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Chemistry

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Also known as: 25332-13-2, Trimipramine mesilate, Y62g268p6x, 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-n,n,2-trimethylpropan-1-amine;methanesulfonic acid, Unii-y62g268p6x, Einecs 246-852-9
Molecular Formula
C21H30N2O3S
Molecular Weight
390.5  g/mol
InChI Key
KPPOZKAGJSXVND-UHFFFAOYSA-N
FDA UNII
Y62G268P6X

Trimipramine Mesylate
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
1 2D Structure

Trimipramine Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine;methanesulfonic acid
2.1.2 InChI
InChI=1S/C20H26N2.CH4O3S/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;1-5(2,3)4/h4-11,16H,12-15H2,1-3H3;1H3,(H,2,3,4)
2.1.3 InChI Key
KPPOZKAGJSXVND-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
Y62G268P6X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 10,11 Dihydro-n,n,beta-trimethyl-5h-dibenz(b,f)azepine-5-propanamine

2. Apo Trimip

3. Apo-trimip

4. Apotrimip

5. Beta, Trimipramin

6. Eldoral

7. Herphonal

8. Novo Tripramine

9. Novo-tripramine

10. Novotripramine

11. Nu Trimipramine

12. Nu-trimipramine

13. Nutrimipramine

14. Rhotrimine

15. Stangyl

16. Surmontil

17. Surmontil Maleate

18. Trimeprimine

19. Trimidura

20. Trimineurin

21. Trimineurin Maleate

22. Trimipramin Azu

23. Trimipramin Beta

24. Trimipramin Neurazpharm

25. Trimipramin Stada

26. Trimipramin-neurazpharm

27. Trimipramine

28. Trimipramine Maleate

29. Trimipramine Maleate (1:1)

30. Trimipramine Maleate (1:1), (+)-isomer

31. Trimipramine Maleate (1:1), (+-)-isomer

32. Trimipramine Maleate (1:1), (-)-isomer

33. Trimipramine Monohydrochloride

34. Trimipramine, (+-)-isomer

35. Trimipramine, (-)-isomer

36. Trimipraminneurazpharm

2.3.2 Depositor-Supplied Synonyms

1. 25332-13-2

2. Trimipramine Mesilate

3. Y62g268p6x

4. 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-n,n,2-trimethylpropan-1-amine;methanesulfonic Acid

5. Unii-y62g268p6x

6. Einecs 246-852-9

7. 10,11-dihydro-n,n,beta-trimethyl-5h-dibenz(b,f)azepine-5-propylamine Monomethanesulphonate

8. Schembl6511858

9. Dtxsid40948174

10. Trimipramine Mesilate [who-dd]

11. Trimipramine Mesylate/trimipramine Mesilate

12. Q27294300

13. 5h-dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-n,n,.beta.-trimethyl-, Methanesulfonate (1:1)

14. Methanesulfonic Acid--3-(10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n,n,2-trimethylpropan-1-amine (1/1)

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 390.5 g/mol
Molecular Formula C21H30N2O3S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass390.19771400 g/mol
Monoisotopic Mass390.19771400 g/mol
Topological Polar Surface Area69.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity409
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)


Adrenergic Uptake Inhibitors

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)


API Reference Price

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17-Aug-2021
03-Sep-2024
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ABOUT THIS PAGE

Trimipramine Mesylate Manufacturers

A Trimipramine Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trimipramine Mesylate, including repackagers and relabelers. The FDA regulates Trimipramine Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trimipramine Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trimipramine Mesylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trimipramine Mesylate Suppliers

A Trimipramine Mesylate supplier is an individual or a company that provides Trimipramine Mesylate active pharmaceutical ingredient (API) or Trimipramine Mesylate finished formulations upon request. The Trimipramine Mesylate suppliers may include Trimipramine Mesylate API manufacturers, exporters, distributors and traders.

click here to find a list of Trimipramine Mesylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trimipramine Mesylate WC

A Trimipramine Mesylate written confirmation (Trimipramine Mesylate WC) is an official document issued by a regulatory agency to a Trimipramine Mesylate manufacturer, verifying that the manufacturing facility of a Trimipramine Mesylate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Trimipramine Mesylate APIs or Trimipramine Mesylate finished pharmaceutical products to another nation, regulatory agencies frequently require a Trimipramine Mesylate WC (written confirmation) as part of the regulatory process.

click here to find a list of Trimipramine Mesylate suppliers with Written Confirmation (WC) on PharmaCompass.

Trimipramine Mesylate GMP

Trimipramine Mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trimipramine Mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trimipramine Mesylate GMP manufacturer or Trimipramine Mesylate GMP API supplier for your needs.

Trimipramine Mesylate CoA

A Trimipramine Mesylate CoA (Certificate of Analysis) is a formal document that attests to Trimipramine Mesylate's compliance with Trimipramine Mesylate specifications and serves as a tool for batch-level quality control.

Trimipramine Mesylate CoA mostly includes findings from lab analyses of a specific batch. For each Trimipramine Mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trimipramine Mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Trimipramine Mesylate EP), Trimipramine Mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trimipramine Mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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