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ACTIVE PHARMA INGREDIENTS

9 API Suppliers, 7 USDMF, 1 EU WC, 1 NDC API, 2 Listed Suppliers, $ API Reference Price

9 API Suppliers
7 USDMF
1 EU WC
1 NDC API
2 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

47 FDF Dossiers, 33 FDA Orange Book, 3 Canada, 11 Listed Dossiers

47 FDF Dossiers
33 FDA Orange Book
3 Canada
11 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 3 DKSH, 6 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 12 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 3 Actylis, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 23 BASF, 10 Corel Pharma Chem, 5 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 29 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 11 Microlex e.U, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 6 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 16 Roquette, 7 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

62 Fillers, Diluents & Binders, 46 Coating Systems & Additives, 30 Direct Compression, 28 Controlled & Modified Release, 22 Granulation, 20 Disintegrants & Superdisintegrants, 18 Thickeners and Stabilizers, 14 Co-Processed Excipients, 13 Lubricants & Glidants, 11 Solubilizers, 9 Film Formers & Plasticizers, 9 Taste Masking, 8 Topical, 6 Chewable & Orodispersible Aids, 5 Empty Capsules, 5 Parenteral, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Coloring Agents, 4 Emulsifying Agents, 3 Rheology Modifiers, 1 Surfactant & Foaming Agents

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices

MARKET PLACE

6 APIs

marketPlace
6 APIs

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 254

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

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Data Compilation #PharmaFlow

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GLOBAL SALES INFORMATION

US Medicaid (USD)

2,572,825

Annual Reports (USD Million)

Finished Drug Prices

203 RELATED EXCIPIENT COMPANIES

326EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Cpd000059133, Mls000069471, Fluoperazine, Calmazine, Smr000059133, Stalazine hydrochloride

Molecular Formula

C₂₁H₂₅ClF₃N₃S

Molecular Weight

444.0 g/mol

InChI Key

RIULCFSTKRDHBX-UHFFFAOYSA-N

A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.

1 2D Structure

Trifluoperazine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

2.1.2 InChI

InChI=1S/C21H24F3N3S.ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;/h2-3,5-8,15H,4,9-14H2,1H3;1H

2.1.3 InChI Key

RIULCFSTKRDHBX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Apo Trifluoperazine

2. Apo-trifluoperazine

3. Apotrifluoperazine

4. Flupazine

5. Stelazine

6. Terfluzine

7. Trifluoperazine

8. Trifluoperazine Hcl

9. Trifluoperazine Hydrochloride

10. Trifluoroperazine

11. Trifluperazine

12. Triftazin

2.2.2 Depositor-Supplied Synonyms

1. Cpd000059133

2. Mls000069471

3. Fluoperazine

4. Calmazine

5. Smr000059133

6. Stalazine Hydrochloride

7. 10h-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, Hydrochloride (1:2)

8. Stelazine Dihydrochloride

9. Trifluperazine Dihydrochloride

10. Mls001146870

11. Mls002702821

12. Trifluoroperazine Dihydrochloride

13. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

14. 10-[3-(4-methylpiperazinyl)propyl]-2-(trifluoromethyl)phenothiazine, Chloride, Chloride

15. Nsc17474

16. Skf 5019

17. Eskazine Dihydrochloride

18. Triflurin Dihydrochloride

19. Opera_id_1296

20. Trifluoperazine Hydrochoride

21. Chembl1710

22. Schembl41194

23. Tripfluoperazine Hydrochloride

24. Mls000758242

25. Mls001423986

26. Mls002222216

27. Triflorperazine Dihydrochloride

28. Trifluoropyrazin Dihydrochloride

29. Pharmakon1600-01500591

30. Nsc757369

31. Akos016395836

32. Ccg-100803

33. Nc00053

34. Ncgc00180883-01

35. Ncgc00180883-02

36. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D1 &gh 2

2.3 Create Date

2005-07-29

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₅ClF₃N₃S
Molecular Weight	444.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	443.1409812 g/mol
Monoisotopic Mass	443.1409812 g/mol
Topological Polar Surface Area	35 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

API SUPPLIERS

01

Sanofi

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Contact Supplier

France

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Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Portfolio PDF

Product Web Link

02

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Trifarma

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

04

GSK

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

05

ACIC Europe API & Pharmaceuticals

Cyprus

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

06

Cyclo Industries

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

07

Bridgechem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

08

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

09

Anphar Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

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USDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Fillers, Diluents & Binders

Coating Systems & Additives

Direct Compression

Controlled & Modified Release

Granulation

Disintegrants & Superdisintegrants

Thickeners and Stabilizers

Co-Processed Excipients

Lubricants & Glidants

Solubilizers

Film Formers & Plasticizers

Taste Masking

Topical

Chewable & Orodispersible Aids

Empty Capsules

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers

7 USDMF

1 EU WC

1 NDC API

2 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

47 FDF Dossiers

33 FDA Orange Book

3 Canada

11 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Seqens

3 DKSH

6 Faran Shimi Pharmaceutical

1 Boai NKY Pharmaceuticals Ltd

12 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 ACG Worldwide

3 Actylis

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

23 BASF

10 Corel Pharma Chem

5 DFE Pharma

1 Finar

7 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

29 Kerry

3 Kima Chemical

6 Lonza Capsugel

11 Microlex e.U

2 Nomisma Healthcare

2 Novo Excipients

2 Pharmatrans-Sanaq

6 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

16 Roquette

7 Seppic

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

2 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

62 Fillers, Diluents & Binders

46 Coating Systems & Additives

30 Direct Compression

28 Controlled & Modified Release

22 Granulation

20 Disintegrants & Superdisintegrants

18 Thickeners and Stabilizers

14 Co-Processed Excipients

13 Lubricants & Glidants

11 Solubilizers

9 Film Formers & Plasticizers

9 Taste Masking

8 Topical

6 Chewable & Orodispersible Aids

5 Empty Capsules

5 Parenteral

4 Vegetarian Capsules

4 API Stability Enhancers

4 Coloring Agents

4 Emulsifying Agents

3 Rheology Modifiers

1 Surfactant & Foaming Agents

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

4 Finished Drug Prices

MARKET PLACE

6 APIs