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1. 1,3,5-trimethylbenzene
2. 108-67-8
3. Sym-trimethylbenzene
4. Benzene, 1,3,5-trimethyl-
5. 3,5-dimethyltoluene
6. Fleet-x
7. Trimethylbenzol
8. S-trimethylbenzene
9. 2,4,6-trimethylbenzene
10. 1,3,5-trimethyl-benzene
11. Nsc 9273
12. Trimethylbenzene, 1,3,5-
13. Chebi:34833
14. 887l18kq6x
15. Nsc-9273
16. Dsstox_cid_6797
17. Dsstox_rid_78217
18. Dsstox_gsid_26797
19. Cas-108-67-8
20. Hsdb 92
21. Einecs 203-604-4
22. Un2325
23. Unii-887l18kq6x
24. Ai3-23973
25. Ccris 8147
26. Mesitylene, 98%
27. Mesitylene [mi]
28. Mesitylene [hsdb]
29. Mesitylene [inci]
30. Trimethylbenzol (related)
31. Trimethylbenzene (related)
32. 1,3, 5-trimethylbenzene
33. Ec 203-604-4
34. Bidd:er0286
35. Mesitylene (acd/name 4.0)
36. Mesitylene, Analytical Standard
37. Chembl1797281
38. Dtxsid6026797
39. Wln: 1r C1 E1
40. Mesitylene, Reagent Grade, 97%
41. Nsc9273
42. Benzene,1,3,5-trimethyl
43. Str03436
44. Zinc1699890
45. Tox21_201452
46. Tox21_300341
47. Mfcd00008538
48. Stl268905
49. 1,3,5-trimethylbenzene (mesitylene)
50. Akos000120144
51. Mesitylene, Purum, >=98.0% (gc)
52. Un 2325
53. Ncgc00247999-01
54. Ncgc00247999-02
55. Ncgc00254430-01
56. Ncgc00259003-01
57. Ft-0606520
58. S0658
59. T0470
60. A801911
61. Q425161
62. 1,3,5-trimethylbenzene 100 Microg/ml In Methanol
63. J-002179
64. J-521685
65. 1,3,5-trimethylbenzene [un2325] [flammable Liquid]
66. F0001-0175
67. Mesitylene, Certified Reference Material, Tracecert(r)
68. Z1262253023
| Molecular Weight | 120.19 g/mol |
|---|---|
| Molecular Formula | C9H12 |
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 120.093900383 g/mol |
| Monoisotopic Mass | 120.093900383 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 55 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The objective of this study was to determine the uptake and disposition of inhaled trimethylbenzenes (TMBs) in man. The toxicokinetics were studied in 10 male, healthy volunteers exposed to TMB vapor in an exposure chamber for 2 hr during a work load of 50 W. The subjects were exposed on four occasions to 25 ppm of 1,2,4-TMB, 1,2,3-TMB, and 1,3,5-TMB, and to 2 ppm of 1,2,4-TMB. The TMB isomers were analyzed in blood, urine, and exhaled air by gas chromatography. The relative respiratory uptake was in the range 56-64%. The elimination of TMBs was moderate compared to other aromatic solvents, with a total blood clearance of 0.6-1.0 L per hr per kg. Large volumes of distribution (30-39 liters/kg) and long terminal half-lives of the TMBs in blood (78-120 hr) imply extensive accumulation in adipose tissue. Exhalation during and postexposure accounted for 20-37% of the absorbed amount, whereas the urinary excretion of unchanged TMBs was low (< or = 0.002%). The kinetics of 1,2,4-TMB seemed linear up to 25 ppm. ...
PMID:8887444 Jarnberg J et al; Toxicol Appl Pharmacol 140 (2): 281-8 (1996)
Absorption takes place most readily by inhalation of the vapor, but the liquid can be absorbed from the gastro-intestinal tract, and probably, though slowly, by the intact skin.
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 112
... Only a small portion is excreted unchanged by the lungs, the greater part is oxidized to water-soluble metabolites, which are excreted by the urine, partly free, partly conjugated /as/ glycine and mesitylenic acid.
