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Chemistry

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Also known as: 869886-67-9, Vrt752271, Bvd-523, Ulixertinib [inn], Ulixertinib (bvd-523), Bvd-erk
Molecular Formula
C21H22Cl2N4O2
Molecular Weight
433.3  g/mol
InChI Key
KSERXGMCDHOLSS-LJQANCHMSA-N
FDA UNII
16ZDH50O1U

Ulixertinib
Ulixertinib is an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, ulixertinib inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
1 2D Structure

Ulixertinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1H-pyrrole-2-carboxamide
2.1.2 InChI
InChI=1S/C21H22Cl2N4O2/c1-12(2)26-20-8-16(17(23)10-25-20)14-7-18(24-9-14)21(29)27-19(11-28)13-4-3-5-15(22)6-13/h3-10,12,19,24,28H,11H2,1-2H3,(H,25,26)(H,27,29)/t19-/m1/s1
2.1.3 InChI Key
KSERXGMCDHOLSS-LJQANCHMSA-N
2.1.4 Canonical SMILES
CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl
2.1.5 Isomeric SMILES
CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
16ZDH50O1U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bvd-523

2. Vrt752271

2.3.2 Depositor-Supplied Synonyms

1. 869886-67-9

2. Vrt752271

3. Bvd-523

4. Ulixertinib [inn]

5. Ulixertinib (bvd-523)

6. Bvd-erk

7. 16zdh50o1u

8. Chembl3590106

9. Ulixertinib (inn)

10. 869886-67-9 (free Base)

11. Vrt-752271

12. Ulixertinib (bvd-523, Vrt752271)

13. 1h-pyrrole-2-carboxamide, 4-(5-chloro-2-((1-methylethyl)amino)-4-pyridinyl)-n-((1s)-1-(3-chlorophenyl)-2-hydroxyethyl)-

14. N-[(1s)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1h-pyrrole-2-carboxamide

15. (s)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-n-(1-(3-chlorophenyl)-2-hydroxyethyl)-1h-pyrrole-2-carboxamide

16. (s)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-n-(1-(3-chlorophenyl)-2-hydroxyethyl)-1h-pyrrole-2-carboxamide.

17. 4-[5-chloranyl-2-(propan-2-ylamino)pyridin-4-yl]-~{n}-[(1~{s})-1-(3-chlorophenyl)-2-oxidanyl-ethyl]-1~{h}-pyrrole-2-carboxamide

18. Unii-16zdh50o1u

19. Ulixertinib (bvd-523,vrt752271)

20. 4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-n-((s)-1-(3-chlorophenyl)-2-hydroxyethyl)-1h-pyrrole-2-carboxamide

21. Bvd523 Hcl

22. Bvd-523 Hcl

23. Ulixertinib [who-dd]

24. Vrt752271 Hcl

25. Gtpl9210

26. Schembl14211742

27. Dtxsid601025683

28. Bcp04232

29. Ex-a1332

30. Bdbm50094465

31. Nsc797771

32. Nsc800959

33. S7854

34. Zinc34642570

35. Akos025396467

36. Ccg-269049

37. Db13930

38. Nsc-797771

39. Nsc-800959

40. Ncgc00378692-02

41. Ncgc00378692-05

42. Ncgc00378692-07

43. Ac-33165

44. As-56114

45. Hy-15816

46. Bcp0726000085

47. D11038

48. J-690368

49. Q27089081

50. 3,5-dichloro-2-hydroxy-n-(4-methoxy-3-biphenylyl)benzenesulfonamide

51. 4-[5-chloro-2-(isopropylamino)-4-pyridinyl]-n-[(1s)-1-(3-chlorophenyl)-2-hydroxyethyl]-1h-pyrrole-2-carboxamide

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 433.3 g/mol
Molecular Formula C21H22Cl2N4O2
XLogP34.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass432.1119813 g/mol
Monoisotopic Mass432.1119813 g/mol
Topological Polar Surface Area90 Ų
Heavy Atom Count29
Formal Charge0
Complexity539
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Ulixertinib Manufacturers

A Ulixertinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ulixertinib, including repackagers and relabelers. The FDA regulates Ulixertinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ulixertinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ulixertinib Suppliers

A Ulixertinib supplier is an individual or a company that provides Ulixertinib active pharmaceutical ingredient (API) or Ulixertinib finished formulations upon request. The Ulixertinib suppliers may include Ulixertinib API manufacturers, exporters, distributors and traders.

Ulixertinib GMP

Ulixertinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ulixertinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ulixertinib GMP manufacturer or Ulixertinib GMP API supplier for your needs.

Ulixertinib CoA

A Ulixertinib CoA (Certificate of Analysis) is a formal document that attests to Ulixertinib's compliance with Ulixertinib specifications and serves as a tool for batch-level quality control.

Ulixertinib CoA mostly includes findings from lab analyses of a specific batch. For each Ulixertinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ulixertinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Ulixertinib EP), Ulixertinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ulixertinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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