Find TT-00420 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Wz9tj0l9y8, Tt-00420, 2230490-29-4, Pyrazolo(4,3-b)pyrido(4,3-e)(1,4)diazepine, 5-(2-chlorophenyl)-1,2-dihydro-3-methyl-8-(4-morpholinyl)-, Tinengotinib [inn], Unii-wz9tj0l9y8
Molecular Formula
C20H19ClN6O
Molecular Weight
394.9  g/mol
InChI Key
DQFCVOOFMXEPOC-UHFFFAOYSA-N
FDA UNII
WZ9TJ0L9Y8

TT-00420
Tinengotinib is an orally available small molecule inhibitor of Aurora kinases (AKs) A and B, Janus kinases (JAKs), fibroblast growth factor receptors (FGFRs) and vascular endothelial growth factor receptors (VEGFRs), with potential antineoplastic and immunomodulatory activities. Upon oral administration, tinengotinib selectively binds to and inhibits AKs A and B, which inhibit cell division in tumor cells that overexpress AKs. Tinengotinib also targets JAKs that are involved in cytokine signaling and inflammation, and FGFRs and VEGFRs, which are overexpressed in the microenvironment (TME) and contribute to neovascularization, tumor growth and metastasis. These kinases are overexpressed by a wide variety of cancer cell types and drive tumor cell proliferation.
1 2D Structure

TT-00420

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[9-(2-chlorophenyl)-6-methyl-2,4,5,8,12-pentazatricyclo[8.4.0.03,7]tetradeca-1(14),3,6,8,10,12-hexaen-13-yl]morpholine
2.1.2 InChI
InChI=1S/C20H19ClN6O/c1-12-18-20(26-25-12)23-16-10-17(27-6-8-28-9-7-27)22-11-14(16)19(24-18)13-4-2-3-5-15(13)21/h2-5,10-11H,6-9H2,1H3,(H2,23,25,26)
2.1.3 InChI Key
DQFCVOOFMXEPOC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C2C(=NN1)NC3=CC(=NC=C3C(=N2)C4=CC=CC=C4Cl)N5CCOCC5
2.2 Other Identifiers
2.2.1 UNII
WZ9TJ0L9Y8
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Wz9tj0l9y8

2. Tt-00420

3. 2230490-29-4

4. Pyrazolo(4,3-b)pyrido(4,3-e)(1,4)diazepine, 5-(2-chlorophenyl)-1,2-dihydro-3-methyl-8-(4-morpholinyl)-

5. Tinengotinib [inn]

6. Unii-wz9tj0l9y8

7. Schembl20266964

8. Gtpl11887

9. Example 6 [us10889586b2]

10. Tt00420

11. Hy-145601

12. Cs-0376684

13. 5-(2-chlorophenyl)-3-methyl-8-(morpholin-4-yl)-1,10-dihydropyrazolo[4,3-b]pyrido[4,3-e][1,4]diazepine

2.4 Create Date
2019-01-26
3 Chemical and Physical Properties
Molecular Weight 394.9 g/mol
Molecular Formula C20H19ClN6O
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass394.1308869 g/mol
Monoisotopic Mass394.1308869 g/mol
Topological Polar Surface Area78.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity585
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

TT-00420 Manufacturers

A TT-00420 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TT-00420, including repackagers and relabelers. The FDA regulates TT-00420 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TT-00420 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TT-00420 Suppliers

A TT-00420 supplier is an individual or a company that provides TT-00420 active pharmaceutical ingredient (API) or TT-00420 finished formulations upon request. The TT-00420 suppliers may include TT-00420 API manufacturers, exporters, distributors and traders.

TT-00420 GMP

TT-00420 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TT-00420 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TT-00420 GMP manufacturer or TT-00420 GMP API supplier for your needs.

TT-00420 CoA

A TT-00420 CoA (Certificate of Analysis) is a formal document that attests to TT-00420's compliance with TT-00420 specifications and serves as a tool for batch-level quality control.

TT-00420 CoA mostly includes findings from lab analyses of a specific batch. For each TT-00420 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TT-00420 may be tested according to a variety of international standards, such as European Pharmacopoeia (TT-00420 EP), TT-00420 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TT-00420 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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