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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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ACTIVE PHARMA INGREDIENTS

27 API Suppliers, 3 USDMF, 9 CEP/COS, 1 JDMF, 8 EU WC, 6 KDMF, 2 NDC API, 19 Listed Suppliers, $ API Reference Price

27 API Suppliers
3 USDMF
9 CEP/COS
1 JDMF
8 EU WC
6 KDMF
2 NDC API
19 Listed Suppliers
$ API Reference Price

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

29 FDF Dossiers, 7 Europe, 22 Listed Dossiers

29 FDF Dossiers
7 Europe
22 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 2 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices

globalSalesInformation
6 Finished Drug Prices

MARKET PLACE

10 APIs, 2 FDF Dossiers

marketPlace
10 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 3 Others

otherSolutions
2 EDQM
3 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: 13171-25-0, 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, Trimetazidine hydrochloride, Kyurinett, Trimetazidine hcl, Trimetazidine 2hcl

Molecular Formula

C₁₄H₂₄Cl₂N₂O₃

Molecular Weight

339.3 g/mol

InChI Key

VYFLPFGUVGMBEP-UHFFFAOYSA-N

FDA UNII

48V6723Z1P

A vasodilator used in angina of effort or ischemic heart disease.

1 2D Structure

Trimetazidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride

2.1.2 InChI

InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H

2.1.3 InChI Key

VYFLPFGUVGMBEP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

48V6723Z1P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Centrophne

2. Dihydrochloride, Trimetazidine

3. Idaptan

4. Trimtazidine Irex

5. Trimetazidine

6. Vasartel

7. Vastarel

2.3.2 Depositor-Supplied Synonyms

1. 13171-25-0

2. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride

3. Trimetazidine Hydrochloride

4. Kyurinett

5. Trimetazidine Hcl

6. Trimetazidine 2hcl

7. Trimetazidine (dihydrochloride)

8. Yoshimilon

9. Vastarel F

10. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihydrochloride

11. Trimetazidine Di-hcl

12. Trimetazidine Hydrochloride [jan]

13. Trimetazidine Dihcl

14. Trimethazidine Dihydrochloride

15. Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, Dihydrochloride

16. Mfcd00243086

17. 48v6723z1p

18. Nsc-759317

19. Trimetajust

20. Lubomail

21. Vastarel

22. Yosimilon

23. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride

24. Dsstox_cid_25407

25. Dsstox_rid_80858

26. Dsstox_gsid_45407

27. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride

28. Adexor

29. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride (9ci)

30. Sr-01000781912

31. Ncgc00016697-01

32. Einecs 236-117-0

33. Cas-13171-25-0

34. Unii-48v6723z1p

35. S 4004

36. Kyurinett (tn)

37. Prestwick_871

38. Schembl580378

39. Chembl3561076

40. Dtxsid1045407

41. Chebi:32262

42. Piperazine, 1-(2,3,4-trimethoxybenzyl)-, Dihydrochloride

43. Hms1569n19

44. Bcp21402

45. Hy-b0968

46. Trimetazidine For System Suitability

47. Trimetazidine Hydrochloride (jp17)

48. Tox21_110568

49. S4543

50. Akos015895369

51. Tox21_110568_1

52. Ab05480

53. Ac-5896

54. Ccg-213960

55. Cs-4453

56. Ks-1125

57. Nsc 759317

58. Ncgc00016697-04

59. Trimetazidine Dihydrochloride [mi]

60. Trimetazidine Hydrochloride [mart.]

61. Trimetazidine Hydrochloride [who-dd]

62. Ft-0630397

63. T2726

64. A25088

65. D01606

66. P10117

67. 2,3,4-trimethoxybenzylpiperazine Dihydrochloride

68. 171t250

69. Sr-01000781912-3

70. Sr-01000781912-4

71. Trimetazidine Dihydrochloride [ep Monograph]

72. W-108326

73. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihcl

74. Q27259190

75. F2173-1142

76. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride, 97%

77. Trimetazidine Dihydrochloride 1.0 Mg/ml In Methanol (as Free Base)

78. Trimetazidine For System Suitability, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₂₄Cl₂N₂O₃
Molecular Weight	339.3 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	338.1163980 g/mol
Monoisotopic Mass	338.1163980 g/mol
Topological Polar Surface Area	43 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	259
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

API SUPPLIERS

01

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

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India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

USV Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

USV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS

JDMF EU-WC

NDC

KDMF

VMF Others AUDIT

Portfolio PDF

05

Zeon Pharma Industries India Pvt L...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Zeon Pharma is a manufacturer and supplier of APIs & Intermediates.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

