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Chemistry

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Also known as: Trifluoperazine dihydrochloride, 440-17-5, Stelazine, Trifluoperazine 2hcl, Terfluzine, Trifluoperazine hcl
Molecular Formula
C21H26Cl2F3N3S
Molecular Weight
480.4  g/mol
InChI Key
BXDAOUXDMHXPDI-UHFFFAOYSA-N
FDA UNII
6P1Y2SNF5V

Trifluoperazine Dihydrochloride
A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
1 2D Structure

Trifluoperazine Dihydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride
2.1.2 InChI
InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
2.1.3 InChI Key
BXDAOUXDMHXPDI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
6P1Y2SNF5V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo Trifluoperazine

2. Apo-trifluoperazine

3. Apotrifluoperazine

4. Eskazine

5. Flupazine

6. Stelazine

7. Terfluzine

8. Trifluoperazine

9. Trifluoperazine Hcl

10. Trifluoroperazine

11. Trifluperazine

12. Triftazin

2.3.2 Depositor-Supplied Synonyms

1. Trifluoperazine Dihydrochloride

2. 440-17-5

3. Stelazine

4. Trifluoperazine 2hcl

5. Terfluzine

6. Trifluoperazine Hcl

7. Triphthazine

8. Eskazinyl

9. Jatroneural

10. Triftazin

11. Tryptazine

12. Trazine

13. Trifluoroperazine Hydrochloride

14. Tryptazine Dihydrochloride

15. Fluoperazine

16. Eskazine

17. Triphthazine Dihydrochloride

18. Calmazine

19. Modalina

20. Stalazine Hydrochloride

21. Trifluoroperazine Dihydrochloride

22. Stelazine Dihydrochloride

23. Trifluoperazine (dihydrochloride)

24. Skf 5019

25. Trifluperazine Dihydrochloride

26. 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10h-phenothiazine Dihydrochloride

27. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10h-phenothiazine Dihydrochloride

28. Fluoperazine Dihydrochloride

29. 6p1y2snf5v

30. 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine Dihydrochloride

31. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride

32. 10h-phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, Dihydrochloride

33. Nsc-757369

34. 10h-phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, Dihydrochloride

35. Dsstox_cid_25085

36. Dsstox_rid_80660

37. Dsstox_gsid_45085

38. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine Dihydrochloride

39. Chebi:9710

40. Sr-01000003020

41. Ncgc00186653-01

42. Trifluoperazine Hydrochloride (van)

43. Trifluoperazine Hydrochloride [jan]

44. Cas-440-17-5

45. Einecs 207-123-0

46. Unii-6p1y2snf5v

47. Triphthasine

48. Ai3-50137

49. Stelazine (tn)

50. Prestwick_482

51. Mfcd00012656

52. Trifluoperazine Dihcl

53. Trifluoperazine Hydrochloride [usp:jan]

54. Schembl341516

55. Spectrum1500591

56. Chembl1257040

57. Dtxsid1045085

58. Hy-b0532a

59. Skf5019

60. Hms1568p08

61. Hms1921g15

62. Skf-5019

63. Tox21_110017

64. Tox21_501232

65. Ccg-40290

66. S3201

67. Akos015895085

68. Tox21_110017_1

69. Ac-8081

70. Ks-5109

71. Lp01232

72. Sb19410

73. Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, Dihydrochloride

74. Ncgc00013226-01

75. Ncgc00094474-01

76. Ncgc00094474-02

77. Ncgc00094474-03

78. Ncgc00261917-01

79. Trifluoperazine Hydrochloride (jan/usp)

80. Trifluoperazine Dihydrochloride, >/=99%

81. Trifluoperazine Dihydrochloride [mi]

82. Eu-0101232

83. Ft-0600798

84. Sw168675-6

85. T-175

86. T2849

87. Trifluoperazine Hydrochloride [mart.]

88. Trifluoperazine Hydrochloride [vandf]

89. Trifluoperazine Hydrochloride [usp-rs]

90. Trifluoperazine Hydrochloride [who-dd]

91. C75189

92. D00799

93. T 8516

94. Trifluoperazine Dihydrochloride, >=99%, Powder

95. A826478

96. Trifluoperazine Hydrochloride [orange Book]

97. Sr-01000003020-2

98. Trifluoperazine Hydrochloride [ep Monograph]

99. Trifluoperazine Hydrochloride [usp Monograph]

100. W-106212

101. Q27108478

102. Sr-01000003020-10

103. Trifluoperazine Hydrochloride, Meets Usp Testing Specifications

104. Trifluoperazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

105. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride.

106. 2-trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine Dihydrochloride

107. Trifluoperazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

108. Trifluoperazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

109. 10h-phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, Hydrochloride (1:2)

110. Trifluoperazine Dihydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-01
3 Chemical and Physical Properties
Molecular Weight 480.4 g/mol
Molecular Formula C21H26Cl2F3N3S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass479.1176589 g/mol
Monoisotopic Mass479.1176589 g/mol
Topological Polar Surface Area35 Ų
Heavy Atom Count30
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameTrifluoperazine hydrochloride
Drug LabelEach film-coated tablet, for oral administration, contains trifluoperazine hydrochloride, USP equivalent to 1 mg, 2 mg, 5 mg, or 10 mg trifluoperazine.The structural formula is:C21H24F3N3S2HCl M.W. 480.43C21H24F3N3S2...
Active IngredientTrifluoperazine hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
Market StatusPrescription
CompanySandoz; Mylan

2 of 2  
Drug NameTrifluoperazine hydrochloride
Drug LabelEach film-coated tablet, for oral administration, contains trifluoperazine hydrochloride, USP equivalent to 1 mg, 2 mg, 5 mg, or 10 mg trifluoperazine.The structural formula is:C21H24F3N3S2HCl M.W. 480.43C21H24F3N3S2...
Active IngredientTrifluoperazine hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 5mg base; eq 2mg base; eq 1mg base; eq 10mg base
Market StatusPrescription
CompanySandoz; Mylan

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Phenothiazines [CS]; Phenothiazine [EPC]

ABOUT THIS PAGE

Trifluoperazine Dihydrochloride Manufacturers

A Trifluoperazine Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trifluoperazine Dihydrochloride, including repackagers and relabelers. The FDA regulates Trifluoperazine Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trifluoperazine Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Trifluoperazine Dihydrochloride Suppliers

A Trifluoperazine Dihydrochloride supplier is an individual or a company that provides Trifluoperazine Dihydrochloride active pharmaceutical ingredient (API) or Trifluoperazine Dihydrochloride finished formulations upon request. The Trifluoperazine Dihydrochloride suppliers may include Trifluoperazine Dihydrochloride API manufacturers, exporters, distributors and traders.

Trifluoperazine Dihydrochloride GMP

Trifluoperazine Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trifluoperazine Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trifluoperazine Dihydrochloride GMP manufacturer or Trifluoperazine Dihydrochloride GMP API supplier for your needs.

Trifluoperazine Dihydrochloride CoA

A Trifluoperazine Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Trifluoperazine Dihydrochloride's compliance with Trifluoperazine Dihydrochloride specifications and serves as a tool for batch-level quality control.

Trifluoperazine Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Trifluoperazine Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trifluoperazine Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Trifluoperazine Dihydrochloride EP), Trifluoperazine Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trifluoperazine Dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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