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    Also known as: Triethanolamine salicylate, 2174-16-5, Tea-salicylate, Neo heliopan ts, Tea salicylate, Neotan w
    Molecular Formula
    C13H21NO6
    Molecular Weight
    287.31  g/mol
    InChI Key
    UEVAMYPIMMOEFW-UHFFFAOYSA-N
    FDA UNII
    H8O4040BHD
    Triethanolamine Salicylate
    Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains.
    1 2D Structure

    Triethanolamine Salicylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid
    2.1.2 InChI
    InChI=1S/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)10;8-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10);8-10H,1-6H2
    2.1.3 InChI Key
    UEVAMYPIMMOEFW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C(=C1)C(=O)O)O.C(CO)N(CCO)CCO
    2.2 Other Identifiers
    2.2.1 UNII
    H8O4040BHD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Myoflex

    2. Triethanolamine Salicylate

    2.3.2 Depositor-Supplied Synonyms

    1. Triethanolamine Salicylate

    2. 2174-16-5

    3. Tea-salicylate

    4. Neo Heliopan Ts

    5. Tea Salicylate

    6. Neotan W

    7. Salicylic Acid Trolamine

    8. H8o4040bhd

    9. 2-hydroxybenzoic Acid, Compd. With 2,2',2''-nitrilotris(ethanol) (1:1)

    10. Trolamine Salicylate (usp)

    11. Trolamine Salicylate [usp]

    12. Benzoic Acid, 2-hydroxy-, Compd. With 2,2',2''-nitrilotris(ethanol) (1:1)

    13. Arthricream

    14. Myoflex

    15. Sunarome W

    16. Benzoic Acid, 2-hydroxy-, Compd. With 2,2',2''-nitrilotris[ethanol] (1:1)

    17. Arthricream (tn)

    18. Dsstox_cid_27945

    19. Dsstox_rid_82697

    20. Unii-h8o4040bhd

    21. Dsstox_gsid_47969

    22. Schembl15847

    23. Salicylic Acid Triethanolamine

    24. Tea-salicylate [inci]

    25. Chembl2107288

    26. Dtxsid4047969

    27. 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic Acid

    28. Triethanolamine, Salicylate

    29. Salicylic Acid Triethanolamine Salt

    30. Einecs 218-531-3

    31. Tox21_201084

    32. Trolamine Salicylate [mart.]

    33. Trolamine Salicylate [who-dd]

    34. Db11079

    35. Triethanolamine Salicylate [mi]

    36. Ncgc00248985-01

    37. Ncgc00258636-01

    38. Triethanolamine Salicylate [vandf]

    39. Cas-2174-16-5

    40. Trolamine Salicylate [usp Impurity]

    41. Trolamine Salicylate [usp Monograph]

    42. Ft-0708839

    43. 2,2',2''-nitrilotriethanol 2-hydroxybenzoate

    44. D08501

    45. Q7845153

    46. Salicylic Acid, Compound With 2,2',2''-nitrilotriethanol (1:1)

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 287.31 g/mol
    Molecular Formula C13H21NO6
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass287.13688739 g/mol
    Monoisotopic Mass287.13688739 g/mol
    Topological Polar Surface Area122 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity189
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation. It is thought to mediate its analgesic effect through inhibition of COX-2 enzyme, which is an induced enzyme responsible for inflammatory responses and pain in muscle and joint disorders. By inhibiting fatty acid COX enzyme, trolamine salicylate inhibits the production of prostaglandins and thromboxanes in inflammatory cells involved in generating pain and inflammation. It thereby works to temporarily reduce mild to moderate pain. In subjects with muscle soreness from exercise, administration of topical trolamine salicylate was associated with reduced duration and severity of muscule soreness compared to placebo. In subjects with osteoarthritis in hands, trolamine salicylate cream was shown to be effective in achieving temporary relief of minor pain and stiffness.

    5.2 Absorption, Distribution and Excretion

    Absorption

    Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption.

    Route of Elimination

    Following topical administration of 10% trolamine salicylate in healthy volunteers, urinary recovery of total salicylate during the first 24 hours was 6.9 mg (p < 0.05), which is 1.4% of total dose.

    Volume of Distribution

    Topical administration of 1 gram of 10% trolamine salicylate in abdominal rat skin resulted in an approximate extravascular volume of distribution (V/F) of 24.0 mL.

    5.3 Mechanism of Action

    Inflammation and tissue damage in different conditions including arthritis, bursitis, joint disorder, bruises, and strains or sprains of muscle origin, induce mild to moderate pain and are associated with increase prostaglandin synthesis. This is thought to be a result of COX-2 enzyme induction. COX-2 is induced in inflammatory cells in case of cell injury, infection or activation from inflammatory cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-. Upon activation, COX-2 produces prostanoid mediators of inflammation such as prostaglandins and thromboxanes. Trolamine salicylate mediates its analgesic effect by inhibiting the production of inflammatory mediators that sensitize nociceptive nerve endings and generate pain.

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    Looking for 2174-16-5 / Triethanolamine Salicylate API manufacturers, exporters & distributors?

    Triethanolamine Salicylate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Triethanolamine Salicylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Triethanolamine Salicylate manufacturer or Triethanolamine Salicylate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Triethanolamine Salicylate manufacturer or Triethanolamine Salicylate supplier.

    PharmaCompass also assists you with knowing the Triethanolamine Salicylate API Price utilized in the formulation of products. Triethanolamine Salicylate API Price is not always fixed or binding as the Triethanolamine Salicylate Price is obtained through a variety of data sources. The Triethanolamine Salicylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Triethanolamine Salicylate

    Synonyms

    2174-16-5, Tea-salicylate, Neo heliopan ts, Tea salicylate, Neotan w, Salicylic acid trolamine

    Cas Number

    2174-16-5

    Unique Ingredient Identifier (UNII)

    H8O4040BHD

    About Triethanolamine Salicylate

    Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains.

    Triethanolamine Salicylate Manufacturers

    A Triethanolamine Salicylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Triethanolamine Salicylate, including repackagers and relabelers. The FDA regulates Triethanolamine Salicylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Triethanolamine Salicylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Triethanolamine Salicylate Suppliers

    A Triethanolamine Salicylate supplier is an individual or a company that provides Triethanolamine Salicylate active pharmaceutical ingredient (API) or Triethanolamine Salicylate finished formulations upon request. The Triethanolamine Salicylate suppliers may include Triethanolamine Salicylate API manufacturers, exporters, distributors and traders.

    Triethanolamine Salicylate GMP

    Triethanolamine Salicylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Triethanolamine Salicylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Triethanolamine Salicylate GMP manufacturer or Triethanolamine Salicylate GMP API supplier for your needs.

    Triethanolamine Salicylate CoA

    A Triethanolamine Salicylate CoA (Certificate of Analysis) is a formal document that attests to Triethanolamine Salicylate's compliance with Triethanolamine Salicylate specifications and serves as a tool for batch-level quality control.

    Triethanolamine Salicylate CoA mostly includes findings from lab analyses of a specific batch. For each Triethanolamine Salicylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Triethanolamine Salicylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Triethanolamine Salicylate EP), Triethanolamine Salicylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Triethanolamine Salicylate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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