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    Also known as: 550-70-9, Actidilat, Venen, Actidil, Trans-triprolidine hydrochloride, Pro-actidil
    Molecular Formula
    C19H23ClN2
    Molecular Weight
    314.9  g/mol
    InChI Key
    WYUYEJNGHIOFOC-NWBUNABESA-N
    FDA UNII
    NG7A104R3J
    Triprolidine Hydrochloride
    Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
    1 2D Structure

    Triprolidine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
    2.1.3 InChI Key
    WYUYEJNGHIOFOC-NWBUNABESA-N
    2.1.4 Canonical SMILES
    CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.Cl
    2.1.5 Isomeric SMILES
    CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    NG7A104R3J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Actidil

    2. Anhydrous, Triprolidine Hydrochloride

    3. Hydrochloride Anhydrous, Triprolidine

    4. Hydrochloride, Triprolidine

    5. Pro Actidil

    6. Triprolidine

    7. Triprolidine Hydrochloride Anhydrous

    8. Triprolidine Monohydrochloride

    9. Triprolidine Monohydrochloride, (z)-isomer

    10. Triprolidine Monohydrochloride, Monohydrate

    11. Triprolidine Oxalate

    12. Triprolidine Oxalate, (trans)-isomer

    13. Triprolidine, (z)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 550-70-9

    2. Actidilat

    3. Venen

    4. Actidil

    5. Trans-triprolidine Hydrochloride

    6. Pro-actidil

    7. Pro-entra

    8. Triprolidine Hydrochloride Anhydrous

    9. 6138-79-0

    10. Entra

    11. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine Hydrochloride

    12. Triprolidine Hydrochloride (anhydrous)

    13. Mls000028751

    14. Ng7a104r3j

    15. Chebi:84119

    16. Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride, (e)-

    17. Smr000058521

    18. Triprolidine (hydrochloride)

    19. Triprolidine Hydrochloride (anh.)

    20. Sr-01000075292

    21. Einecs 208-985-0

    22. Unii-ng7a104r3j

    23. Pyridine, 2-((1e)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride

    24. Prestwick_575

    25. Mfcd00039044

    26. Opera_id_1214

    27. (e)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine Hydrochloride

    28. Trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

    29. Schembl42145

    30. Mls001148254

    31. Mls002207213

    32. Mls002222226

    33. Spectrum1500598

    34. Chembl1200450

    35. Hy-b1808a

    36. Dtxsid10872513

    37. Hms1568f06

    38. Hms1921i07

    39. Hms3411o04

    40. Hms3675o04

    41. Pharmakon1600-01500598

    42. Triprolidine Hydrochloride, >=99%

    43. Tox21_501130

    44. Ccg-40331

    45. Nsc757361

    46. Triprolidine Monohydrochloride (anh.)

    47. Akos015962154

    48. Lp01130

    49. Triprolidine Monohydrochloride Anhydrous

    50. Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, Monohydrochloride, (e)-

    51. Ncgc00094397-01

    52. Ncgc00094397-02

    53. Ncgc00094397-03

    54. Ncgc00261815-01

    55. Ac-15905

    56. As-13971

    57. Triprolidine Monohydrochloride (anhydrous)

    58. Anhydrous Triprolidine Hydrochloride

    59. Triprolidine Hydrochloride [who-dd]

    60. Cs-0013855

    61. Eu-0101130

    62. T 6764

    63. 138t790

    64. A868718

    65. A923663

    66. Anhydrous Triprolidine Hydrochloride [mart.]

    67. Sr-01000075292-1

    68. Sr-01000075292-3

    69. Sr-01000075292-7

    70. Triprolidine Hydrochloride, Sigma Reference Standard

    71. Q27157492

    72. (e)-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

    73. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridinehydrochloride

    74. (e)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine Hydrochloride

    75. 1-[(2e)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium Chloride

    76. 2-[(1e)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine Hydrochloride

    2.4 Create Date
    2006-03-07
    3 Chemical and Physical Properties
    Molecular Weight 314.9 g/mol
    Molecular Formula C19H23ClN2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count4
    Exact Mass314.1549764 g/mol
    Monoisotopic Mass314.1549764 g/mol
    Topological Polar Surface Area16.1 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity336
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

