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Chemistry

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Also known as: 53783-83-8, Tromantadine [inn:dcf], N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide, H191jfg8wa, N-1-adamantyl-2-(2-(dimethylamino)ethoxy)acetamide, Tromantadine (inn)
Molecular Formula
C16H28N2O2
Molecular Weight
280.41  g/mol
InChI Key
UXQDWARBDDDTKG-UHFFFAOYSA-N
FDA UNII
H191JFG8WA

Tromantadine
Tromantadine is a cyclic amine with activity against herpes simplex virus. Tromantadine inhibits absorption of virions to cell surfaces, as well as penetration and uncoating of the virus.
1 2D Structure

Tromantadine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
2.1.2 InChI
InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)
2.1.3 InChI Key
UXQDWARBDDDTKG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCOCC(=O)NC12CC3CC(C1)CC(C3)C2
2.2 Other Identifiers
2.2.1 UNII
H191JFG8WA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.1(3,7))dec-1-ylacetamide

2. D 41

3. N-(1-adamantyl)-2-(2-dimethylaminoethoxy)acetamide

4. Tromantadin

5. Tromantadine Hydrochloride

6. Tromantadine Monohydrochloride

7. Tromantadine Monohydrochloride, Monohydrate

8. Tromantidine

9. Viru-merz

10. Viru-merz Serol

11. Viru-serol

2.3.2 Depositor-Supplied Synonyms

1. 53783-83-8

2. Tromantadine [inn:dcf]

3. N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide

4. H191jfg8wa

5. N-1-adamantyl-2-(2-(dimethylamino)ethoxy)acetamide

6. Tromantadine (inn)

7. Tromantadine [inn]

8. Tromantadinum [latin]

9. Tromantadin

10. Tromantadina

11. Tromantadinum

12. Tromantadinum [inn-latin]

13. Tromantadina [inn-spanish]

14. N-1-adamantyl-2-[2-(dimethylamino)ethoxy]acetamide

15. Einecs 258-770-0

16. Unii-h191jfg8wa

17. N-1-adamantyl-2-((2-dimethylamino)ethoxy)acetamide

18. Tromantadine [ii]

19. Tromantadine [mi]

20. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.13,7)dec-1-ylacetamide

21. N-(tricyclo(3.3.1.1(3,7))decyl)-2-(2-dimethylaminoethoxy)acetamid

22. Acetamide, 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.13,7)dec-1-yl-

23. Schembl148486

24. Tromantadine [who-dd]

25. N-(1-adamantyl)-2-(2-dimethylaminoethyloxy)acetamide

26. Chembl3085149

27. Chembl3989506

28. Dtxsid00202062

29. Chebi:135163

30. Zinc4214578

31. Hy-u00124

32. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.1(3,7))dec-1-ylacetamide

33. Cs-7161

34. Db13288

35. D07199

36. Q4463719

37. N-(adamantan-1-yl)-2-(2-(dimethylamino)ethoxy)acetamide

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 280.41 g/mol
Molecular Formula C16H28N2O2
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass280.215078140 g/mol
Monoisotopic Mass280.215078140 g/mol
Topological Polar Surface Area41.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)


4.2 ATC Code

D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06B - Chemotherapeutics for topical use

D06BB - Antivirals

D06BB02 - Tromantadine


J - Antiinfectives for systemic use

J05 - Antivirals for systemic use

J05A - Direct acting antivirals

J05AC - Cyclic amines

J05AC03 - Tromantadine


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ABOUT THIS PAGE

Looking for 53783-83-8 / Tromantadine API manufacturers, exporters & distributors?

Tromantadine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tromantadine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tromantadine manufacturer or Tromantadine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tromantadine manufacturer or Tromantadine supplier.

PharmaCompass also assists you with knowing the Tromantadine API Price utilized in the formulation of products. Tromantadine API Price is not always fixed or binding as the Tromantadine Price is obtained through a variety of data sources. The Tromantadine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tromantadine

Synonyms

53783-83-8, Tromantadine [inn:dcf], N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide, H191jfg8wa, N-1-adamantyl-2-(2-(dimethylamino)ethoxy)acetamide, Tromantadine (inn)

Cas Number

53783-83-8

Unique Ingredient Identifier (UNII)

H191JFG8WA

About Tromantadine

Tromantadine is a cyclic amine with activity against herpes simplex virus. Tromantadine inhibits absorption of virions to cell surfaces, as well as penetration and uncoating of the virus.

Tromantadine Manufacturers

A Tromantadine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tromantadine, including repackagers and relabelers. The FDA regulates Tromantadine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tromantadine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tromantadine Suppliers

A Tromantadine supplier is an individual or a company that provides Tromantadine active pharmaceutical ingredient (API) or Tromantadine finished formulations upon request. The Tromantadine suppliers may include Tromantadine API manufacturers, exporters, distributors and traders.

Tromantadine GMP

Tromantadine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tromantadine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tromantadine GMP manufacturer or Tromantadine GMP API supplier for your needs.

Tromantadine CoA

A Tromantadine CoA (Certificate of Analysis) is a formal document that attests to Tromantadine's compliance with Tromantadine specifications and serves as a tool for batch-level quality control.

Tromantadine CoA mostly includes findings from lab analyses of a specific batch. For each Tromantadine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tromantadine may be tested according to a variety of international standards, such as European Pharmacopoeia (Tromantadine EP), Tromantadine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tromantadine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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