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Chemistry

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Also known as:
Molecular Formula
C23H33ClN6O4S
Molecular Weight
525.1  g/mol
InChI Key
XCMULUAPJXCOHI-UHFFFAOYSA-N

Vardenafil Hydrochloride
1 2D Structure

Vardenafil Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;hydrochloride
2.1.2 InChI
InChI=1S/C23H32N6O4S.ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H
2.1.3 InChI Key
XCMULUAPJXCOHI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
2.1.5 Isomeric SMILES
CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
2.2 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 525.1 g/mol
Molecular Formula C23H33ClN6O4S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass524.1972524 g/mol
Monoisotopic Mass524.1972524 g/mol
Topological Polar Surface Area118 A^2
Heavy Atom Count35
Formal Charge0
Complexity854
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameVardenafil hydrochloride
Drug LabelLEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
Active IngredientVardenafil hydrochloride
Dosage FormTablet
RouteOral
Strength2.5mg; 5mg; 10mg; 20mg
Market StatusPrescription
CompanyTeva Pharms

2 of 2  
Drug NameVardenafil hydrochloride
Drug LabelLEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
Active IngredientVardenafil hydrochloride
Dosage FormTablet
RouteOral
Strength2.5mg; 5mg; 10mg; 20mg
Market StatusPrescription
CompanyTeva Pharms

API Reference Price

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PLC,","customerCountry":"BANGLADESH","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"925","totalValueFC":"18296.6","currency":"USD","unitRateINR":76255,"date":"08-May-2024","totalValueINR":"1525100","totalValueInUsd":"18296.6","indian_port":"Hyderabad Air","hs_no":"29359090","bill_no":"9713689","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"425\/3 RT D NO 7-1-621\/328,, HYDERABAD.AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715970600,"product":"VARDENAFIL HYDROCHLORIDE TRIHYDRATE","address":"425\/3 RT D NO 7-1-621\/328,","city":"HYDERABAD.AP","supplier":"RAKSHIT PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"EXP TRANS GMBH","customerCountry":"LEBANON","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"795","totalValueFC":"7882.8","currency":"USD","unitRateINR":65706.75,"date":"18-May-2024","totalValueINR":"657067.5","totalValueInUsd":"7882.8","indian_port":"Hyderabad Air","hs_no":"29359090","bill_no":"9972032","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"425\/3 RT D NO 7-1-621\/328,, HYDERABAD.AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719253800,"product":"OTHER ORGANIC CHEMICALS VARDENAFIL HYDROCHLORIDE TRIHYDRATE (IHS)","address":"113, J.K.CHAMBERS,","city":"NEW MUMBAI ,MAHARASHTRA","supplier":"ULTRATECH INDIA LTD.,","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"SILIBACK PHARMA","customerCountry":"EGYPT","quantity":"35.00","actualQuantity":"35","unit":"KGS","unitRateFc":"1560","totalValueFC":"54011.6","currency":"USD","unitRateINR":128824.57142857143,"date":"25-Jun-2024","totalValueINR":"4508860","totalValueInUsd":"54011.6","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"1925521","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"113, J.K.CHAMBERS,, NEW MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721413800,"product":"VARDENAFIL HYDROCHLORIDE TRIHYDRATE,USP","address":"PLOT NO.19-III, ROAD NO.71, OPP.","city":"JUBILEE HILLS, HYDERABAD. 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AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722191400,"product":"OTHER ORGANIC CHEMICALS - VARDENAFIL HYDROCHLORIDE TRIHYDRATE EP","address":"113, J.K.CHAMBERS,","city":"NEW MUMBAI ,MAHARASHTRA","supplier":"ULTRATECH INDIA LTD.,","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"DUONG PHARMACEUTICAL","customerCountry":"VIETNAM","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1900","totalValueFC":"1823.4","currency":"USD","unitRateINR":152420,"date":"29-Jul-2024","totalValueINR":"152420","totalValueInUsd":"1823.4","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"2775912","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"113, J.K.CHAMBERS,, NEW MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723401000,"product":"DRUGS AND PHARMACEUTICALS HARMLESSMEDICINES VARDENAFIL HYDROCHLORIDE TRIHYDRATE (PH.EUR + IN-HOUSE)CAS 33080","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"MACLEODS PHARMACEUTICALS LTD","supplierCountry":"INDIA","foreign_port":"JEDDAH","customer":"JAMJOOM PHARMACEUTICALS COMPANY,,","customerCountry":"SAUDI ARABIA","quantity":"18.86","actualQuantity":"18.86","unit":"KGS","unitRateFc":"3100","totalValueFC":"57669","currency":"USD","unitRateINR":256479.00848356308,"date":"12-Aug-2024","totalValueINR":"4837194.1","totalValueInUsd":"57669","indian_port":"Bombay Air","hs_no":"29331999","bill_no":"3154878","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"304,ATLANTA ARCADE,, MUMBAI MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723746600,"product":"VARDENAFIL HYDROCHLORIDE TRIHYDRATE PH.EUR","address":"PLOT NO.19-III, ROAD NO.71, OPP.","city":"JUBILEE HILLS, HYDERABAD. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1640543400,"product":"CHEMICAL : VARDENAFIL HYDROCHLORIDE TRIHYDRATE","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,, S.G. HIGHWAY, THALTEJ","city":"AHMEDABAD,GUJARAT","supplier":"POLPHARMA","supplierCountry":"POLAND","foreign_port":"WARSAW","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"5940","totalValueFC":"20719.8","currency":"EUR","unitRateINR":"520938","date":"27-Dec-2021","totalValueINR":"1562814","totalValueInUsd":"20719.8","indian_port":"AHMEDABAD AIR","hs_no":"29359090","bill_no":"6851577","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"WARSAW","supplierAddress":"","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,, S.G. 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22-Feb-2021
17-Aug-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Europe

