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Chemistry

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Also known as: 1098-60-8, Triflupromazine hcl, Flumazin, Fluorofen, Neoprin, Siquil
Molecular Formula
C18H20ClF3N2S
Molecular Weight
388.9  g/mol
InChI Key
FTNWXGFYRHWUKG-UHFFFAOYSA-N
FDA UNII
9E75N4A5HM

Triflupromazine Hydrochloride
A phenothiazine used as an antipsychotic agent and as an antiemetic.
1 2D Structure

Triflupromazine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
2.1.3 InChI Key
FTNWXGFYRHWUKG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F.Cl
2.2 Other Identifiers
2.2.1 UNII
9E75N4A5HM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Fluopromazine

2. Siquil

3. Trifluopromazine

4. Triflupromazine

2.3.2 Depositor-Supplied Synonyms

1. 1098-60-8

2. Triflupromazine Hcl

3. Flumazin

4. Fluorofen

5. Neoprin

6. Siquil

7. Nivoman

8. Triflupromazine (hydrochloride)

9. Psyquil

10. Vesprin Hydrochloride

11. Triflupromazine Monohydrochloride

12. Trifluopromazine Hydrochloride

13. Fluopromazine Monohydrochloride

14. Mc 4703

15. Nsc-14959

16. Nsc-17473

17. Mls000069672

18. 9e75n4a5hm

19. 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine Monohydrochloride

20. 10h-phenothiazine-10-propanamine, N,n-dimethyl-2-(trifluoromethyl)-, Monohydrochloride

21. N,n-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride

22. Mc-4703

23. Ncgc00094410-02

24. Smr000058517

25. Vesprin (tn)

26. Dsstox_cid_25804

27. Dsstox_rid_81142

28. Dsstox_gsid_45804

29. 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)phenothiazine Hydrochloride

30. Chebi:9712

31. N,n-dimethyl-2-(trifluoromethyl)-10h-phenothiazine-10-propanamine, Monohydrochloride

32. Nsc14959

33. Nsc17473

34. Wln: T C666 Bn Isj B3n1&1 Exfff

35. N,n-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine Hydrochloride

36. Sr-01000000224

37. Triflupromazine Hydrochloride [jan]

38. Einecs 214-149-6

39. Trifluopromazine Hydrochloride (van)

40. Cas-1098-60-8

41. Nsc 14959

42. Nsc 17473

43. Unii-9e75n4a5hm

44. Sr-01000000224-4

45. 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine Hydrochloride

46. 10h-phenothiazine-10-propanamine,n-dimethyl-2-(trifluoromethyl)-, Monohydrochloride

47. N,n-dimethyl-3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propan-1-amine Hydrochloride

48. N,n-dimethyl-3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propan-1-amine Hydrochloride

49. Prestwick_893

50. Triflupromazine Hydrochloride [usp:jan]

51. Opera_id_486

52. Fluopromazine Hydrochloride

53. Mls001148408

54. Mls002222277

55. Schembl317144

56. Spectrum1503118

57. Regid_for_cid_66069

58. Chembl1201102

59. Dtxsid8045804

60. Hms1568k07

61. Hms1922g15

62. Pharmakon1600-01503118

63. Hy-b0909

64. Tox21_111276

65. Tox21_501146

66. Mfcd00058103

67. Nsc758387

68. S5565

69. Akos024288004

70. Tox21_111276_1

71. Ccg-213116

72. Lp01146

73. Nsc-758387

74. Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, Monohydrochloride

75. Ncgc00016012-12

76. Ncgc00094410-01

77. Ncgc00094410-03

78. Ncgc00094410-04

79. Ncgc00094410-05

80. Ncgc00261831-01

81. Triflupromazine Hydrochloride (jan/usp)

82. Bs-25525

83. Triflupromazine Hydrochloride [mi]

84. Eu-0101146

85. Ft-0736671

86. Sw197014-3

87. T3389

88. Triflupromazine Hydrochloride [mart.]

89. Triflupromazine Hydrochloride [vandf]

90. Triflupromazine Hydrochloride [usp-rs]

91. Triflupromazine Hydrochloride [who-dd]

92. C71345

93. D00800

94. T 2896

95. Triflupromazine Hydrochloride [green Book]

96. Triflupromazine Hydrochloride [orange Book]

97. J-002339

98. Sr-01000000224-2

99. Sr-01000000224-8

100. Triflupromazine Hydrochloride [usp Monograph]

101. Q27108479

102. Z1642388275

103. Triflupromazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

104. Triflupromazine Hydrochloride, Vetranal(tm), Analytical Standard

105. 10-[3-(dimethylamino)-1-propyl]-2-(trifluoromethyl)phenothiazine Hydrochloride

106. Dimethyl({3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl})amine Hydrochloride

107. N,n-dimethyl-2-(trifluoromethyl)-10h-phenothiazine-10-propanamine Hydrochloride (1:1)

108. Phenothiazine, 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)-, Hydrochloride

109. Triflupromazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 388.9 g/mol
Molecular Formula C18H20ClF3N2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass388.0987820 g/mol
Monoisotopic Mass388.0987820 g/mol
Topological Polar Surface Area31.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity416
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


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PharmaCompass offers a list of Triflupromazine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Triflupromazine Hydrochloride manufacturer or Triflupromazine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Triflupromazine Hydrochloride manufacturer or Triflupromazine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Triflupromazine Hydrochloride API Price utilized in the formulation of products. Triflupromazine Hydrochloride API Price is not always fixed or binding as the Triflupromazine Hydrochloride Price is obtained through a variety of data sources. The Triflupromazine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Triflupromazine Hydrochloride

Synonyms

1098-60-8, Triflupromazine hcl, Flumazin, Fluorofen, Neoprin, Siquil

Cas Number

1098-60-8

Unique Ingredient Identifier (UNII)

9E75N4A5HM

About Triflupromazine Hydrochloride

A phenothiazine used as an antipsychotic agent and as an antiemetic.

Triflupromazine Hydrochloride Manufacturers

A Triflupromazine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Triflupromazine Hydrochloride, including repackagers and relabelers. The FDA regulates Triflupromazine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Triflupromazine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Triflupromazine Hydrochloride Suppliers

A Triflupromazine Hydrochloride supplier is an individual or a company that provides Triflupromazine Hydrochloride active pharmaceutical ingredient (API) or Triflupromazine Hydrochloride finished formulations upon request. The Triflupromazine Hydrochloride suppliers may include Triflupromazine Hydrochloride API manufacturers, exporters, distributors and traders.

Triflupromazine Hydrochloride GMP

Triflupromazine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Triflupromazine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Triflupromazine Hydrochloride GMP manufacturer or Triflupromazine Hydrochloride GMP API supplier for your needs.

Triflupromazine Hydrochloride CoA

A Triflupromazine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Triflupromazine Hydrochloride's compliance with Triflupromazine Hydrochloride specifications and serves as a tool for batch-level quality control.

Triflupromazine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Triflupromazine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Triflupromazine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Triflupromazine Hydrochloride EP), Triflupromazine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Triflupromazine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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