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Chemistry

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Also known as: Trovan, 147059-75-4, Trovafloxacin methanesulfonate, Trovafloxacin mesilate, Trovafloxacin monomethanesulfonate, Trovafloxacin (mesylate)
Molecular Formula
C21H19F3N4O6S
Molecular Weight
512.5  g/mol
InChI Key
DYNZICQDCVYXFW-GIPYJWDTSA-N
FDA UNII
0P1LKO80WN

Trovafloxacin Mesylate
1 2D Structure

Trovafloxacin Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid
2.1.2 InChI
InChI=1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16?;
2.1.3 InChI Key
DYNZICQDCVYXFW-GIPYJWDTSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)O.C1C2C(C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F
2.1.5 Isomeric SMILES
CS(=O)(=O)O.C1[C@@H]2[C@@H](C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F
2.2 Other Identifiers
2.2.1 UNII
0P1LKO80WN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alatrofloxacin

2. Alatrofloxacin Mesylate

3. Cp 116,517

4. Cp 116517

5. Cp-116,517

6. Cp-116517

7. Trovan

2.3.2 Depositor-Supplied Synonyms

1. Trovan

2. 147059-75-4

3. Trovafloxacin Methanesulfonate

4. Trovafloxacin Mesilate

5. Trovafloxacin Monomethanesulfonate

6. Trovafloxacin (mesylate)

7. Cp-99219-27

8. Trovafloxacin Mesylate [usan]

9. 0p1lko80wn

10. Cp 99219

11. Chebi:77568

12. Cp-99,219-27

13. Dsstox_cid_25701

14. Dsstox_rid_81073

15. Dsstox_gsid_45701

16. 7-((1r,5s,6s)-6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, Monomethanesulfonate

17. Trovafloxacin Mesylate (usan)

18. 1,8-naphthyridine-3-carboxylic Acid, 7-[(1alpha,5alpha,6alpha)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, Methanesulfonate (1:1)

19. Rel-7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Compound With Methanesulfonic Acid (1:1)

20. Cas-147059-75-4

21. Unii-0p1lko80wn

22. Turvel

23. Trovafloxacin Sulfate

24. Trovan (tn)

25. Cp 99219 Mesylate

26. Trovafloxacin Monomesylate

27. Ncgc00064532-02

28. Cp 99219-27

29. Schembl40874

30. Schembl40875

31. Chembl1200779

32. Dtxsid0045701

33. Hms3260e16

34. Tox21_110980

35. Tox21_500107

36. Trovafloxacin Mesylate [vandf]

37. Akos000280396

38. Akos015914051

39. Tox21_110980_1

40. Trovafloxacin Mesilate [mart.]

41. Ccg-221411

42. Trovafloxacin Mesilate [who-dd]

43. Trovafloxacin Mesylate, >98% (hplc)

44. Ncgc00260792-01

45. Ncgc00263538-01

46. 1,8-naphthyridine-3-carboxylic Acid, 7-(6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-(1alpha,5alpha,6alpha)-, Monomethanesulfonate

47. Trovafloxacin Methanesulfonate [mi]

48. Hy-103399

49. Trovafloxacin Mesylate [orange Book]

50. Cs-0027824

51. D02123

52. E98675

53. J-008308

54. J-690188

55. Q27147183

56. (1r,5s,6s)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5-oxo-5,8-dihydro-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hexan-6-aminium Methanesulfonate

57. 1,8-naphthyridine-3-carboxylic Acid, 7-((1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, Methanesulfonate (1:1)

58. 1,8-naphthyridine-3-carboxylic Acid, 7-(6-amino-3-azabicyclo(3.1.0)hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-(1.alpha.,5.alpha.,6.alpha.)- Monomethanesulfonate

59. 171335-83-4

60. 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Compound With Methanesulfonic Acid (1:1)

61. 7-[(1?,5?,6?)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Mesylate

62. 7-[(1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 512.5 g/mol
Molecular Formula C21H19F3N4O6S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count13
Rotatable Bond Count3
Exact Mass512.09774000 g/mol
Monoisotopic Mass512.09774000 g/mol
Topological Polar Surface Area163 Ų
Heavy Atom Count35
Formal Charge0
Complexity863
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Trovafloxacin is a synthetic broad spectrum quinolone antibacterial agent indicated for the treatment of the following infections in adults:

- Pneumonia: Community Acquired Pneumonia and Nosocomial Pneumonia (mild, moderate, and severe).

