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Chemistry

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Also known as: Acetic acid;tert-butyl n-[(2s)-1-[[(2s)-1-[[(2s)-5-(diaminomethylideneamino)-1-[(5-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate, Tryptase from human lung, buffered aqueous solution, >=5 units/mg protein
Molecular Formula
C35H47N7O10
Molecular Weight
725.8  g/mol
InChI Key
WGWZNYKOUXOZTC-NAGNLMCHSA-N

Trypsin
A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
1 2D Structure

Trypsin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
acetic acid;tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(5-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
2.1.2 InChI
InChI=1S/C33H43N7O8.C2H4O2/c1-19-15-21(17-26-22(19)12-13-27(42)47-26)37-28(43)23(11-8-14-36-31(34)35)38-30(45)25(18-41)39-29(44)24(16-20-9-6-5-7-10-20)40-32(46)48-33(2,3)4;1-2(3)4/h5-7,9-10,12-13,15,17,23-25,41H,8,11,14,16,18H2,1-4H3,(H,37,43)(H,38,45)(H,39,44)(H,40,46)(H4,34,35,36);1H3,(H,3,4)/t23-,24-,25-;/m0./s1
2.1.3 InChI Key
WGWZNYKOUXOZTC-NAGNLMCHSA-N
2.1.4 Canonical SMILES
CC1=CC(=CC2=C1C=CC(=O)O2)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C.CC(=O)O
2.1.5 Isomeric SMILES
CC1=CC(=CC2=C1C=CC(=O)O2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C.CC(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Alpha Tryptase

2. Alpha Tryptases

3. Alpha-tryptase

4. Alpha-tryptases

5. Beta Tryptase

6. Beta Tryptases

7. Beta-tryptase

8. Beta-tryptases

9. Delta Tryptase

10. Delta Tryptases

11. Delta-tryptase

12. Delta-tryptases

13. Gamma Tryptase

14. Gamma Tryptases

15. Gamma-tryptase

16. Gamma-tryptases

17. Mast Cell Tryptase

18. Skin Tryptase

19. Tryptase, Skin

20. Tryptases

2.2.2 Depositor-Supplied Synonyms

1. Acetic Acid;tert-butyl N-[(2s)-1-[[(2s)-1-[[(2s)-5-(diaminomethylideneamino)-1-[(5-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate

2. Tryptase From Human Lung, Buffered Aqueous Solution, >=5 Units/mg Protein

2.2.3 Other Synonyms

1. Trypsin Complex

2.3 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 725.8 g/mol
Molecular Formula C35H47N7O10
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count11
Rotatable Bond Count16
Exact Mass725.33844072 g/mol
Monoisotopic Mass725.33844072 g/mol
Topological Polar Surface Area274 Ų
Heavy Atom Count52
Formal Charge0
Complexity1220
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

USDMF

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 38288

Submission : 2023-05-16

Status : Active

Type : II

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Eli Lilly And Co

U.S.A

USDMF

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Pharma, Lab & Chemical Expo
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Pharma, Lab & Chemical Expo
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Novo Nordisk As

Denmark

USDMF

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Novo Nordisk As

Denmark
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 1537

Submission : 1970-06-09

Status : Inactive

Type : II

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Pharma, Lab & Chemical Expo
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Pharma, Lab & Chemical Expo
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 39076

Submission : 2023-10-27

Status : Active

Type : II

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Sigma F And D Div Ltd

U.S.A

USDMF

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Pharma, Lab & Chemical Expo
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 6298

Submission : 1986-04-23

Status : Inactive

Type : II

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Pharma, Lab & Chemical Expo
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Pharma, Lab & Chemical Expo
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Pharma, Lab & Chemical Expo
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 162

Submission : 1955-01-27

Status : Inactive

Type : II

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JDMF

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Culture medium/Culture additives Trypsin-EDTA, liquid A31476

Registration Number : 229MF40004

Registrant's Address : 3175 Staley Road Grand Island, New York 14072-0068

Initial Date of Registration : 2017-01-30

Latest Date of Registration : 2018-10-30

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Listed Suppliers

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TRYPSIN

About the Company : The company is in the business of manufacturing and marketing botanical extracts and nutraceuticals formulations to both domestic and global customers. The products include health/...

The company is in the business of manufacturing and marketing botanical extracts and nutraceuticals formulations to both domestic and global customers. The products include health/dietary supplements for improving the overall wellness/prevention of diseases, ingredients for functional foods, food colors, and extracts. The company exports to around 35 countries in Europe, US, and Japan, with strong relations with global majors. The company has production facilities near Bengaluru (Peenya, Tumkur, Bidadi), Bhatkal, Hyderabad and Pune.
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Trypsin

About the Company : The company is a professional manufacturer of active biological extracts. We adhere to the market-oriented business philosophy. The international and domestic markets take advantag...

The company is a professional manufacturer of active biological extracts. We adhere to the market-oriented business philosophy. The international and domestic markets take advantage of China's abundant raw material resources to develop animal organ extracts. The company mainly produces trypsin and trypsin. , chymotrypsin, trypsin enzymes , pancreatic kallikrein, pepsin, elastase, sodium, cytochrome C, hemoglobin, bovine liver extract, chondroitin sulfate, and other products, marketing the United States, Germany, Japan, Korea, etc. Countries and regions have established good long-term partnerships with customers around the world.
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Drugs in Development

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Details:

Through the acquisition, Sun Pharma strengthen its anti-inflammatory portfolio by adding Disperzyme (bromelain), Disperzyme-CD and Phlogam from Aksigen Hospital Care.


Lead Product(s): Bromelain,Trypsin,Rutin

Therapeutic Area: Neurology Brand Name: Disperzyme

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Sun Pharmaceutical Industries Limited

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Acquisition January 30, 2023

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Antibody Engineering
Not Confirmed
Antibody Engineering
Not Confirmed

Details : Through the acquisition, Sun Pharma strengthen its anti-inflammatory portfolio by adding Disperzyme (bromelain), Disperzyme-CD and Phlogam from Aksigen Hospital Care.

Brand Name : Disperzyme

Molecule Type : Small molecule

Upfront Cash : Undisclosed

January 30, 2023

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