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    Chemistry

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    Also known as: Cpd000059133, Mls000069471, Fluoperazine, Calmazine, Smr000059133, Stalazine hydrochloride
    Molecular Formula
    C21H25ClF3N3S
    Molecular Weight
    444.0  g/mol
    InChI Key
    RIULCFSTKRDHBX-UHFFFAOYSA-N
    Trifluoperazine Hydrochloride
    A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
    1 2D Structure

    Trifluoperazine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H24F3N3S.ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;/h2-3,5-8,15H,4,9-14H2,1H3;1H
    2.1.3 InChI Key
    RIULCFSTKRDHBX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Apo Trifluoperazine

    2. Apo-trifluoperazine

    3. Apotrifluoperazine

    4. Flupazine

    5. Stelazine

    6. Terfluzine

    7. Trifluoperazine

    8. Trifluoperazine Hcl

    9. Trifluoperazine Hydrochloride

    10. Trifluoroperazine

    11. Trifluperazine

    12. Triftazin

    2.2.2 Depositor-Supplied Synonyms

    1. Cpd000059133

    2. Mls000069471

    3. Fluoperazine

    4. Calmazine

    5. Smr000059133

    6. Stalazine Hydrochloride

    7. 10h-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, Hydrochloride (1:2)

    8. Stelazine Dihydrochloride

    9. Trifluperazine Dihydrochloride

    10. Mls001146870

    11. Mls002702821

    12. Trifluoroperazine Dihydrochloride

    13. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

    14. 10-[3-(4-methylpiperazinyl)propyl]-2-(trifluoromethyl)phenothiazine, Chloride, Chloride

    15. Nsc17474

    16. Skf 5019

    17. Eskazine Dihydrochloride

    18. Triflurin Dihydrochloride

    19. Opera_id_1296

    20. Trifluoperazine Hydrochoride

    21. Chembl1710

    22. Schembl41194

    23. Tripfluoperazine Hydrochloride

    24. Mls000758242

    25. Mls001423986

    26. Mls002222216

    27. Triflorperazine Dihydrochloride

    28. Trifluoropyrazin Dihydrochloride

    29. Pharmakon1600-01500591

    30. Nsc757369

    31. Akos016395836

    32. Ccg-100803

    33. Nc00053

    34. Ncgc00180883-01

    35. Ncgc00180883-02

    36. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D1 &gh 2

    2.3 Create Date
    2005-07-29
    3 Chemical and Physical Properties
    Molecular Weight 444.0 g/mol
    Molecular Formula C21H25ClF3N3S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass443.1409812 g/mol
    Monoisotopic Mass443.1409812 g/mol
    Topological Polar Surface Area35 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity510
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    API Reference Price

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    ABOUT THIS PAGE

    Trifluoperazine Hydrochloride Manufacturers

    A Trifluoperazine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trifluoperazine Hydrochloride, including repackagers and relabelers. The FDA regulates Trifluoperazine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trifluoperazine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Trifluoperazine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Trifluoperazine Hydrochloride Suppliers

    A Trifluoperazine Hydrochloride supplier is an individual or a company that provides Trifluoperazine Hydrochloride active pharmaceutical ingredient (API) or Trifluoperazine Hydrochloride finished formulations upon request. The Trifluoperazine Hydrochloride suppliers may include Trifluoperazine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Trifluoperazine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Trifluoperazine Hydrochloride USDMF

    A Trifluoperazine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Trifluoperazine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Trifluoperazine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Trifluoperazine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Trifluoperazine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Trifluoperazine Hydrochloride USDMF includes data on Trifluoperazine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Trifluoperazine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Trifluoperazine Hydrochloride suppliers with USDMF on PharmaCompass.

    Trifluoperazine Hydrochloride WC

    A Trifluoperazine Hydrochloride written confirmation (Trifluoperazine Hydrochloride WC) is an official document issued by a regulatory agency to a Trifluoperazine Hydrochloride manufacturer, verifying that the manufacturing facility of a Trifluoperazine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Trifluoperazine Hydrochloride APIs or Trifluoperazine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Trifluoperazine Hydrochloride WC (written confirmation) as part of the regulatory process.

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    Trifluoperazine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Trifluoperazine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Trifluoperazine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Trifluoperazine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Trifluoperazine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Trifluoperazine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Trifluoperazine Hydrochloride suppliers with NDC on PharmaCompass.

    Trifluoperazine Hydrochloride GMP

    Trifluoperazine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Trifluoperazine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trifluoperazine Hydrochloride GMP manufacturer or Trifluoperazine Hydrochloride GMP API supplier for your needs.

    Trifluoperazine Hydrochloride CoA

    A Trifluoperazine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Trifluoperazine Hydrochloride's compliance with Trifluoperazine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Trifluoperazine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Trifluoperazine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Trifluoperazine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Trifluoperazine Hydrochloride EP), Trifluoperazine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trifluoperazine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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