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Tripelennamine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 1 USDMF, 3 NDC API, 7 Listed Suppliers

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1 USDMF
3 NDC API
7 Listed Suppliers

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15 FDF Dossiers, 15 FDA Orange Book

15 FDF Dossiers
15 FDA Orange Book

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Synopsis

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Chemistry

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Also known as: 154-69-8, Tripelennamine hcl, Ahistamin, Dehistin, Piristin, Pyrinamine

Molecular Formula

C₁₆H₂₂ClN₃

Molecular Weight

291.82 g/mol

InChI Key

FSSICIQKZGUEAE-UHFFFAOYSA-N

FDA UNII

FWV8GJ56ZN

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

1 2D Structure

Tripelennamine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine;hydrochloride

2.1.2 InChI

InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

2.1.3 InChI Key

FSSICIQKZGUEAE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2.Cl

2.2 Other Identifiers

2.2.1 UNII

FWV8GJ56ZN

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Azaron

2. Histantin

3. Pyribenzamine

4. Tripelennamine

5. Tripelennamine Citrate

6. Tripelennamine Citrate (1:1)

7. Tripelennamine Maleate

8. Tripelennamine Maleate (1:1)

9. Tripelennamine Monohydrochloride

10. Vetibenzamin

2.3.2 Depositor-Supplied Synonyms

1. 154-69-8

2. Tripelennamine Hcl

3. Ahistamin

4. Dehistin

5. Piristin

6. Pyrinamine

7. Stanzamine

8. Tripelennamine (hydrochloride)

9. Pyribenzamine Hydrochloride

10. Antiallergicum Medivet

11. Dehistin Monohydrochloride

12. Pyribenzamine Monohydrochloride

13. Tripelennamine Monohydrochloride

14. Vetibenzamina

15. Pbz-sr

16. N1-benzyl-n2,n2-dimethyl-n1-(pyridin-2-yl)ethane-1,2-diamine Hydrochloride

17. Pyribenzamine Hcl

18. 22306-05-4

19. Fwv8gj56zn

20. Nsc-409943

21. 154-69-8 (hcl)

22. Smr000058623

23. Mls000069522

24. Mls001148406

25. 2-(benzyl(2-(dimethylamino)ethyl)amino)pyridine Monohydrochloride

26. N-benzyl-n',n'-dimethyl-n-2-pyridyl-ethylenediamine Hydrochloride

27. N,n-dimethyl-n'-(2-pyridyl)-n'-benzylethylenediamine Hydrochloride

28. Tripelennamine Hydrochloride [usp]

29. 1,2-ethanediamine, N,n-dimethyl-n'-(phenylmethyl)-n'-2-pyridinyl-, Hydrochloride

30. 1,2-ethanediamine, N,n-dimethyl-n'-(phenylmethyl)-n'-2-pyridinyl-, Monohydrochloride

