older.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Metal Chelator [EPC]; Metal Chelating Activity [MoA]

5.3 ATC Code

A16A

API SUPPLIERS

01

Nuray Chemicals Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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India

Digital Content

USDMF

Click Us!

CEP/COS JDMF EU-WC

NDC

KDMF VMF Others AUDIT

Nuray Chemicals

Product Web Link

Digital Content

02

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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U.S.A

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Chemwerth Compnay Banner

Product Web Link

Digital Content

03

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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India

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

04

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU

AUDIT

HRV Global Life Sciences

Product Web Link

Digital Content

05

BrightGene Bio-Medical Technology ...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

06

Dasami Lab

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

07

MSN Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

08

Emcure Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

09

Viatris

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

10

ORGANICA Feinchemie GmbH Wolfen

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

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USDMF

01

Ss Pharma Llc

India

CPhI India 2024

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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India

Digital Content

Trientine Hydrochloride Usp

GDUFA

DMF Review : Complete

Rev. Date : 2016-12-23

Pay. Date : 2016-09-13

DMF Number : 30878

Submission : 2016-11-08

Status : Active

Type : II

Nuray Chemicals

Product Web Link

Digital Content

02

Chemwerth Inc

U.S.A

Compamed

Not Confirmed

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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U.S.A

Digital Content

Trientine Hydrochloride Usp

GDUFA

DMF Review : Complete

Rev. Date : 2015-12-15

Pay. Date : 2015-09-21

DMF Number : 29019

Submission : 2015-09-25

Status : Active

Type : II

Chemwerth Compnay Banner

Product Web Link

Digital Content

03

Biophore India Pharmaceuticals Pvt L...

India

CPhI India 2024

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

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India

Digital Content

Trientine Hydrochloride

GDUFA

DMF Review : Complete

Rev. Date : 2016-03-01

Pay. Date : 2015-09-15

DMF Number : 29527

Submission : 2015-09-03

Status : Active

Type : II

Product Web Link

Digital Content

04

Teva Pharmaceutical Industries Ltd

Ireland

Compamed

Not Confirmed

05

Navinta Llc

India

Compamed

Not Confirmed

06

Curia New York Inc

U.S.A

Compamed

Not Confirmed

07

Emcure Pharmaceuticals Ltd

India

Compamed

Not Confirmed

08

Msn Organics Private Ltd

India

Compamed

Not Confirmed

09

Organichem Corp

Germany

Compamed

Not Confirmed

10

Suven Pharmaceuticals Ltd

India

Compamed

Not Confirmed

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EU WC

01

Nuray Chemicals Private Limited

India

CPhI India 2024

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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Digital Content

Trientine Hydrochloride USP

Date of Issue : 2024-02-20

Valid Till : 2026-12-06

Written Confirmation Number : WC-0416

Address of the Firm : Plot No. 111 SIDCO Industrial Estate, Kakkalur Thiruvallur-602003 Tamil Nadu, In...

Nuray Chemicals

Product Web Link

Digital Content

02

Apothecon Pharmaceuticals

India

The Pharmacy Technology

Not Confirmed

03

Azico Biophore India Pvt. Ltd

India

The Pharmacy Technology

Not Confirmed

04

Azico Biophore India Pvt. Ltd

India

The Pharmacy Technology

Not Confirmed

05

Emcure Pharmaceuticals

India

The Pharmacy Technology

Not Confirmed

06

MSN Laboratories

India

The Pharmacy Technology

Not Confirmed

07

MSN Laboratories

India

The Pharmacy Technology

Not Confirmed

08

Suven Life Sciences Limited

India

The Pharmacy Technology

Not Confirmed

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API Reference Price

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MANAGER","customerCountry":"TURKEY","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"2000","totalValueFC":"46446.3","currency":"USD","unitRateINR":127866.66666666667,"date":"03-Feb-2023","totalValueINR":"3836000","totalValueInUsd":"46446.3","indian_port":"MADRAS AIR","hs_no":"29212990","bill_no":"7516935","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRAS AIR","supplierAddress":"FIRST FLOOR SFNO.534\/4A2B NO 102 SAMY APARTMENT, CHENNAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678645800,"product":"PHARMACEUTICAL RAW MATERIAL TRIENTINE HY","address":"312 NILKANTH PALACE 100 ROAD,SATEL LITE JODHPUR","city":"AHMEDABAD GUJARAT INDIA,GUJARAT","supplier":"JIVITA HEALTHCARE PRIVATE ","supplierCountry":"INDIA","foreign_port":"COLOMBO","customer":"CELOGEN LANKA PVT ","customerCountry":"SRI LANKA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"6941","totalValueFC":"55185.2","currency":"USD","unitRateINR":567375,"date":"13-Mar-2023","totalValueINR":"4539000","totalValueInUsd":"55185.2","indian_port":"BOMBAY AIR","hs_no":"29212990","bill_no":"8428737","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SRI LANKA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"312 NILKANTH PALACE 100 ROAD,SATEL LITE JODHPUR, AHMEDABAD GUJARAT INDIA,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709749800,"product":"PHARMACEUTICAL RAW MATERIAL TRIENTINE HYDROCHLORIDE USP BATCH NO.:1TRN323001 MFGDT. 17 FEB 23 RETEST 16 FEB 2026","address":"T-184, MIDC, BHOSARI,","city":"PUNE-MAHARASHTRA","supplier":"EMCURE PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"MERKO PHARMACEUTICAL & CHEMICAL 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LTD","supplierCountry":"INDIA","foreign_port":"ANKARA","customer":"GEN ILAC VE ","customerCountry":"TURKEY","quantity":"305.76","actualQuantity":"305.76","unit":"KGS","unitRateFc":"1500","totalValueFC":"453016","currency":"USD","unitRateINR":124275,"date":"10-Aug-2024","totalValueINR":"37998324","totalValueInUsd":"453016","indian_port":"Hyderabad Air","hs_no":"29212990","bill_no":"3106073","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"425\/3RT, D.NO.7-1-621\/328, SANJEEVAREDDY NAGAR,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724869800,"product":"TRIENTINE HYDROCHLORIDE USP BATCH NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"USP","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0004","unit":"KGS","unitRateFc":"1285000","totalValueFC":"531.3","currency":"USD","unitRateINR":"105612775","date":"21-Jul-2022","totalValueINR":"42245.11","totalValueInUsd":"531.3","indian_port":"HYDERABAD AIR","hs_no":"29212990","bill_no":"9647527","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Tobio Novelfarma

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Future Health Pharma GmbH

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