06

Cipla

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

07

Sichuan Xieli Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

08

Maps Laboratories Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

09

Fleming Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

10

Aragen Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

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USDMF

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API Reference Price

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CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715020200,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"1243","totalValueFC":"244263","currency":"EUR","unitRateINR":"113113","date":"07-May-2024","totalValueINR":"20360340","totalValueInUsd":"244263","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"3377266","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"90.00","actualQuantity":"90","unit":"KGS","unitRateFc":"1243","totalValueFC":"122789.1","currency":"EUR","unitRateINR":"114045.3","date":"06-Jul-2024","totalValueINR":"10264072.5","totalValueInUsd":"122789.1","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"4365876","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"1243","totalValueFC":"245578.2","currency":"EUR","unitRateINR":"114045.3","date":"06-Jul-2024","totalValueINR":"20528145","totalValueInUsd":"245578.2","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"4364240","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"1243","totalValueFC":"245578.2","currency":"EUR","unitRateINR":"114045.3","date":"06-Jul-2024","totalValueINR":"20528145","totalValueInUsd":"245578.2","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"4364386","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722882600,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SERVIER","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"1243","totalValueFC":"246070.3","currency":"EUR","unitRateINR":"114666.8","date":"06-Aug-2024","totalValueINR":"20640015","totalValueInUsd":"246070.3","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"4915487","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOTSURESNESCEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726511400,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"LES LABORATOIRES DU SAINT-LAURENT E.H. LTEE","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"90.00","actualQuantity":"90","unit":"KGS","unitRateFc":"1243","totalValueFC":"126486","currency":"EUR","unitRateINR":"117774.3","date":"17-Sep-2024","totalValueINR":"10599682.5","totalValueInUsd":"126486","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"5652187","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOT SURESNES CEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726511400,"product":"TRIMETAZIDINE DIHYDROCHLORIDE IP (BULK DRUG)","address":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"LES LABORATOIRES DU SAINT-LAURENT E.H. LTEE","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"SERVIER","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"1243","totalValueFC":"252972","currency":"EUR","unitRateINR":"117774.3","date":"17-Sep-2024","totalValueINR":"21199365","totalValueInUsd":"252972","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"5652139","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"50 RUE CARNOT SURESNES CEDEX FR","customerAddress":"SERDIA HOUSE ,OFF.DR.S.S.RAO ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

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FDF Dossiers

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Europe

01

World Medicine Ilac San ve tic LTD STl

Turkey

Antibody Engineering

Not Confirmed

02

STRODER Srl

Country

Antibody Engineering

Not Confirmed

03

Country

Antibody Engineering

Not Confirmed

04

Country

Antibody Engineering

Not Confirmed

05

Country

Antibody Engineering

Not Confirmed

06

Country

Antibody Engineering

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07

Country

Antibody Engineering

Not Confirmed

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Listed Dossiers

01

Cohance Lifesciences

India

Antibody Engineering

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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Digital Content

Regulatory Info :

Registration Country : India

Trimetazidine

Brand Name :

Dosage Form : Modified Release Table...

Dosage Strength : 35MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

02

Cohance Lifesciences

India

Antibody Engineering

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : India

Trimetazidine

Brand Name :

Dosage Form : Extended Release Pelle...

Dosage Strength : 41.38

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

03

AMN Life Science

India

Antibody Engineering

Not Confirmed

04

AMN Life Science

India

Antibody Engineering

Not Confirmed

05

Biofarm

Poland

Antibody Engineering

Not Confirmed

06

Medreich

India

Antibody Engineering

Not Confirmed

07

World Medicine

Turkey

Antibody Engineering

Not Confirmed

08

XL Laboratories Private Limited

India

Antibody Engineering

Not Confirmed

09

XL Laboratories Private Limited

India

Antibody Engineering

Not Confirmed

10

Zim Laboratories

India

Antibody Engineering

Not Confirmed

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DATA COMPILATION #PharmaFlow

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ABOUT THIS PAGE

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

27 API Suppliers

3 USDMF

9 CEP/COS

1 JDMF

8 EU WC

6 KDMF

2 NDC API

19 Listed Suppliers

$ API Reference Price

INTERMEDIATES

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

29 FDF Dossiers

7 Europe

22 Listed Dossiers

DIGITAL CONTENT

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6 Finished Drug Prices

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REF. STANDARDS & IMPURITIES

2 EDQM

3 Others

ANALYTICAL

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ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 136

MARKET PLACE

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

01

02

STRODER Srl

STRODER Srl

03

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