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Chemistry

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Also known as: Trimethoquinol, Inolin, Trimetoquinol-hydrochloride, Aql 208, Trikvinol (triquinol) hydrochloride, (-)-trimetoquinol; aql 208; bentomex; inolin; nsc 288748
Molecular Formula
C19H24ClNO5
Molecular Weight
381.8  g/mol
InChI Key
UHSXRTHJCJGEKG-UHFFFAOYSA-N
FDA UNII
100GVI988J

Trimetoquinol
An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
1 2D Structure

Trimetoquinol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol;hydrochloride
2.1.2 InChI
InChI=1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H
2.1.3 InChI Key
UHSXRTHJCJGEKG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
100GVI988J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aq 110

2. Aq-110

3. Aq110

4. Aql 208

5. Aql-208

6. Aql208

7. Cv 705

8. Cv-705

9. Cv705

10. Tetroquinol

11. Tretoquinol

12. Tretoquinol Hydrochloride

13. Tretoquinol Hydrochloride Anhydrous

14. Tretoquinol Hydrochloride, (s)-isomer

15. Tretoquinol-(r)

16. Tretoquinol-(s) Hcl

17. Trimethoquinol

2.3.2 Depositor-Supplied Synonyms

1. Trimethoquinol

2. Inolin

3. Trimetoquinol-hydrochloride

4. Aql 208

5. Trikvinol (triquinol) Hydrochloride

6. (-)-trimetoquinol; Aql 208; Bentomex; Inolin; Nsc 288748

7. 100gvi988j

8. Nsc-288748

9. S-(-)-tretoquinol Hydrochloride

10. (-)-trimethoquinol

11. Chembl542101

12. Schembl1630263

13. (+/-)-tretoquinol Hydrochloride

14. Dtxsid00931229

15. Dl-trimetoquinol Hydrochloride

16. Nsc288748

17. 14187-92-9

18. (+/-)-trimetoquinol Hydrochloride

19. Tretoquinol Hydrochloride, (+/-)-

20. Tretoquinol Dl-form Hydrochloride [mi]

21. Tretoquinol Hydrochloride Anhydrous, (+/-)-

22. Q27251091

23. 6, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, Hydrochloride, (-)-

24. 1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol Hydrochloride

25. 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol;hydrochloride

26. 6, 1,2,3,4-tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-, Hydrochloride, (s)-

27. L-1-(3,5-trimethoxybenzl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline Hcl

28. 1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride

29. 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol--hydrogen Chloride (1/1)

30. 6,7-isoquinolinediol, 1,2,3,4-tetrahydro-1-((3,4,5-trimethoxyphenyl)methyl)-, Hydrochloride (1:1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 381.8 g/mol
Molecular Formula C19H24ClNO5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass381.1343006 g/mol
Monoisotopic Mass381.1343006 g/mol
Topological Polar Surface Area80.2 Ų
Heavy Atom Count26
Formal Charge0
Complexity409
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


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ABOUT THIS PAGE

Trimetoquinol Manufacturers

A Trimetoquinol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trimetoquinol, including repackagers and relabelers. The FDA regulates Trimetoquinol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trimetoquinol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trimetoquinol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trimetoquinol Suppliers

A Trimetoquinol supplier is an individual or a company that provides Trimetoquinol active pharmaceutical ingredient (API) or Trimetoquinol finished formulations upon request. The Trimetoquinol suppliers may include Trimetoquinol API manufacturers, exporters, distributors and traders.

click here to find a list of Trimetoquinol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trimetoquinol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Trimetoquinol Drug Master File in Japan (Trimetoquinol JDMF) empowers Trimetoquinol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Trimetoquinol JDMF during the approval evaluation for pharmaceutical products. At the time of Trimetoquinol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Trimetoquinol suppliers with JDMF on PharmaCompass.

Trimetoquinol GMP

Trimetoquinol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trimetoquinol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trimetoquinol GMP manufacturer or Trimetoquinol GMP API supplier for your needs.

Trimetoquinol CoA

A Trimetoquinol CoA (Certificate of Analysis) is a formal document that attests to Trimetoquinol's compliance with Trimetoquinol specifications and serves as a tool for batch-level quality control.

Trimetoquinol CoA mostly includes findings from lab analyses of a specific batch. For each Trimetoquinol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trimetoquinol may be tested according to a variety of international standards, such as European Pharmacopoeia (Trimetoquinol EP), Trimetoquinol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trimetoquinol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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