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01

Bayer Pharma AG

Germany
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Bayer Pharma AG

Germany
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vardenafilhydrokloridtrihydrat

Brand Name : Levitra

Dosage Form : FILM COATED PILL

Dosage Strength : 5 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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02

Bayer Pharma AG

Germany
Formnext Forum
Not Confirmed
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Bayer Pharma AG

Germany
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Formnext Forum
Not Confirmed

vardenafilhydrokloridtrihydrat

Brand Name : Levitra

Dosage Form : FILM COATED PILL

Dosage Strength : 20 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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03

Bayer Pharma AG

Germany
Formnext Forum
Not Confirmed
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Bayer Pharma AG

Germany
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Formnext Forum
Not Confirmed

vardenafilhydrokloridtrihydrat

Brand Name : Vivanza

Dosage Form : FILMDRAGERAD TABLETT

Dosage Strength : 20 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

BAYER SpA

Germany
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Not Confirmed
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BAYER SpA

Germany
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Not Confirmed

Vardenafil

Brand Name : Levitra

Dosage Form :

Dosage Strength : 12 Cpr Riv 10 Mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

Bayer Pharma AG

Germany
Formnext Forum
Not Confirmed
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Bayer Pharma AG

Germany
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Formnext Forum
Not Confirmed

Vardenafil

Brand Name : Levitra

Dosage Form : Antic-calc Tablet, Film Coated

Dosage Strength : 10 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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06

Bayer Pharma AG

Germany
Formnext Forum
Not Confirmed
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Bayer Pharma AG

Germany
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Vardenafil

Brand Name : Levitra

Dosage Form : Antic-calc Tablet, Film Coated

Dosage Strength : 5 mg

Packaging : Blister

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Application Number :

Regulatory Info :

Registration Country : Norway

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GLAXOSMITHKLINE SpA

United Kingdom
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GLAXOSMITHKLINE SpA

United Kingdom
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Vardenafil

Brand Name : Vivanza

Dosage Form :

Dosage Strength : 4 Cpr Riv 10 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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GLAXOSMITHKLINE SpA

United Kingdom
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GLAXOSMITHKLINE SpA

United Kingdom
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Vardenafil

Brand Name : Vivanza

Dosage Form :

Dosage Strength : 4 Cpr Riv 20 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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09

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Vardenafil

Brand Name :

Dosage Form : IR TABLET

Dosage Strength : 10MG

Packaging :

Approval Date :

Application Number : 21400

Regulatory Info : Generic US CTD

Registration Country : United Kingdom

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10

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Vardenafil

Brand Name : VARDENAFIL TEVA ITALY

Dosage Form : Film-Coated Tablets

Dosage Strength : 20 mg

Packaging : 12 UNITS 20 MG - ORAL USE

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 200179

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DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21400

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DOSAGE - TABLET;ORAL - EQ 2.5MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21400

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DOSAGE - TABLET;ORAL - EQ 20MG BASE **Federal...DOSAGE - TABLET;ORAL - EQ 20MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21400

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DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal ...DOSAGE - TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21400

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