31. 2-(benzyl(2-(dimethylamino)ethyl)amino)pyridine Hydrochloride

32. Recovr

33. N'-benzyl-n,n-dimethyl-n'-pyridin-2-ylethane-1,2-diamine;hydrochloride

34. Tri-tumine

35. Tripelennamine Hydrochloride (usp)

36. N-benzyl-n-[2-(dimethylamino)ethyl]pyridin-2-amine Hydrochloride

37. N,n-dimethyl-n-(phenylmethyl)-n-pyridin-2-ylethane-1,2-diamine Hydrochloride

38. Ccris 1969

39. Re-covr Injectable (veterinary)

40. Sr-01000003013

41. Einecs 205-833-5

42. Unii-fwv8gj56zn

43. Nih 10186

44. Nsc 409943

45. Pyrabenzamine

46. 2-[benzyl[2-(dimethylamino)ethyl]amino]pyridine Hydrochloride

47. Mfcd00012815

48. Tripelennamine Chloride

49. Cpd000058623

50. N-benzyl-n-dimethylaminoethyl Alpha-aminopyridine Hydrochloride

51. Opera_id_1597

52. Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-, Hydrochloride

53. Tripelennaminehydrochloride

54. Tripelenamine Hydrochloride

55. Ethylenediamine, N-benzyl-n',n'-dimethyl-n-(2-pyridyl)-, Hydrochloride

56. Tripelannamine Hydrochloride

57. N-benzyl-n-alpha-pyridyl-n',n'-dimethyl-aethylendiamin-hydrochlorid [german]

58. Pbz-sr (tn)

59. N(sup 1)-alpha-pyridyl-n(sup 1)-benzyl-n,n-dimethyl Ethylenediamine Monohydrochloride

60. Schembl98916

61. Mls000758254

62. Mls001423999

63. Chloropyramine Impurity 1 Hcl

64. Chembl1200446

65. Dtxsid6026248

66. Pyristine (pristina) Hydrochloride

67. N-benzyl-n-alpha-pyridyl-n',n'-dimethyl-aethylendiamin-hydrochlorid

68. Nsc409943

69. Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-, Monohydrochloride

70. S3146

71. Akos015913800

72. N'-benzyl-n,n-dimethyl-n'-pyridin-2-ylethane-1,2-diamine Hydrochloride

73. Ccg-100816

74. Cs-1395

75. Nc00066

76. 1,2-ethanediamine, N1,n1-dimethyl-n2-(phenylmethyl)-n2-2-pyridinyl-, Hydrochloride (1:?)

77. Tripelennamine Hydrochloride [mi]

78. As-59347

79. Hy-17428

80. Db-043233

81. Tripelennamine Hydrochloride [mart.]

82. Tripelennamine Hydrochloride [vandf]

83. Ft-0631854

84. Sw197446-3

85. Tripelennamine Hydrochloride [usp-rs]

86. Tripelennamine Hydrochloride [who-dd]

87. D02091

88. D70467

89. Wln: T6nj Bn1r & 2n1 & 1 & Gh

90. Tripelennamine Hydrochloride [green Book]

91. Tripelennamine Hydrochloride, Analytical Standard

92. A809564

93. Tripelennamine Hydrochloride [orange Book]

94. Sr-01000003013-6

95. Sr-01000003013-7

96. Tripelennamine Hydrochloride [usp Monograph]

97. W-108029

98. Q27278242

99. Z1552027600

100. Ethylenediamine,n'-dimethyl-n-(2-pyridyl)-, Hydrochloride

101. Tripelennamine Hydrochloride 100 Microg/ml In Acetonitrile

102. 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridine Hydrochloride

103. 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinhydrochloride

104. 2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride

105. 1, N,n-dimethyl-n'-(phenylmethyl)-n'-2-pyridinyl-, Monohydrochloride

106. N-[benzyl-n-(dimethylamino)ethyl] .alpha.-aminopyridine Hydrochloride

107. N-benzyl-n',n'-dimethyl-n-pyridin-2-ylethane-1,2-diamine Hydrochloride

108. N-benzyl-n-.alpha.-pyridyl-n',n'-dimethyl-aethylendiamin-hydrochlorid

109. 1,2-ethanediamine,n1,n1-dimethyl-n2-(phenylmethyl)-n2-2-pyridinyl-,hydrochloride

110. N(sup 1)-.alpha.-pyridyl-n(sup 1)-benzyl-n,n-dimethyl Ethylenediamine Monohydrochloride

111. N~1~-benzyl-n~2~,n~2~-dimethyl-n~1~-(2-pyridinyl)-1,2-ethanediamine Hydrochloride

112. Tripelennamine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

113. N'-benzyl-n,n-dimethyl-n'-(2-pyridyl)ethane-1,2-diamine Hydrochloride;tripelennamine Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₂ClN₃
Molecular Weight	291.82 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	291.1502254 g/mol
Monoisotopic Mass	291.1502254 g/mol
Topological Polar Surface Area	19.4 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	236
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

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