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 112
... Ten healthy male volunteers were exposed to trimethylbenzene (TMB) vapor in an exposure chamber for 2 hr at a work load of 50 W. The subjects were exposed on four occasions, to 25 ppm of 1,2,4-TMB, 1,2,3-TMB, and 1,3,5-TMB, respectively, and 2 ppm of 1,2,4-TMB. Urine was collected from the onset of exposure until the following morning. All six possible dimethylhippuric acid (DMHA) isomers were analyzed by high-performance liquid chromatography. About 22% of the inhaled amount of 1,2,4-TMB was excreted as DMHAs within 24 hr, mainly as 3,4-DMHA. The 24-hr recovery of 1,2,3-TMB as DMHAs was 11%. Only 3% of the absorbed amount of 1,3,5-TMB was excreted as 3,5,-DMHA. ... In addition to analysis of DMHAs, the excretion of unconjugated dimethylbenzoic acids in urine was estimated to account for approximately 3% of the dose of all TMBs. In conclusion, the urinary excretion of DMHA isomers may serve as a good indicator of TMB exposure. In this controlled short-term-exposure study the sum of excretion rate of several DMHA isomers reflected exposure more closely than did the excretion rate of any single DMHA.
PMID:9215938 Jarnberg J et al; Int Arch Occup Environ Health 69 (6): 491-7 (1997)
... Only a small portion is excreted unchanged by the lungs, the greater part is oxidized to water-soluble metabolites, which are excreted by the urine, partly free, partly conjugated /as/ glycine and mesitylenic acid.
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 112
Mesitylene yields 2,4,6-trimethylphenol in rat. /from table/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. M-5
Approximately 78% of oral dose of mesitylene was excreted as 3,5-dimethylhippuric acid; additional 7.6 and 8.2% were excreted as glucuronic and sulfuric acid conjugates.
PMID:1129786 Mikulski PI, Wiglusz R; Toxicol Appl Pharmacol 31 (1): 21-31 (1975)
Toxicity of Tri- and Tetramethylbenzenes: Material: 1,3,5-trimethylbenzene; Route of entry: oral (subacute); Species: rat; Dose or concentration: 1.2 g/kg/day; Results or Effects: Metabolites: 3,5-dimethylhippuric acid 78.0%, 3,5-dimethylbenzoic glucuronide 7.6%, and 3,5-dimethylbenzoic sulfate 1.2%. /From table/
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 4:271
The possibility of evaluating occupational exposure to mesitylene /depending/ on the determination of unchanged solvent in capillary blood or 3,5-dimethylbenzoic acid in urine was investigated. The volunteers were exposed to mesitylene in a toxicological chamber (range 10-150 mg/cu m). Concn of the solvent or its metabolite in biological material were determined by gas chromatography. The toxicokinetic data concerning retention in the lung, absorption and elimination of mesitylene and its metabolite in biological fluids were obtained. The highest correlation coefficient value was obtained for the relationship between the absorbed dose of mesitylene and the excretion rate of 3,5-dimethylbenzoic acid in urine (r= 0.95). ...
Kostrewski P, Wiaderna-Brycht A; Tox Lett 77 (1-3): 259-64 (1995)
... Ten healthy male volunteers were exposed to trimethylbenzene (TMB) vapor in an exposure chamber for 2 hr at a work load of 50 W. The subjects were exposed on four occasions, to 25 ppm of 1,2,4-TMB, 1,2,3-TMB, and 1,3,5-TMB, respectively, and 2 ppm of 1,2,4-TMB. Urine was collected from the onset of exposure until the following morning. All six possible dimethylhippuric acid (DMHA) isomers were analyzed by high-performance liquid chromatography. ... The half-times of the different DMHA isomers ranged from 4 to 16 hr.
PMID:9215938 Jarnberg J et al; Int Arch Occup Environ Health 69 (6): 491-7 (1997)
ABOUT THIS PAGE
A Trimethylbenzol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trimethylbenzol, including repackagers and relabelers. The FDA regulates Trimethylbenzol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trimethylbenzol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Trimethylbenzol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Trimethylbenzol supplier is an individual or a company that provides Trimethylbenzol active pharmaceutical ingredient (API) or Trimethylbenzol finished formulations upon request. The Trimethylbenzol suppliers may include Trimethylbenzol API manufacturers, exporters, distributors and traders.
click here to find a list of Trimethylbenzol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Trimethylbenzol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Trimethylbenzol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trimethylbenzol GMP manufacturer or Trimethylbenzol GMP API supplier for your needs.
A Trimethylbenzol CoA (Certificate of Analysis) is a formal document that attests to Trimethylbenzol's compliance with Trimethylbenzol specifications and serves as a tool for batch-level quality control.
Trimethylbenzol CoA mostly includes findings from lab analyses of a specific batch. For each Trimethylbenzol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Trimethylbenzol may be tested according to a variety of international standards, such as European Pharmacopoeia (Trimethylbenzol EP), Trimethylbenzol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trimethylbenzol USP).
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