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Chemistry

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Also known as: Hm43239, Hm-43239, 2569527-64-4, 2294874-49-8, 2-pyrimidinamine, 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethyl-1-piperazinyl)methyl)phenyl)-4-(6-methyl-1h-indol-3-yl)-, rel-, 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethylpiperazine-1-yl) methyl) phenyl)-4-(6-methyl-1hindol-3-yl) pyrimidin-2-amine
Molecular Formula
C29H33ClN6
Molecular Weight
501.1  g/mol
InChI Key
FZLSDZZNPXXBBB-KDURUIRLSA-N
FDA UNII
C0WUS7XXE9

Tuspetinib
FLT3 Inhibitor HM43239 is a selective, reversible type I inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) with potential antineoplastic activity. Upon administration of FLT3 inhibitor HM43239, it reversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias.
1 2D Structure

Tuspetinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine
2.1.2 InChI
InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
2.1.3 InChI Key
FZLSDZZNPXXBBB-KDURUIRLSA-N
2.1.4 Canonical SMILES
CC1CN(CC(N1)C)CC2=CC(=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=C4C=CC(=C5)C)Cl)C6CC6
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@@H](N1)C)CC2=CC(=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=C4C=CC(=C5)C)Cl)C6CC6
2.2 Other Identifiers
2.2.1 UNII
C0WUS7XXE9
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Hm43239

2. Hm-43239

3. 2569527-64-4

4. 2294874-49-8

5. 2-pyrimidinamine, 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethyl-1-piperazinyl)methyl)phenyl)-4-(6-methyl-1h-indol-3-yl)-, Rel-

6. 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethylpiperazine-1-yl) Methyl) Phenyl)-4-(6-methyl-1hindol-3-yl) Pyrimidin-2-amine

7. Tuspetinib

8. 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethylpiperazin-1-yl)methyl)phenyl)-4-(6-methyl-1h-indol-3-yl)pyrimidin-2-amine

9. 5-chloro-n-[3-cyclopropyl-5-[[(3r,5s)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(6-methyl-1h-indol-3-yl)pyrimidin-2-amine

10. Unii-c0wus7xxe9

11. Schembl21629038

12. Gtpl12010

13. Us10870639, Example 8

14. Bdbm476700

15. Glxc-25333

16. Ex-a5352

17. Example 8 [us10870639b2]

18. Db15343

19. Hy-145015

20. Cs-0312139

21. 5-chloro-n-(3-cyclopropyl-5-(((3r,5s)-3,5-dimethylpiperazine-1-yl)methyl)phenyl)-4-(6-methyl-1h-indole-3-yl)pyrimidine-2-amine

22. 5-chloro-n-(3-cyclopropyl-5-(((3s,5r)-3,5-dimethylpiperazin-1-yl)methyl)phenyl)-4-(6-methyl-1h-indol-3-yl)pyrimidin-2-amine

2.4 Create Date
2018-12-16
3 Chemical and Physical Properties
Molecular Weight 501.1 g/mol
Molecular Formula C29H33ClN6
XLogP35.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass500.2455228 g/mol
Monoisotopic Mass500.2455228 g/mol
Topological Polar Surface Area68.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity725
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Tuspetinib Manufacturers

A Tuspetinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tuspetinib, including repackagers and relabelers. The FDA regulates Tuspetinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tuspetinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tuspetinib Suppliers

A Tuspetinib supplier is an individual or a company that provides Tuspetinib active pharmaceutical ingredient (API) or Tuspetinib finished formulations upon request. The Tuspetinib suppliers may include Tuspetinib API manufacturers, exporters, distributors and traders.

Tuspetinib GMP

Tuspetinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tuspetinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tuspetinib GMP manufacturer or Tuspetinib GMP API supplier for your needs.

Tuspetinib CoA

A Tuspetinib CoA (Certificate of Analysis) is a formal document that attests to Tuspetinib's compliance with Tuspetinib specifications and serves as a tool for batch-level quality control.

Tuspetinib CoA mostly includes findings from lab analyses of a specific batch. For each Tuspetinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tuspetinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Tuspetinib EP), Tuspetinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tuspetinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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