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    Chemistry

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    Also known as: 13171-25-0, 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, Trimetazidine hydrochloride, Kyurinett, Trimetazidine hcl, Trimetazidine 2hcl
    Molecular Formula
    C14H24Cl2N2O3
    Molecular Weight
    339.3  g/mol
    InChI Key
    VYFLPFGUVGMBEP-UHFFFAOYSA-N
    FDA UNII
    48V6723Z1P
    Trimetazidine
    A vasodilator used in angina of effort or ischemic heart disease.
    1 2D Structure

    Trimetazidine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
    2.1.2 InChI
    InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H
    2.1.3 InChI Key
    VYFLPFGUVGMBEP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    48V6723Z1P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Centrophne

    2. Dihydrochloride, Trimetazidine

    3. Idaptan

    4. Trimtazidine Irex

    5. Trimetazidine

    6. Vasartel

    7. Vastarel

    2.3.2 Depositor-Supplied Synonyms

    1. 13171-25-0

    2. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride

    3. Trimetazidine Hydrochloride

    4. Kyurinett

    5. Trimetazidine Hcl

    6. Trimetazidine 2hcl

    7. Trimetazidine (dihydrochloride)

    8. Yoshimilon

    9. Vastarel F

    10. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihydrochloride

    11. Trimetazidine Di-hcl

    12. Trimetazidine Hydrochloride [jan]

    13. Trimetazidine Dihcl

    14. Trimethazidine Dihydrochloride

    15. Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, Dihydrochloride

    16. Mfcd00243086

    17. 48v6723z1p

    18. Nsc-759317

    19. Trimetajust

    20. Lubomail

    21. Vastarel

    22. Yosimilon

    23. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride

    24. Dsstox_cid_25407

    25. Dsstox_rid_80858

    26. Dsstox_gsid_45407

    27. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride

    28. Adexor

    29. Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Dihydrochloride (9ci)

    30. Sr-01000781912

    31. Ncgc00016697-01

    32. Einecs 236-117-0

    33. Cas-13171-25-0

    34. Unii-48v6723z1p

    35. S 4004

    36. Kyurinett (tn)

    37. Prestwick_871

    38. Schembl580378

    39. Chembl3561076

    40. Dtxsid1045407

    41. Chebi:32262

    42. Piperazine, 1-(2,3,4-trimethoxybenzyl)-, Dihydrochloride

    43. Hms1569n19

    44. Bcp21402

    45. Hy-b0968

    46. Trimetazidine For System Suitability

    47. Trimetazidine Hydrochloride (jp17)

    48. Tox21_110568

    49. S4543

    50. Akos015895369

    51. Tox21_110568_1

    52. Ab05480

    53. Ac-5896

    54. Ccg-213960

    55. Cs-4453

    56. Ks-1125

    57. Nsc 759317

    58. Ncgc00016697-04

    59. Trimetazidine Dihydrochloride [mi]

    60. Trimetazidine Hydrochloride [mart.]

    61. Trimetazidine Hydrochloride [who-dd]

    62. Ft-0630397

    63. T2726

    64. A25088

    65. D01606

    66. P10117

    67. 2,3,4-trimethoxybenzylpiperazine Dihydrochloride

    68. 171t250

    69. Sr-01000781912-3

    70. Sr-01000781912-4

    71. Trimetazidine Dihydrochloride [ep Monograph]

    72. W-108326

    73. 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Dihcl

    74. Q27259190

    75. F2173-1142

    76. 1-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride, 97%

    77. Trimetazidine Dihydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    78. Trimetazidine For System Suitability, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 339.3 g/mol
    Molecular Formula C14H24Cl2N2O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass338.1163980 g/mol
    Monoisotopic Mass338.1163980 g/mol
    Topological Polar Surface Area43 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity259
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    API Reference Price

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    07-Jan-2021
    30-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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