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Chemistry

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Also known as: 56585-33-2, Bw 72u, Trimethoprim sulphate, E377mf8eq8, Trimethoprim sulfate [usan:usp], Bw-72u
Molecular Formula
C28H38N8O10S
Molecular Weight
678.7  g/mol
InChI Key
UILMMYFRNCCPLK-UHFFFAOYSA-N
FDA UNII
E377MF8EQ8

Trimethoprim Sulfate
Trimethoprim Sulfate is the sulfate salt form of trimethoprim, a synthetic substituted pyrimidine with antibacterial activity. Trimethoprim sulfate selectively binds to and reversibly inhibits dihydrofolate reductase, thereby blocking the production of tetrahydrofolic acid from dihydrofolic acid. This leads to an inhibition of bacterial synthesis of folic acid, thereby affecting nucleic acid and protein synthesis. Trimethoprim sulfate has a stronger binding affinity for the bacterial enzyme than for the corresponding mammalian enzyme.
1 2D Structure

Trimethoprim Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sulfuric acid;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
2.1.2 InChI
InChI=1S/2C14H18N4O3.H2O4S/c2*1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-5(2,3)4/h2*5-7H,4H2,1-3H3,(H4,15,16,17,18);(H2,1,2,3,4)
2.1.3 InChI Key
UILMMYFRNCCPLK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N.COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
E377MF8EQ8
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 56585-33-2

2. Bw 72u

3. Trimethoprim Sulphate

4. E377mf8eq8

5. Trimethoprim Sulfate [usan:usp]

6. Bw-72u

7. Trimethoprimsulfat

8. Sulfuric Acid;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

9. Unii-e377mf8eq8

10. Trimethoprim Sulfate [usan]

11. 2,4-pyrimidinediamine, 5-((3,4-trimethoxyphenyl)methyl)-, Sulfate (2:1)

12. Trimethoprim Sulfate (usp)

13. Chembl2110367

14. Dtxsid40205138

15. 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Sulfate (2:1)

16. Trimethoprim Sulfate [vandf]

17. Mfcd28386658

18. Trimethoprim Sulfate [mart.]

19. Trimethoprim Sulfate [who-dd]

20. Trimethoprim Sulfate [orange Book]

21. Trimethoprim Sulfate [usp Monograph]

22. Polytrim Component Trimethoprim Sulfate

23. D06236

24. Trimethoprim Sulfate Component Of Polytrim

25. Q27276814

26. 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Sulfate (2:1) (salt)

27. 2,4-pyrimidinediamine, 5-((3,4-trimethoxyphenyl)methyl)-, Sulfate (2:1) (salt)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 678.7 g/mol
Molecular Formula C28H38N8O10S
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count18
Rotatable Bond Count10
Exact Mass678.24316061 g/mol
Monoisotopic Mass678.24316061 g/mol
Topological Polar Surface Area294 Ų
Heavy Atom Count47
Formal Charge0
Complexity388
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

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ABOUT THIS PAGE

Trimethoprim Sulfate Manufacturers

A Trimethoprim Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trimethoprim Sulfate, including repackagers and relabelers. The FDA regulates Trimethoprim Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trimethoprim Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trimethoprim Sulfate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trimethoprim Sulfate Suppliers

A Trimethoprim Sulfate supplier is an individual or a company that provides Trimethoprim Sulfate active pharmaceutical ingredient (API) or Trimethoprim Sulfate finished formulations upon request. The Trimethoprim Sulfate suppliers may include Trimethoprim Sulfate API manufacturers, exporters, distributors and traders.

click here to find a list of Trimethoprim Sulfate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trimethoprim Sulfate GMP

Trimethoprim Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trimethoprim Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trimethoprim Sulfate GMP manufacturer or Trimethoprim Sulfate GMP API supplier for your needs.

Trimethoprim Sulfate CoA

A Trimethoprim Sulfate CoA (Certificate of Analysis) is a formal document that attests to Trimethoprim Sulfate's compliance with Trimethoprim Sulfate specifications and serves as a tool for batch-level quality control.

Trimethoprim Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Trimethoprim Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trimethoprim Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Trimethoprim Sulfate EP), Trimethoprim Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trimethoprim Sulfate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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