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Chemistry

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Also known as: 853400-76-7, Nnz-2566, Trofinetide [inn], Trofinetide [usan], Z2me8f52ql, L-glutamic acid, glycyl-2-methyl-l-prolyl-
Molecular Formula
C13H21N3O6
Molecular Weight
315.32  g/mol
InChI Key
BUSXWGRAOZQTEY-SDBXPKJASA-N
FDA UNII
Z2ME8F52QL

Trofinetide
Trofinetide (NNZ-2566), a neuroprotective analogue of [glypromate], is a novel molecule that has a profile suitable for both intravenous infusion and chronic oral delivery. It is currently in development to treat traumatic brain injury.
1 2D Structure

Trofinetide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
2.1.2 InChI
InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
2.1.3 InChI Key
BUSXWGRAOZQTEY-SDBXPKJASA-N
2.1.4 Canonical SMILES
CC1(CCCN1C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
Z2ME8F52QL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Glycyl-l-2-methylprolyl-l-glutamic Acid

2.3.2 Depositor-Supplied Synonyms

1. 853400-76-7

2. Nnz-2566

3. Trofinetide [inn]

4. Trofinetide [usan]

5. Z2me8f52ql

6. L-glutamic Acid, Glycyl-2-methyl-l-prolyl-

7. Acp-2566

8. ((s)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-l-glutamic Acid

9. Unii-z2me8f52ql

10. Nnz 2566

11. Glycyl-l-2-methylprolyl-l-glutamic Acid

12. Glycyl-2-methyl-l-prolyl-l-glutamic Acid

13. Trofinetide(nnz2566)

14. Trofinetide [who-dd]

15. Chembl197084

16. Schembl1170014

17. Gly-2-methyl-l-pro-l-glu-oh

18. Dtxsid101336041

19. Who 10076

20. Cs-8154

21. Db06045

22. Hy-16757

23. A16972

24. Q27294917

25. (2s)-2-[[(2s)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic Acid

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 315.32 g/mol
Molecular Formula C13H21N3O6
XLogP3-3.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass315.14303540 g/mol
Monoisotopic Mass315.14303540 g/mol
Topological Polar Surface Area150 Ų
Heavy Atom Count22
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in traumatic brain injuries.


5 Pharmacology and Biochemistry
5.1 Pharmacology

NNZ-2566 is shown to have multi-faceted action to significantly reduce both inflammation and apoptosis (cell death), protecting the neurons and their surrounding infrastructure.


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ABOUT THIS PAGE

Trofinetide Manufacturers

A Trofinetide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trofinetide, including repackagers and relabelers. The FDA regulates Trofinetide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trofinetide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Trofinetide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Trofinetide Suppliers

A Trofinetide supplier is an individual or a company that provides Trofinetide active pharmaceutical ingredient (API) or Trofinetide finished formulations upon request. The Trofinetide suppliers may include Trofinetide API manufacturers, exporters, distributors and traders.

click here to find a list of Trofinetide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Trofinetide NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Trofinetide as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Trofinetide API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Trofinetide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Trofinetide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Trofinetide NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Trofinetide suppliers with NDC on PharmaCompass.

Trofinetide GMP

Trofinetide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trofinetide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trofinetide GMP manufacturer or Trofinetide GMP API supplier for your needs.

Trofinetide CoA

A Trofinetide CoA (Certificate of Analysis) is a formal document that attests to Trofinetide's compliance with Trofinetide specifications and serves as a tool for batch-level quality control.

Trofinetide CoA mostly includes findings from lab analyses of a specific batch. For each Trofinetide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trofinetide may be tested according to a variety of international standards, such as European Pharmacopoeia (Trofinetide EP), Trofinetide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trofinetide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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