Note: Efficacy in patients with very severe nosocomial pneumonia and in particular infections due to less susceptible pathogens e. g. P. aeruginosa, has not been established. See also section 4. 2.

- Acute Exacerbations of Chronic Bronchitis

- Acute Sinusitis

- Complicated Intra-abdominal Infections and Acute Pelvic Infections

- Salpingitis

- Uncomplicated Gonococcal Urethritis and Cervicitis

- Chlamydial Cervicitis

- Complicated Skin and Soft Tissue Infections

Consideration should be given to official guidance on the appropriate use of antibacterial agents.


Trovafloxacin is a synthetic broad spectrum quinolone antibacterial agent indicated for the treatment of the following infections in adults:

Pneumonia:

- Community Acquired Pneumonia and Nosocomial Pneumonia (mild, moderate, and severe).

Note: Efficacy in patients with very severe nosocomial pneumonia and in particular infections due to less susceptible pathogens e. g. P. aeruginosa, has not been established. See also section 4. 2.

- Acute Exacerbations of Chronic Bronchitis

- Acute Sinusitis

- Complicated Intra-abdominal Infections and Acute Pelvic Infections

- Salpingitis

- Uncomplicated Gonococcal Urethritis and Cervicitis

- Chlamydial Cervicitis

- Complicated Skin and Soft Tissue Infections

Consideration should be given to official guidance on the appropriate use of antibacterial agents.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)


Anti-Infective Agents

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)


5.2 ATC Code

J01MA13


J01MA13


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Looking for 171335-83-4 / Trovafloxacin Mesylate API manufacturers, exporters & distributors?

Trovafloxacin Mesylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Trovafloxacin Mesylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Trovafloxacin Mesylate manufacturer or Trovafloxacin Mesylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Trovafloxacin Mesylate manufacturer or Trovafloxacin Mesylate supplier.

PharmaCompass also assists you with knowing the Trovafloxacin Mesylate API Price utilized in the formulation of products. Trovafloxacin Mesylate API Price is not always fixed or binding as the Trovafloxacin Mesylate Price is obtained through a variety of data sources. The Trovafloxacin Mesylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Trovafloxacin Mesylate

Synonyms

Trovan, 147059-75-4, Trovafloxacin methanesulfonate, Trovafloxacin mesilate, Trovafloxacin monomethanesulfonate, Trovafloxacin (mesylate)

Cas Number

171335-83-4

Unique Ingredient Identifier (UNII)

0P1LKO80WN

Trovafloxacin Mesylate Manufacturers

A Trovafloxacin Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trovafloxacin Mesylate, including repackagers and relabelers. The FDA regulates Trovafloxacin Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trovafloxacin Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Trovafloxacin Mesylate Suppliers

A Trovafloxacin Mesylate supplier is an individual or a company that provides Trovafloxacin Mesylate active pharmaceutical ingredient (API) or Trovafloxacin Mesylate finished formulations upon request. The Trovafloxacin Mesylate suppliers may include Trovafloxacin Mesylate API manufacturers, exporters, distributors and traders.

Trovafloxacin Mesylate GMP

Trovafloxacin Mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Trovafloxacin Mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Trovafloxacin Mesylate GMP manufacturer or Trovafloxacin Mesylate GMP API supplier for your needs.

Trovafloxacin Mesylate CoA

A Trovafloxacin Mesylate CoA (Certificate of Analysis) is a formal document that attests to Trovafloxacin Mesylate's compliance with Trovafloxacin Mesylate specifications and serves as a tool for batch-level quality control.

Trovafloxacin Mesylate CoA mostly includes findings from lab analyses of a specific batch. For each Trovafloxacin Mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Trovafloxacin Mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Trovafloxacin Mesylate EP), Trovafloxacin Mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Trovafloxacin Mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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