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Chemistry

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Also known as: Ory-2001, 1357362-02-7, Vafidemstat [inn], Lz82jlt4up, 1,3,4-oxadiazole-2-methanamine, 5-amino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-, 5-((((1r,2s)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine
Molecular Formula
C19H20N4O2
Molecular Weight
336.4  g/mol
InChI Key
XBBRLCXCBCZIOI-DLBZAZTESA-N
FDA UNII
LZ82JLT4UP

Vafidemstat
Vafidemstat is under investigation in clinical trial NCT03867253 (Testing the Safety and Preliminary Efficacy of the New Drug ORY-2001 in Mild to Moderate Alzheimer's Disease).
1 2D Structure

Vafidemstat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[[(1R,2S)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine
2.1.2 InChI
InChI=1S/C19H20N4O2/c20-19-23-22-18(25-19)11-21-17-10-16(17)14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16-17,21H,10-12H2,(H2,20,23)/t16-,17+/m0/s1
2.1.3 InChI Key
XBBRLCXCBCZIOI-DLBZAZTESA-N
2.1.4 Canonical SMILES
C1C(C1NCC2=NN=C(O2)N)C3=CC=C(C=C3)OCC4=CC=CC=C4
2.1.5 Isomeric SMILES
C1[C@H]([C@@H]1NCC2=NN=C(O2)N)C3=CC=C(C=C3)OCC4=CC=CC=C4
2.2 Other Identifiers
2.2.1 UNII
LZ82JLT4UP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (1r,2s)-2-(4-(benzyloxy)phenyl)-n-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine

2. 1,3,4-oxadiazole-2-methanamine, 4,5-dihydro-5-imino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

3. Ory-2001

2.3.2 Depositor-Supplied Synonyms

1. Ory-2001

2. 1357362-02-7

3. Vafidemstat [inn]

4. Lz82jlt4up

5. 1,3,4-oxadiazole-2-methanamine, 5-amino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

6. 5-((((1r,2s)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine

7. 5-[[[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]methyl]-1,3,4-oxadiazol-2-amine

8. Unii-lz82jlt4up

9. Schembl528204

10. Chembl4802155

11. Bcp29383

12. Hy-112623

13. Cs-0058593

14. Ory 2001; Ory-2001; Ory2001

15. A930244

16. 5-(((trans)-2-(4-(benzyloxy)phenyl)cyclopropylamino)methyl)-1,3,4-oxadiazol-2-amine

17. (1r,2s)-2-(4-(benzyloxy)phenyl)-n-((5-imino-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)cyclopropanamine

18. 1,3,4-oxadiazole-2-methanamine, 4,5-dihydro-5-imino-n-((1r,2s)-2-(4-(phenylmethoxy)phenyl)cyclopropyl)-

2.4 Create Date
2012-11-30
3 Chemical and Physical Properties
Molecular Weight 336.4 g/mol
Molecular Formula C19H20N4O2
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass336.15862589 g/mol
Monoisotopic Mass336.15862589 g/mol
Topological Polar Surface Area86.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Vafidemstat is a small molecule irreversible inhibitor of histone demethylase LSD1 and also a dual inhibitor of LSD1/MAO-B.


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ABOUT THIS PAGE

Vafidemstat Manufacturers

A Vafidemstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vafidemstat, including repackagers and relabelers. The FDA regulates Vafidemstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vafidemstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vafidemstat Suppliers

A Vafidemstat supplier is an individual or a company that provides Vafidemstat active pharmaceutical ingredient (API) or Vafidemstat finished formulations upon request. The Vafidemstat suppliers may include Vafidemstat API manufacturers, exporters, distributors and traders.

Vafidemstat GMP

Vafidemstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vafidemstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vafidemstat GMP manufacturer or Vafidemstat GMP API supplier for your needs.

Vafidemstat CoA

A Vafidemstat CoA (Certificate of Analysis) is a formal document that attests to Vafidemstat's compliance with Vafidemstat specifications and serves as a tool for batch-level quality control.

Vafidemstat CoA mostly includes findings from lab analyses of a specific batch. For each Vafidemstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vafidemstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Vafidemstat EP), Vafidemstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vafidemstat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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