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Chemistry

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Also known as: Tyloxapol, 25301-02-4, Tyloxypal, Triton wr-1339, Superinone, Alevaire
Molecular Formula
C17H28O3
Molecular Weight
280.4  g/mol
InChI Key
MDYZKJNTKZIUSK-UHFFFAOYSA-N

Tyloxapol API
Tyloxapol is a non-ionic detergent often used as a surfactant.
1 2D Structure

Tyloxapol API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
2.1.2 InChI
InChI=1S/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2
2.1.3 InChI Key
MDYZKJNTKZIUSK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Alevaire

2. Enuclene

3. Formaldehyde, Polymer With Oxirane And 4-(1,1,3,3-tetramethylbutyl)phenol

4. Oxyethylated Tertiary Octylphenol Formaldehyde Polymer

5. P-isooctylpolyoxyethylenephenol Formaldehyde Polymer

6. Polyhydroxyethyl-tert-octylphenolformaldehyde

7. Superinone

8. Supervent

9. Translight

10. Triton A 20

11. Triton Wr 1339

12. Triton Wr-1339

13. Tyloxapol

14. Tyroxapol

15. Wr-1339

2.2.2 Depositor-Supplied Synonyms

1. Tyloxapol

2. 25301-02-4

3. Tyloxypal

4. Triton Wr-1339

5. Superinone

6. Alevaire

7. Nsc90255

8. Formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol

9. Triton A-20

10. Formaldehyde, Polymer With Oxirane And4-(1,1,3,3-tetramethylbutyl)phenolother Ca Index Names:oxirane, Polymer With Formaldehyde And4-(1,1,3,3-tetramethylbutyl)phenolphenol, 4-(1,1,3,3-tetramethylbutyl)-, Polymer With Formaldehyde Andoxirane

11. Superiuone

12. Component Of Alevaire

13. Formaldehyde; Oxirane; 4-(1,1,3,3-tetramethylbutyl)phenol

14. Schembl181284

15. Dtxsid30179950

16. Chebi:141517

17. Nsc-90255

18. Akos026749862

19. Formaldehyde,1,3,3-tetra Methylbutyl)phenol

20. Ab01563398_01

21. Q7860340

22. Ethoxylated P-tert-octylphenol Formaldehyde Polymer

23. Wln: /qr Dx1&1&1x1&1&1/ &/*o2*/ &/*o1*/

24. Phenol,1,3,3-tetramethylbutyl)-, Polymer With Ethylene Oxide And Formaldehyde

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 280.4 g/mol
Molecular Formula C17H28O3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass280.20384475 g/mol
Monoisotopic Mass280.20384475 g/mol
Topological Polar Surface Area49.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity204
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Tyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.


5 Pharmacology and Biochemistry
5.1 Pharmacology

It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.


5.2 MeSH Pharmacological Classification

Surface-Active Agents

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)


Detergents

Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)


5.3 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05C - Expectorants, excl. combinations with cough suppressants

R05CA - Expectorants

R05CA01 - Tyloxapol


5.4 Mechanism of Action

Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.


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13-Mar-2021
27-Dec-2024
KGS
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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Looking for 25301-02-4 / Tyloxapol API API manufacturers, exporters & distributors?

Tyloxapol API manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tyloxapol API API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tyloxapol API manufacturer or Tyloxapol API supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tyloxapol API manufacturer or Tyloxapol API supplier.

PharmaCompass also assists you with knowing the Tyloxapol API API Price utilized in the formulation of products. Tyloxapol API API Price is not always fixed or binding as the Tyloxapol API Price is obtained through a variety of data sources. The Tyloxapol API Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tyloxapol API

Synonyms

Tyloxapol, 25301-02-4, Tyloxypal, Triton wr-1339, Superinone, Alevaire

Cas Number

25301-02-4

About Tyloxapol API

Tyloxapol is a non-ionic detergent often used as a surfactant.

Tyloxapol API Manufacturers

A Tyloxapol API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tyloxapol API, including repackagers and relabelers. The FDA regulates Tyloxapol API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tyloxapol API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tyloxapol API manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tyloxapol API Suppliers

A Tyloxapol API supplier is an individual or a company that provides Tyloxapol API active pharmaceutical ingredient (API) or Tyloxapol API finished formulations upon request. The Tyloxapol API suppliers may include Tyloxapol API API manufacturers, exporters, distributors and traders.

click here to find a list of Tyloxapol API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tyloxapol API GMP

Tyloxapol API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tyloxapol API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tyloxapol API GMP manufacturer or Tyloxapol API GMP API supplier for your needs.

Tyloxapol API CoA

A Tyloxapol API CoA (Certificate of Analysis) is a formal document that attests to Tyloxapol API's compliance with Tyloxapol API specifications and serves as a tool for batch-level quality control.

Tyloxapol API CoA mostly includes findings from lab analyses of a specific batch. For each Tyloxapol API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tyloxapol API may be tested according to a variety of international standards, such as European Pharmacopoeia (Tyloxapol API EP), Tyloxapol API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tyloxapol API USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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