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Chemistry

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Also known as: Trigriluzole, Bhv-4157a, Troriluzole [usan], 1926203-09-9, Bhv-4157, S7h48s6k7h
Molecular Formula
C15H16F3N5O4S
Molecular Weight
419.4  g/mol
InChI Key
YBZSGIWIPOUSHY-UHFFFAOYSA-N
FDA UNII
S7H48S6K7H

Troriluzole
Troriluzole is a formulation comprised of a prodrug form of the benzothiazole derivative riluzole, with potential anti-depressant, anxiolytic and antineoplastic activities. Following oral administration, troriluzole is converted into the active form riluzole. While the mechanism of action of riluzole is unknown, its pharmacological activities, some of which may be related to its effect, include the following: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. These activities may result in myorelaxation and sedation due to the blockade of glutamatergic neurotransmission. Additionally, these activities may result in the inhibition of enzymes that are necessary for cell growth, which may decrease tumor cell growth and metastasis.
1 2D Structure

Troriluzole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-amino-N-[2-[methyl-[2-oxo-2-[[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amino]ethyl]amino]-2-oxoethyl]acetamide
2.1.2 InChI
InChI=1S/C15H16F3N5O4S/c1-23(13(26)6-20-11(24)5-19)7-12(25)22-14-21-9-3-2-8(4-10(9)28-14)27-15(16,17)18/h2-4H,5-7,19H2,1H3,(H,20,24)(H,21,22,25)
2.1.3 InChI Key
YBZSGIWIPOUSHY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(CC(=O)NC1=NC2=C(S1)C=C(C=C2)OC(F)(F)F)C(=O)CNC(=O)CN
2.2 Other Identifiers
2.2.1 UNII
S7H48S6K7H
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Trigriluzole

2. Bhv-4157a

3. Troriluzole [usan]

4. 1926203-09-9

5. Bhv-4157

6. S7h48s6k7h

7. Troriluzole (usan)

8. Glycinamide, Glycylglycyl-n2-methyl-n-(6-(trifluoromethoxy)-2-benzothiazolyl)-

9. Troriluzol

10. Troriluzole [inn]

11. Unii-s7h48s6k7h

12. Bhv4157a

13. Troriluzole [who-dd]

14. Chembl4297586

15. Schembl18154275

16. Gtpl11375

17. Bhv4157

18. Db15079

19. Fc-4157

20. Sb19816

21. Hy-122487

22. Cs-0085735

23. D11414

24. Q56407722

25. Glycylglycyl-n2-methyl-n-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)glycinamide

26. 2-(2-aminoacetamido)-n-methyl-n-(2-oxo-2-((6-(trifluoromethoxy)benzo[d]thiazol-2-yl)amino)ethyl)acetamide

2.4 Create Date
2016-08-16
3 Chemical and Physical Properties
Molecular Weight 419.4 g/mol
Molecular Formula C15H16F3N5O4S
XLogP31
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass419.08750967 g/mol
Monoisotopic Mass419.08750967 g/mol
Topological Polar Surface Area155 Ų
Heavy Atom Count28
Formal Charge0
Complexity595
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Troriluzole Manufacturers

A Troriluzole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Troriluzole, including repackagers and relabelers. The FDA regulates Troriluzole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Troriluzole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Troriluzole manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Troriluzole Suppliers

A Troriluzole supplier is an individual or a company that provides Troriluzole active pharmaceutical ingredient (API) or Troriluzole finished formulations upon request. The Troriluzole suppliers may include Troriluzole API manufacturers, exporters, distributors and traders.

click here to find a list of Troriluzole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Troriluzole GMP

Troriluzole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Troriluzole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Troriluzole GMP manufacturer or Troriluzole GMP API supplier for your needs.

Troriluzole CoA

A Troriluzole CoA (Certificate of Analysis) is a formal document that attests to Troriluzole's compliance with Troriluzole specifications and serves as a tool for batch-level quality control.

Troriluzole CoA mostly includes findings from lab analyses of a specific batch. For each Troriluzole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Troriluzole may be tested according to a variety of international standards, such as European Pharmacopoeia (Troriluzole EP), Troriluzole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Troriluzole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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