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Chemistry

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Also known as: Tulmimetostat [inn], Ouq4n85z0b, 1,3-benzodioxole-5-carboxamide, 7-chloro-n-((1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl)methyl)-2-(trans-4-(3-methoxy-1-azetidinyl)cyclohexyl)-2,4-dimethyl-, (2r)-, 2567686-02-4, Unii-ouq4n85z0b, Schembl22915712
Molecular Formula
C28H36ClN3O5S
Molecular Weight
562.1  g/mol
InChI Key
CAAWBLRXQXMGHV-WOLMIXIISA-N
FDA UNII
OUQ4N85Z0B

Tulmimetostat
Tulmimetostat is an orally available selective inhibitor of the histone lysine methyltransferase (HMT) enhancer of zeste homolog 2 (EZH2), with potential antineoplastic activity. Upon oral administration, tulmimetostat selectively targets, binds to and inhibits the activity of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 on lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased proliferation of EZH2-expressing cancer cells. EZH2, an HMT class enzyme and the catalytic subunit of the polycomb repressive complex 2 (PRC2), is overexpressed or mutated in a variety of cancer cells and plays a key role in tumor cell proliferation; its expression is correlated with tumor initiation, progression, stem cell self-renewal, migration and angiogenesis.
1 2D Structure

Tulmimetostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R)-7-chloro-2-[4-(3-methoxyazetidin-1-yl)cyclohexyl]-2,4-dimethyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1,3-benzodioxole-5-carboxamide
2.1.2 InChI
InChI=1S/C28H36ClN3O5S/c1-15-10-23(38-5)21(27(34)31-15)12-30-26(33)20-11-22(29)25-24(16(20)2)36-28(3,37-25)17-6-8-18(9-7-17)32-13-19(14-32)35-4/h10-11,17-19H,6-9,12-14H2,1-5H3,(H,30,33)(H,31,34)/t17?,18?,28-/m1/s1
2.1.3 InChI Key
CAAWBLRXQXMGHV-WOLMIXIISA-N
2.1.4 Canonical SMILES
CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)OC(O3)(C)C4CCC(CC4)N5CC(C5)OC)Cl)SC
2.1.5 Isomeric SMILES
CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)O[C@@](O3)(C)C4CCC(CC4)N5CC(C5)OC)Cl)SC
2.2 Other Identifiers
2.2.1 UNII
OUQ4N85Z0B
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Tulmimetostat [inn]

2. Ouq4n85z0b

3. 1,3-benzodioxole-5-carboxamide, 7-chloro-n-((1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl)methyl)-2-(trans-4-(3-methoxy-1-azetidinyl)cyclohexyl)-2,4-dimethyl-, (2r)-

4. 2567686-02-4

5. Unii-ouq4n85z0b

6. Schembl22915712

7. Schembl22915728

8. Schembl22922941

9. Cpi0209

10. Cpi-0209 [who-dd]

11. Cpi-0209

12. Hy-145602

13. Cs-0376691

2.4 Create Date
2021-02-21
3 Chemical and Physical Properties
Molecular Weight 562.1 g/mol
Molecular Formula C28H36ClN3O5S
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass561.2064201 g/mol
Monoisotopic Mass561.2064201 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count38
Formal Charge0
Complexity993
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Tulmimetostat Manufacturers

A Tulmimetostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tulmimetostat, including repackagers and relabelers. The FDA regulates Tulmimetostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tulmimetostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tulmimetostat Suppliers

A Tulmimetostat supplier is an individual or a company that provides Tulmimetostat active pharmaceutical ingredient (API) or Tulmimetostat finished formulations upon request. The Tulmimetostat suppliers may include Tulmimetostat API manufacturers, exporters, distributors and traders.

Tulmimetostat GMP

Tulmimetostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tulmimetostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tulmimetostat GMP manufacturer or Tulmimetostat GMP API supplier for your needs.

Tulmimetostat CoA

A Tulmimetostat CoA (Certificate of Analysis) is a formal document that attests to Tulmimetostat's compliance with Tulmimetostat specifications and serves as a tool for batch-level quality control.

Tulmimetostat CoA mostly includes findings from lab analyses of a specific batch. For each Tulmimetostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tulmimetostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Tulmimetostat EP), Tulmimetostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tulmimetostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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