EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

23 Drugs in Development

23 Drugs in Development

DIGITAL CONTENT

16 NEWS #PharmaBuzz

media
16 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

23DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Ory-2001, 1357362-02-7, Vafidemstat [inn], Lz82jlt4up, 1,3,4-oxadiazole-2-methanamine, 5-amino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-, 5-((((1r,2s)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine

Molecular Formula

C₁₉H₂₀N₄O₂

Molecular Weight

336.4 g/mol

InChI Key

XBBRLCXCBCZIOI-DLBZAZTESA-N

FDA UNII

LZ82JLT4UP

Vafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease).

1 2D Structure

Vafidemstat

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine

2.1.2 InChI

InChI=1S/C19H20N4O2/c20-19-23-22-18(25-19)11-21-17-10-16(17)14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16-17,21H,10-12H2,(H2,20,23)/t16-,17+/m0/s1

2.1.3 InChI Key

XBBRLCXCBCZIOI-DLBZAZTESA-N

2.1.4 Canonical SMILES

C1C(C1NCC2=NN=C(O2)N)C3=CC=C(C=C3)OCC4=CC=CC=C4

2.1.5 Isomeric SMILES

C1[C@H]([C@@H]1NCC2=NN=C(O2)N)C3=CC=C(C=C3)OCC4=CC=CC=C4

2.2 Other Identifiers

2.2.1 UNII

LZ82JLT4UP

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (1r,2s)-2-(4-(benzyloxy)phenyl)-n-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine

2. 1,3,4-oxadiazole-2-methanamine, 4,5-dihydro-5-imino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

3. Ory-2001

2.3.2 Depositor-Supplied Synonyms

1. Ory-2001

2. 1357362-02-7

3. Vafidemstat [inn]

4. Lz82jlt4up

5. 1,3,4-oxadiazole-2-methanamine, 5-amino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

6. 5-((((1r,2s)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine

7. 5-[[[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine

8. Unii-lz82jlt4up

9. Schembl528204

10. Chembl4802155

11. Bcp29383

12. Hy-112623

13. Cs-0058593

14. Ory 2001; Ory-2001; Ory2001

15. A930244

16. 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine

17. (1r,2s)-2-(4-(benzyloxy)phenyl)-n-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine

18. 1,3,4-oxadiazole-2-methanamine, 4,5-dihydro-5-imino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

2.4 Create Date

2012-11-30

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₀N₄O₂
Molecular Weight	336.4 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	336.15862589 g/mol
Monoisotopic Mass	336.15862589 g/mol
Topological Polar Surface Area	86.2 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	410
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Mechanism of Action

Vafidemstat is a small molecule irreversible inhibitor of histone demethylase LSD1 and also a dual inhibitor of LSD1/MAO-B.

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

ABOUT THIS PAGE

Find Vafidemstat manufacturers, exporters & distributors on PharmaCompass

Vafidemstat

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

DEVELOPMENTS

23 Drugs in Development

DIGITAL CONTENT

16 NEWS #PharmaBuzz

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

23DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

What are you looking for?