Find TTC-352 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Ttc-352, 1607819-68-0, 65ilh3y0mi, Chembl3763743, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-benzo[b]thiophene-6-ol
Molecular Formula
C20H13FO3S
Molecular Weight
352.4  g/mol
InChI Key
UDBMVVLTKJMPCJ-UHFFFAOYSA-N
FDA UNII
65ILH3Y0MI

TTC-352
Selective Human Estrogen-receptor Alpha Partial Agonist TTC-352 is a benzothiophene and orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring 17beta-estradiol (E2) and targets and binds to ERa located in the nucleus. This causes translocation of ERa to extranuclear sites. Nuclear export of ERa prevents normal ER-mediated signaling and inhibits proliferation of ER-positive tumor cells. TTC-352 causes tumor regression of tamoxifen (TAM)-resistant (TR) tumor cells which often overexpress protein kinase C alpha (PKCalpha; PKCa). PKCa expression is associated with poor patient survival and breast cancer aggressiveness and may predict tumor responses to E2, E2-like compounds and ShERPAs. Unlike E2 and E2-like compounds, TTC-352 does not cause endometrial proliferation.
1 2D Structure

TTC-352

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophen-6-ol
2.1.2 InChI
InChI=1S/C20H13FO3S/c21-13-3-1-12(2-4-13)19-17-10-7-15(23)11-18(17)25-20(19)24-16-8-5-14(22)6-9-16/h1-11,22-23H
2.1.3 InChI Key
UDBMVVLTKJMPCJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1C2=C(SC3=C2C=CC(=C3)O)OC4=CC=C(C=C4)O)F
2.2 Other Identifiers
2.2.1 UNII
65ILH3Y0MI
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Ttc-352

2. 1607819-68-0

3. 65ilh3y0mi

4. Chembl3763743

5. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol

6. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-benzo[b]thiophene-6-ol

7. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)benzo(b)thiophene-6-ol

8. Selective Human Estrogen-receptor Alpha Partial Agonist Ttc-352

9. Benzo(b)thiophene-6-ol, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-

10. Unii-65ilh3y0mi

11. Schembl15658409

12. Bdbm50145856

13. J3.603.123i

14. 2-(4-hydroxyphenoxy)-3-(4-fluorophenyl)benzo[b]thiophene-6-ol

15. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophen-6-ol

16. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)benzo[b]thiophen-6-ol

17. 3-(4-fluorophenyl)-2-(4-hydroxyphenoxyl)benzo[b]thiophen-6-ol

18. V9j

2.4 Create Date
2014-06-09
3 Chemical and Physical Properties
Molecular Weight 352.4 g/mol
Molecular Formula C20H13FO3S
XLogP35.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass352.05694361 g/mol
Monoisotopic Mass352.05694361 g/mol
Topological Polar Surface Area77.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity435
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1607819-68-0 / TTC-352 API manufacturers, exporters & distributors?

TTC-352 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of TTC-352 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right TTC-352 manufacturer or TTC-352 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred TTC-352 manufacturer or TTC-352 supplier.

PharmaCompass also assists you with knowing the TTC-352 API Price utilized in the formulation of products. TTC-352 API Price is not always fixed or binding as the TTC-352 Price is obtained through a variety of data sources. The TTC-352 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

TTC-352

Synonyms

1607819-68-0, 65ilh3y0mi, Chembl3763743, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-benzo[b]thiophene-6-ol, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)benzo(b)thiophene-6-ol

Cas Number

1607819-68-0

Unique Ingredient Identifier (UNII)

65ILH3Y0MI

About TTC-352

Selective Human Estrogen-receptor Alpha Partial Agonist TTC-352 is a benzothiophene and orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring 17beta-estradiol (E2) and targets and binds to ERa located in the nucleus. This causes translocation of ERa to extranuclear sites. Nuclear export of ERa prevents normal ER-mediated signaling and inhibits proliferation of ER-positive tumor cells. TTC-352 causes tumor regression of tamoxifen (TAM)-resistant (TR) tumor cells which often overexpress protein kinase C alpha (PKCalpha; PKCa). PKCa expression is associated with poor patient survival and breast cancer aggressiveness and may predict tumor responses to E2, E2-like compounds and ShERPAs. Unlike E2 and E2-like compounds, TTC-352 does not cause endometrial proliferation.

TTC-352 Manufacturers

A TTC-352 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TTC-352, including repackagers and relabelers. The FDA regulates TTC-352 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TTC-352 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TTC-352 Suppliers

A TTC-352 supplier is an individual or a company that provides TTC-352 active pharmaceutical ingredient (API) or TTC-352 finished formulations upon request. The TTC-352 suppliers may include TTC-352 API manufacturers, exporters, distributors and traders.

TTC-352 GMP

TTC-352 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TTC-352 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TTC-352 GMP manufacturer or TTC-352 GMP API supplier for your needs.

TTC-352 CoA

A TTC-352 CoA (Certificate of Analysis) is a formal document that attests to TTC-352's compliance with TTC-352 specifications and serves as a tool for batch-level quality control.

TTC-352 CoA mostly includes findings from lab analyses of a specific batch. For each TTC-352 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TTC-352 may be tested according to a variety of international standards, such as European Pharmacopoeia (TTC-352 EP), TTC-352 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TTC-352 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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