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19 API Suppliers, 13 USDMF, 3 EU WC, 3 NDC API, 8 Listed Suppliers, $ API Reference Price

19 API Suppliers
13 USDMF
3 EU WC
3 NDC API
8 Listed Suppliers
$ API Reference Price

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3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

75 FDF Dossiers, 28 FDA Orange Book, 3 Canada, 29 South Africa, 15 Listed Dossiers

75 FDF Dossiers
28 FDA Orange Book
3 Canada
29 South Africa
15 Listed Dossiers

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 550-70-9, Actidilat, Venen, Actidil, Trans-triprolidine hydrochloride, Pro-actidil

Molecular Formula

C₁₉H₂₃ClN₂

Molecular Weight

314.9 g/mol

InChI Key

WYUYEJNGHIOFOC-NWBUNABESA-N

FDA UNII

NG7A104R3J

Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

1 2D Structure

Triprolidine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride

2.1.2 InChI

InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

2.1.3 InChI Key

WYUYEJNGHIOFOC-NWBUNABESA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.Cl

2.1.5 Isomeric SMILES

CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.Cl

2.2 Other Identifiers

2.2.1 UNII

NG7A104R3J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Actidil

2. Anhydrous, Triprolidine Hydrochloride

3. Hydrochloride Anhydrous, Triprolidine

4. Hydrochloride, Triprolidine

5. Pro Actidil

6. Triprolidine

7. Triprolidine Hydrochloride Anhydrous

8. Triprolidine Monohydrochloride

9. Triprolidine Monohydrochloride, (z)-isomer

10. Triprolidine Monohydrochloride, Monohydrate

11. Triprolidine Oxalate

12. Triprolidine Oxalate, (trans)-isomer

13. Triprolidine, (z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 550-70-9

2. Actidilat

3. Venen

4. Actidil

5. Trans-triprolidine Hydrochloride

6. Pro-actidil

7. Pro-entra

8. Triprolidine Hydrochloride Anhydrous

9. 6138-79-0

10. Entra

11. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine Hydrochloride

12. Triprolidine Hydrochloride (anhydrous)

13. Mls000028751

14. Ng7a104r3j

15. Chebi:84119

16. Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride, (e)-

17. Smr000058521

18. Triprolidine (hydrochloride)

19. Triprolidine Hydrochloride (anh.)

20. Sr-01000075292

21. Einecs 208-985-0

22. Unii-ng7a104r3j

23. Pyridine, 2-((1e)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride

24. Prestwick_575

25. Mfcd00039044

26. Opera_id_1214

27. (e)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine Hydrochloride

28. Trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

29. Schembl42145

30. Mls001148254

31. Mls002207213

32. Mls002222226

33. Spectrum1500598

34. Chembl1200450

35. Hy-b1808a

36. Dtxsid10872513

37. Hms1568f06

38. Hms1921i07

39. Hms3411o04

40. Hms3675o04

41. Pharmakon1600-01500598

42. Triprolidine Hydrochloride, >=99%

43. Tox21_501130

44. Ccg-40331

45. Nsc757361

46. Triprolidine Monohydrochloride (anh.)

47. Akos015962154

48. Lp01130

49. Triprolidine Monohydrochloride Anhydrous

50. Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, Monohydrochloride, (e)-

51. Ncgc00094397-01

52. Ncgc00094397-02

53. Ncgc00094397-03

54. Ncgc00261815-01

55. Ac-15905

56. As-13971

57. Triprolidine Monohydrochloride (anhydrous)

58. Anhydrous Triprolidine Hydrochloride

59. Triprolidine Hydrochloride [who-dd]

60. Cs-0013855

61. Eu-0101130

62. T 6764

63. 138t790

64. A868718

65. A923663

66. Anhydrous Triprolidine Hydrochloride [mart.]

67. Sr-01000075292-1

68. Sr-01000075292-3

69. Sr-01000075292-7

70. Triprolidine Hydrochloride, Sigma Reference Standard

71. Q27157492

72. (e)-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride

73. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridinehydrochloride

74. (e)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine Hydrochloride

75. 1-[(2e)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium Chloride

76. 2-[(1e)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine Hydrochloride

2.4 Create Date

2006-03-07

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₃ClN₂
Molecular Weight	314.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	314.1549764 g/mol
Monoisotopic Mass	314.1549764 g/mol
Topological Polar Surface Area	16.1 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	336
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

API SUPPLIERS

01

Sanofi

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

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Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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USDMF

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02

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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03

Malladi Drugs & Pharmaceuticals Li...

India

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04

Pharm-RX Chemical

U.S.A

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05

Hikal

India

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USDMF

01

Roussell Uclaf

France

Medlab Asia & Asia Health

Not Confirmed

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Digital Content

Triprolidine Hcl.

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 6178

Submission : 1986-01-23

Status : Inactive

Type : II

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02

Malladi Drugs And Pharmaceuticals Lt...

India

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Triprolidine Hydrochloride

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 17902

Submission : 2004-10-14

Status : Active

Type : II

03

Antibioticos Spa

Italy

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EU WC

01

Malladi Drugs & Pharmaceuticals Limited

India

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Triprolidine Hydrochloride(USP,BP, IP)

Date of Issue : 2022-06-08

Valid Till : 2025-07-14

Written Confirmation Number : WC-0093

Address of the Firm : Unit-3, 7B & 7C, SICOT Industrial Complex, Ranipet 632 403, Ranipet District, Ta...

02

Divis Laboratories

India

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03

Hikal

India

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API Reference Price

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