Find Tucidinostat manufacturers, exporters & distributors on PharmaCompass

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

Virtual Booth

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Epidaza, 1616493-44-7, Hbi-8000, Cs-055, Cs055, 743438-44-0

Molecular Formula

C₂₂H₁₉FN₄O₂

Molecular Weight

390.4 g/mol

InChI Key

SZMJVTADHFNAIS-BJMVGYQFSA-N

FDA UNII

87CIC980Y0

Tucidinostat is an orally bioavailable benzamide-type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Upon administration, tucidinostat binds to and inhibits HDACs, leading to an increase of acetylation levels of histone proteins. This agent also inhibits the expression of kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide-type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life.

1 2D Structure

Tucidinostat

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide

2.1.2 InChI

InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+

2.1.3 InChI Key

SZMJVTADHFNAIS-BJMVGYQFSA-N

2.1.4 Canonical SMILES

C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N

2.1.5 Isomeric SMILES

C1=CC(=CN=C1)/C=C/C(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N

2.2 Other Identifiers

2.2.1 UNII

87CIC980Y0

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (e)-n-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

2. Hbi-8000

2.3.2 Depositor-Supplied Synonyms

1. Epidaza

2. 1616493-44-7

3. Hbi-8000

4. Cs-055

5. Cs055

6. 743438-44-0

7. (e)-n-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

8. De-5-fluoro 4-fluorochidamide

9. Tucidinostat [usan]

10. Chidamide [who-dd]

11. 87cic980y0

12. Cs 055

13. N-(2-amino-4-fluorophenyl)-4-[[[(e)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide

14. N-(2-amino-4-fluorophenyl)-4-(((1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)benzamide

15. Benzamide, N-(2-amino-4-fluorophenyl)-4-((((2e)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)-

16. Benzamide, N-(2-amino-4-fluorophenyl)-4-(((1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)-

17. Tucidinostat Hcl

18. Epidaza In China

19. Epidaza (tn)

20. Tucidinostat [inn]

21. Tucidinostat [jan]

22. Tucidinostat [who-dd]

23. Unii-87cic980y0

24. Tucidinostat (jan/usan/inn)

25. Chembl3621988

26. Schembl13815849

27. Chebi:135918

28. Dtxsid701032295

29. Ex-a3245

30. Bdbm50457079

31. Db06334

32. Chidamide; Hbi-8000; Cs-055 Hcl

33. Bs-15501

34. Hy-109015

35. Cs-0030513

36. A51185

37. D10993

38. A899933

39. Q19903814

40. Benzamide, N-(2-amino-4-fluorophenyl)-4-(((1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)-benzamide, N-(2-amino-4-fluorophenyl)-4-((((2e)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)-

41. N-(2-amino-4-fluorophenyl)-4-(((2e)-3-(pyridin-3-yl)prop- 2-enamido)methyl)benzamide

42. N-(2-amino-4-fluorophenyl)-4-{(3-(pyridin-3-yl)prop-2-enamido)methyl}benzamide N-(2-amino-4-fluorophenyl)-4-{((2e)-3-(pyridin-3-yl)prop-2-enamido)methyl}benzamide

2.4 Create Date

2007-02-07

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₁₉FN₄O₂
Molecular Weight	390.4 g/mol
XLogP3	2.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	390.14920402 g/mol
Monoisotopic Mass	390.14920402 g/mol
Topological Polar Surface Area	97.1 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	577
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in cancer/tumors (unspecified).

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

Chidamide is an orally bioavailable histone deacetylase (HDAC) inhibitor derived from the benzamide class. Histone deacetylase inhibitors are a class of cancer drugs that induce selective regulation of gene expression in cancer cells. [HUYA Biosciences Press Release]

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

ABOUT THIS PAGE

Tucidinostat Manufacturers

A Tucidinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tucidinostat, including repackagers and relabelers. The FDA regulates Tucidinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tucidinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tucidinostat Suppliers

A Tucidinostat supplier is an individual or a company that provides Tucidinostat active pharmaceutical ingredient (API) or Tucidinostat finished formulations upon request. The Tucidinostat suppliers may include Tucidinostat API manufacturers, exporters, distributors and traders.

click here to find a list of Tucidinostat suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tucidinostat USDMF

A Tucidinostat DMF (Drug Master File) is a document detailing the whole manufacturing process of Tucidinostat active pharmaceutical ingredient (API) in detail. Different forms of Tucidinostat DMFs exist exist since differing nations have different regulations, such as Tucidinostat USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tucidinostat DMF submitted to regulatory agencies in the US is known as a USDMF. Tucidinostat USDMF includes data on Tucidinostat's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tucidinostat USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tucidinostat suppliers with USDMF on PharmaCompass.

Tucidinostat GMP

Tucidinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tucidinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tucidinostat GMP manufacturer or Tucidinostat GMP API supplier for your needs.

Tucidinostat CoA

A Tucidinostat CoA (Certificate of Analysis) is a formal document that attests to Tucidinostat's compliance with Tucidinostat specifications and serves as a tool for batch-level quality control.

Tucidinostat CoA mostly includes findings from lab analyses of a specific batch. For each Tucidinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tucidinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Tucidinostat EP), Tucidinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tucidinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.