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Trospium Chloride

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ACTIVE PHARMA INGREDIENTS

27 API Suppliers, 15 USDMF, 10 CEP/COS, 5 EU WC, 7 NDC API, 14 Listed Suppliers, $ API Reference Price

27 API Suppliers
15 USDMF
10 CEP/COS
5 EU WC
7 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

18 Drugs in Development

18 Drugs in Development

FINISHED DOSAGE FORMULATIONS

28 FDF Dossiers, 14 FDA Orange Book, 6 Europe, 3 Canada, 5 Listed Dossiers

28 FDF Dossiers
14 FDA Orange Book
6 Europe
3 Canada
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Evonik, 2 Rochem International Inc, 7 SPI Pharma, 2 Seqens, 9 DKSH, 1 Pharm-RX Chemical, 7 Faran Shimi Pharmaceutical, 3 Boai NKY Pharmaceuticals Ltd, 13 Gangwal Healthcare, 8 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 9 Actylis, 3 Aeon Procare, 2 Alcedo Pharmachem, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 32 BASF, 1 Bioplus Life Sciences, 2 Clariant, 13 Corel Pharma Chem, 5 DFE Pharma, 2 Finar, 12 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 11 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 31 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 14 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 4 Novo Excipients, 2 Pharmatrans-Sanaq, 7 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 18 Roquette, 14 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 11 Sigachi Industries, 2 The Dow Chemical Company, 2 Valens Pharmachem, 3 Vasa Pharmachem, 1 Vertellus, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Evonik
2 Rochem International Inc
7 SPI Pharma
2 Seqens
9 DKSH
1 Pharm-RX Chemical
7 Faran Shimi Pharmaceutical
3 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
8 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
9 Actylis
3 Aeon Procare
2 Alcedo Pharmachem
7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
32 BASF
1 Bioplus Life Sciences
2 Clariant
13 Corel Pharma Chem
5 DFE Pharma
2 Finar
12 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
11 Ideal Cures Pvt Ltd
3 Ingredion Pharma Solutions
31 Kerry
3 Kima Chemical
6 Lonza Capsugel
14 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
4 Novo Excipients
2 Pharmatrans-Sanaq
7 Pluviaendo
3 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
18 Roquette
14 Seppic
5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
11 Sigachi Industries
2 The Dow Chemical Company
2 Valens Pharmachem
3 Vasa Pharmachem
1 Vertellus
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

83 Fillers, Diluents & Binders, 72 Coating Systems & Additives, 43 Controlled & Modified Release, 39 Direct Compression, 31 Thickeners and Stabilizers, 30 Solubilizers, 25 Granulation, 24 Film Formers & Plasticizers, 22 Topical, 22 Lubricants & Glidants, 21 Disintegrants & Superdisintegrants, 19 Taste Masking, 19 Parenteral, 15 Co-Processed Excipients, 9 Empty Capsules, 9 Emulsifying Agents, 9 Chewable & Orodispersible Aids, 6 Surfactant & Foaming Agents, 6 API Stability Enhancers, 5 Coloring Agents, 5 Rheology Modifiers, 4 Vegetarian Capsules

DIGITAL CONTENT

17 NEWS #PharmaBuzz

media
17 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 8 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
8 Finished Drug Prices

MARKET PLACE

2 APIs, 1 FDF Dossiers

marketPlace
2 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 Health Canada Patents

patents
1 Health Canada Patents

REF. STANDARDS & IMPURITIES

4 EDQM , 4 USP , 4 Others

otherSolutions
4 EDQM
4 USP
4 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,252

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

18DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

20,942,036

Annual Reports (USD Million)

Finished Drug Prices

295 RELATED EXCIPIENT COMPANIES

518EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 10405-02-4, Sanctura, Spasmex, Relaspium, Spasmo-lyt, Uraplex

Molecular Formula

C₂₅H₃₀ClNO₃

Molecular Weight

428.0 g/mol

InChI Key

RVCSYOQWLPPAOA-DHWZJIOFSA-M

FDA UNII

1E6682427E

1 2D Structure

Trospium Chloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(1R,5S)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride

2.1.2 InChI

InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23?;

2.1.3 InChI Key

RVCSYOQWLPPAOA-DHWZJIOFSA-M

2.1.4 Canonical SMILES

C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]

2.1.5 Isomeric SMILES

C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]