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ROAD","city":"CHENNAI, TAMIL NADU","supplier":"MALLADI DRUGS & PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"TUNIS","customer":"TO THE ORDER OF","customerCountry":"TUNISIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"475","totalValueFC":"23210.6","currency":"USD","unitRateINR":39174.07,"date":"14-Nov-2024","totalValueINR":"1958703.5","totalValueInUsd":"23210.6","indian_port":"Madras Air","hs_no":"29333990","bill_no":"5594447","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TUNISIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"NO.9, G.S.T. ROAD, CHENNAI, TAMIL NADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731868200,"product":"TRIPROLIDINE HYDROCHLORIDE BP","address":"NO.9, G.S.T. ROAD","city":"CHENNAI, TAMIL NADU","supplier":"MALLADI DRUGS & PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"490","totalValueFC":"4776","currency":"USD","unitRateINR":40304,"date":"18-Nov-2024","totalValueINR":"403040","totalValueInUsd":"4776","indian_port":"Madras Air","hs_no":"29333990","bill_no":"5686137","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"NO.9, G.S.T. ROAD, CHENNAI, TAMIL NADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732645800,"product":"TRIPROLIDINE HCL USP","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"DIVI'S LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"BEN GURION INTERNATIONAL APT, TA","customer":"TO THE ORDER OF","customerCountry":"ISRAEL","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"925","totalValueFC":"9163.6","currency":"USD","unitRateINR":77330,"date":"27-Nov-2024","totalValueINR":"773300","totalValueInUsd":"9163.6","indian_port":"Vizag-DLL SEZ","hs_no":"29333990","bill_no":"5942539","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ISRAEL","selfForZScoreResived":"Pharma Grade","supplierPort":"Vizag-DLL SEZ","supplierAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD, HYDERABAD,A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732732200,"product":"TRIPROLIDINE HYDROCHLORIDE BP","address":"NO.9, G.S.T. 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D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0001","unit":"KGS","unitRateFc":"17620000","totalValueFC":"1819","currency":"USD","unitRateINR":"1525785200","date":"01-Aug-2024","totalValueINR":"152578.52","totalValueInUsd":"1819","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"4826736","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD, US 21704, UNITED STATES OF AMERICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]
    12-Jan-2021
    28-Nov-2024
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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    ABOUT THIS PAGE

    Triprolidine Hydrochloride Manufacturers

    A Triprolidine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Triprolidine Hydrochloride, including repackagers and relabelers. The FDA regulates Triprolidine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Triprolidine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Triprolidine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Triprolidine Hydrochloride Suppliers

    A Triprolidine Hydrochloride supplier is an individual or a company that provides Triprolidine Hydrochloride active pharmaceutical ingredient (API) or Triprolidine Hydrochloride finished formulations upon request. The Triprolidine Hydrochloride suppliers may include Triprolidine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Triprolidine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Triprolidine Hydrochloride USDMF

    A Triprolidine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Triprolidine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Triprolidine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Triprolidine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Triprolidine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Triprolidine Hydrochloride USDMF includes data on Triprolidine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Triprolidine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Triprolidine Hydrochloride suppliers with USDMF on PharmaCompass.

    Triprolidine Hydrochloride WC

    A Triprolidine Hydrochloride written confirmation (Triprolidine Hydrochloride WC) is an official document issued by a regulatory agency to a Triprolidine Hydrochloride manufacturer, verifying that the manufacturing facility of a Triprolidine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Triprolidine Hydrochloride APIs or Triprolidine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Triprolidine Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Triprolidine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Triprolidine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Triprolidine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Triprolidine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Triprolidine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Triprolidine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Triprolidine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Triprolidine Hydrochloride suppliers with NDC on PharmaCompass.

    Triprolidine Hydrochloride GMP

    Triprolidine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Triprolidine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Triprolidine Hydrochloride GMP manufacturer or Triprolidine Hydrochloride GMP API supplier for your needs.

    Triprolidine Hydrochloride CoA

    A Triprolidine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Triprolidine Hydrochloride's compliance with Triprolidine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Triprolidine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Triprolidine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Triprolidine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Triprolidine Hydrochloride EP), Triprolidine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Triprolidine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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