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Tripamide

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ACTIVE PHARMA INGREDIENTS

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1 API Suppliers
1 JDMF

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Chemistry

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Also known as: Tripamide, 73803-48-2, N-[(1s,2r,6s,7r)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide, Normonal (tn), Schembl49666, Tripamide (jan/usan/inn)

Molecular Formula

C₁₆H₂₀ClN₃O₃S

Molecular Weight

369.9 g/mol

InChI Key

UHLOVGKIEARANS-QZHINBJYSA-N

1 2D Structure

Tripamide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(1S,2R,6S,7R)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide

2.1.2 InChI

InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12+,13-

2.1.3 InChI Key

UHLOVGKIEARANS-QZHINBJYSA-N

2.1.4 Canonical SMILES

C1CC2CC1C3C2CN(C3)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)N

2.1.5 Isomeric SMILES

C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2CN(C3)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. E 614

2. E614

3. N-(4-azo-endo-tricyclo(5.2.1.0.(2.6))-decan)-4-chloro-3-sulfamoylbenzamide

4. Tripamide

2.2.2 Depositor-Supplied Synonyms

1. Tripamide

2. 73803-48-2

3. N-[(1s,2r,6s,7r)-4-azatricyclo[5.2.1.02,6]decan-4-yl]-4-chloro-3-sulfamoylbenzamide

4. Normonal (tn)

5. Schembl49666

6. Tripamide (jan/usan/inn)

7. Chembl2104484

8. Zinc1481940

9. D01895

10. Q7843228

11. Benzamide, 3-(aminosulfonyl)-4-chloro-n-[(3ar,4r,7s,7as)-octahydro-4,7-methano-2h-isoindol-2-yl]-, Rel-

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₀ClN₃O₃S
Molecular Weight	369.9 g/mol
XLogP3	2.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	369.0913904 g/mol
Monoisotopic Mass	369.0913904 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	605
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Sodium Potassium Chloride Symporter Inhibitors

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. (See all compounds classified as Sodium Potassium Chloride Symporter Inhibitors.)

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