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    Tromantadine

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    PharmaCompass
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    2D Structure
    Also known as: 53783-83-8, Tromantadine [inn:dcf], N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide, H191jfg8wa, N-1-adamantyl-2-(2-(dimethylamino)ethoxy)acetamide, Tromantadine (inn)
    Molecular Formula
    C16H28N2O2
    Molecular Weight
    280.41  g/mol
    InChI Key
    UXQDWARBDDDTKG-UHFFFAOYSA-N
    FDA UNII
    H191JFG8WA
    Tromantadine is a cyclic amine with activity against herpes simplex virus. Tromantadine inhibits absorption of virions to cell surfaces, as well as penetration and uncoating of the virus.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
    2.1.2 InChI
    InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)
    2.1.3 InChI Key
    UXQDWARBDDDTKG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCOCC(=O)NC12CC3CC(C1)CC(C3)C2
    2.2 Other Identifiers
    2.2.1 UNII
    H191JFG8WA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.1(3,7))dec-1-ylacetamide

    2. D 41

    3. N-(1-adamantyl)-2-(2-dimethylaminoethoxy)acetamide

    4. Tromantadin

    5. Tromantadine Hydrochloride

    6. Tromantadine Monohydrochloride

    7. Tromantadine Monohydrochloride, Monohydrate

    8. Tromantidine

    9. Viru-merz

    10. Viru-merz Serol

    11. Viru-serol

    2.3.2 Depositor-Supplied Synonyms

    1. 53783-83-8

    2. Tromantadine [inn:dcf]

    3. N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide

    4. H191jfg8wa

    5. N-1-adamantyl-2-(2-(dimethylamino)ethoxy)acetamide

    6. Tromantadine (inn)

    7. Tromantadine [inn]

    8. Tromantadinum [latin]

    9. Tromantadin

    10. Tromantadina

    11. Tromantadinum

    12. Tromantadinum [inn-latin]

    13. Tromantadina [inn-spanish]

    14. N-1-adamantyl-2-[2-(dimethylamino)ethoxy]acetamide

    15. Einecs 258-770-0

    16. Unii-h191jfg8wa

    17. N-1-adamantyl-2-((2-dimethylamino)ethoxy)acetamide

    18. Tromantadine [ii]

    19. Tromantadine [mi]

    20. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.13,7)dec-1-ylacetamide

    21. N-(tricyclo(3.3.1.1(3,7))decyl)-2-(2-dimethylaminoethoxy)acetamid

    22. Acetamide, 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.13,7)dec-1-yl-

    23. Schembl148486

    24. Tromantadine [who-dd]

    25. N-(1-adamantyl)-2-(2-dimethylaminoethyloxy)acetamide

    26. Chembl3085149

    27. Chembl3989506

    28. Dtxsid00202062

    29. Chebi:135163

    30. Zinc4214578

    31. Hy-u00124

    32. 2-(2-(dimethylamino)ethoxy)-n-tricyclo(3.3.1.1(3,7))dec-1-ylacetamide

    33. Cs-7161

    34. Db13288

    35. D07199

    36. Q4463719

    37. N-(adamantan-1-yl)-2-(2-(dimethylamino)ethoxy)acetamide

    2.4 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 280.41 g/mol
    Molecular Formula C16H28N2O2
    XLogP32.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count6
    Exact Mass280.215078140 g/mol
    Monoisotopic Mass280.215078140 g/mol
    Topological Polar Surface Area41.6 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity326
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    4.2 ATC Code

    D - Dermatologicals

    D06 - Antibiotics and chemotherapeutics for dermatological use

    D06B - Chemotherapeutics for topical use

    D06BB - Antivirals

    D06BB02 - Tromantadine

    J - Antiinfectives for systemic use

    J05 - Antivirals for systemic use

    J05A - Direct acting antivirals

    J05AC - Cyclic amines

    J05AC03 - Tromantadine