2.2 Other Identifiers

2.2.1 UNII

1E6682427E

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Azoniaspiro Compound Xvii

2. Azoniaspiro(3 Alpha-benziloyloxynortropane-8,1'- Pyrrolidine) Chloride

3. Ceris

4. Spasmex

5. Spasmo-lyt

6. Spasmo-rhoival Tc

7. Spasmo-urgenin

8. Spasmo-urgenin Tc

9. Spasmolyt

10. Trospi

11. Uraplex

12. Uraton

2.3.2 Depositor-Supplied Synonyms

1. 10405-02-4

2. Sanctura

3. Spasmex

4. Relaspium

5. Spasmo-lyt

6. Uraplex

7. Sanctura Xr

8. Regurin

9. Santura

10. Trospium Cl

11. Trospii Chloridum

12. Cloruro De Trospio

13. Spasmo 3

14. Chlorure De Trospium

15. Trospium (chloride)

16. Ip631

17. Spasmoplex

18. Ip-631

19. Trospium Chloride (sanctura)

20. 1e6682427e

21. Dsstox_cid_3724

22. Dsstox_rid_77166

23. Dsstox_gsid_23724

24. Keptan

25. Azoniaspiro Compound Xvii

26. Flotros

27. As Xvii

28. Rel-(1r,3r,5s)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-1'-ium Chloride

29. Cas-10405-02-4

30. Ncgc00167438-01

31. Ncgc00167438-02

32. Trospiumchlorid

33. Spasmed

34. Trofame

35. Trospikan

36. Trosec

37. Regurin Xl

38. Trospii Chloridum [inn-latin]

39. Cloruro De Trospio [inn-spanish]

40. Unii-1e6682427e

41. Chlorure De Trospium [inn-french]

42. [(1s,5r)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride

43. Einecs 233-875-4

44. Trospium Chloride [usan:usp:inn:ban:jan]

45. Schembl25785

46. Trospium Chloride [mi]

47. Trospium Chloride [inn]

48. Trospium Chloride [jan]

49. Chembl3084748

50. Schembl13836646

51. Trospium Chloride [usan]

52. Chebi:32270

53. Trospium Chloride [mart.]

54. Hms3656c16

55. Hms3884h08

56. Trospium Chloride [usp-rs]

57. Trospium Chloride [who-dd]

58. Bcp23426

59. Hy-b0461

60. Tox21_112442

61. 8-alpha-benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane Chloride

62. Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride

63. Bdbm50540489

64. Mfcd00865254

65. S2549

66. Akos015833209

67. Tox21_112442_1

68. Ac-4235

69. Ccg-268976

70. Trospium Chloride [orange Book]

71. Trospium Chloride [ep Monograph]

72. Trospium Chloride [usp Monograph]

73. Bcp0726000291

74. Sw219146-1

75. T3305

76. I11574

77. A800884

78. W-108827

79. Q27252312

80. 3alpha-hydroxyspiro(1alphah,5alphah-nortropane-8,1'-pyrrolidinium) Chloride Benzilate

81. (1s,3r,5r)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8lambda(5)-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium Chloride

82. [(1s,5r)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-oxidanyl-2,2-diphenyl-ethanoate Chloride

83. 2-hydroxy-2,2-diphenylacetic Acid [(1s,5r)-3-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]yl] Ester Chloride

84. 3.alpha.-hydroxy-spiro(1.alpha.h,5.alpha.h-nortropane-8,1'-pyrrolidinium) Chloride Benzilate

85. Rel-(1r,3r,5s)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-1'-iumchloride

86. Spiro (8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1alpha, 3beta, 5alpha)

87. Spiro(1-alpha-h,5-alpha-h-nortropane-8,1'-pyrrolidinium), 3-alpha-hydroxy-, Chloride, Benzilate

88. Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1.alpha., 3.beta., 5.alpha.)

89. Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium, 3-((hydroxydiphenylacetyl)oxy)-, Chloride, (1alpha,3beta,5alpha)-

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₀ClNO₃
Molecular Weight	428.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	427.1914215 g/mol
Monoisotopic Mass	427.1914215 g/mol
Topological Polar Surface Area	46.5 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	553
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Sanctura
Drug Label	SANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active Ingredient	Trospium chloride
Dosage Form	Tablet
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Allergan

2 of 6
Drug Name	Sanctura xr
Drug Label	SANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active Ingredient	Trospium chloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	60mg
Market Status	Prescription
Company	Allergan

3 of 6
Drug Name	Trospium chloride
PubMed Health	Trospium (By mouth)
Drug Classes	Urinary Antispasmodic
Drug Label	Trospium Chloride Extended-Release Capsules are an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, c
Active Ingredient	Trospium chloride
Dosage Form	Tablet; Capsule, extended release
Route	Oral
Strength	60mg; 20mg
Market Status	Prescription
Company	Actavis Labs Fl; Apotex; Glenmark Generics; Paddock

4 of 6
Drug Name	Sanctura
Drug Label	SANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active Ingredient	Trospium chloride
Dosage Form	Tablet
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Allergan

5 of 6
Drug Name	Sanctura xr
Drug Label	SANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1, 3, 5). The e...
Active Ingredient	Trospium chloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	60mg
Market Status	Prescription
Company	Allergan

6 of 6
Drug Name	Trospium chloride
PubMed Health	Trospium (By mouth)
Drug Classes	Urinary Antispasmodic
Drug Label	Trospium Chloride Extended-Release Capsules are an extended-release formulation of trospium chloride, a quaternary ammonium compound with the chemical name of Spiro [8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, c
Active Ingredient	Trospium chloride
Dosage Form	Tablet; Capsule, extended release
Route	Oral
Strength	60mg; 20mg
Market Status	Prescription
Company	Actavis Labs Fl; Apotex; Glenmark Generics; Paddock

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Granules India Limited

India

Antibody Engineering

Not Confirmed

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Lead Product(s) : Trospium Chloride

Therapeutic Area : Urology

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Granules India Limited announces approval of Trospium Chloride ER Capsules, 60 mg

Details : Trospium Chloride is a muscarinic antagonist it's generic has been approved for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

Brand Name : Sanctura-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

April 24, 2020

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