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Chemistry

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Also known as: 1146629-86-8, Arry-543, Varlitinib tosilate, Varlitinib tosylate [usan], Arry-543 ditosilate, Arry-334543 ditosilate
Molecular Formula
C36H35ClN6O8S3
Molecular Weight
811.4  g/mol
InChI Key
QSUPQMGDXOHVLK-FFXKMJQXSA-N
FDA UNII
V4M8FWS152

Varlitinib Tosylate
Varlitinib Tosylate is the tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.
1 2D Structure

Varlitinib Tosylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine;4-methylbenzenesulfonic acid
2.1.2 InChI
InChI=1S/C22H19ClN6O2S.2C7H8O3S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28);2*2-5H,1H3,(H,8,9,10)/t13-;;/m1../s1
2.1.3 InChI Key
QSUPQMGDXOHVLK-FFXKMJQXSA-N
2.1.4 Canonical SMILES
CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl.CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O
2.1.5 Isomeric SMILES
C[C@@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl.CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
V4M8FWS152
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1146629-86-8

2. Arry-543

3. Varlitinib Tosilate

4. Varlitinib Tosylate [usan]

5. Arry-543 Ditosilate

6. Arry-334543 Ditosilate

7. Ar00334543 Ditosilate

8. V4m8fws152

9. Ar00334543

10. Varlitinib Tosylate (usan)

11. Unii-v4m8fws152

12. Arry 543

13. Varlitinib Ditosylate

14. Ar 00334543

15. Arry-543 Ditosylate

16. Schembl572691

17. Chembl2105679

18. Arry-334543 Ditosylate

19. Ar00334543 Ditosylate

20. Ex-a4491

21. Mfcd20275100

22. Varlitinib Tosylate [who-dd]

23. N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-n6-[(4r)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine Bis(4-methylbenzenesulfonate)

24. D09690

25. Ar00334543 Arry-334543 Arry-543

26. Q27291527

27. 4,6-quinazolinediamine, N4-(3-chloro-4-(2-thiazolylmethoxy)phenyl)-n6-((4r)-4,5-dihydro-4-methyl-2-oxazolyl)-, 4-methylbenzenesulfonate (1:2)

28. 4-n-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-n-((4r)-4-methyl-4,5-dihydrooxazol-2- Yl)quinazoline-4,6-diamine Bis(4-methylbenzenesulfonate)

2.4 Create Date
2009-10-12
3 Chemical and Physical Properties
Molecular Weight 811.4 g/mol
Molecular Formula C36H35ClN6O8S3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count9
Exact Mass810.1367033 g/mol
Monoisotopic Mass810.1367033 g/mol
Topological Polar Surface Area247 Ų
Heavy Atom Count54
Formal Charge0
Complexity866
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

ABOUT THIS PAGE

Looking for 1146629-86-8 / Varlitinib Tosylate API manufacturers, exporters & distributors?

Varlitinib Tosylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Varlitinib Tosylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Varlitinib Tosylate manufacturer or Varlitinib Tosylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Varlitinib Tosylate manufacturer or Varlitinib Tosylate supplier.

PharmaCompass also assists you with knowing the Varlitinib Tosylate API Price utilized in the formulation of products. Varlitinib Tosylate API Price is not always fixed or binding as the Varlitinib Tosylate Price is obtained through a variety of data sources. The Varlitinib Tosylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Varlitinib Tosylate

Synonyms

1146629-86-8, Arry-543, Varlitinib tosilate, Varlitinib tosylate [usan], Arry-543 ditosilate, Arry-334543 ditosilate

Cas Number

1146629-86-8

Unique Ingredient Identifier (UNII)

V4M8FWS152

About Varlitinib Tosylate

Varlitinib Tosylate is the tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.

Varlitinib Tosylate Manufacturers

A Varlitinib Tosylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Varlitinib Tosylate, including repackagers and relabelers. The FDA regulates Varlitinib Tosylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Varlitinib Tosylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Varlitinib Tosylate Suppliers

A Varlitinib Tosylate supplier is an individual or a company that provides Varlitinib Tosylate active pharmaceutical ingredient (API) or Varlitinib Tosylate finished formulations upon request. The Varlitinib Tosylate suppliers may include Varlitinib Tosylate API manufacturers, exporters, distributors and traders.

Varlitinib Tosylate GMP

Varlitinib Tosylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Varlitinib Tosylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Varlitinib Tosylate GMP manufacturer or Varlitinib Tosylate GMP API supplier for your needs.

Varlitinib Tosylate CoA

A Varlitinib Tosylate CoA (Certificate of Analysis) is a formal document that attests to Varlitinib Tosylate's compliance with Varlitinib Tosylate specifications and serves as a tool for batch-level quality control.

Varlitinib Tosylate CoA mostly includes findings from lab analyses of a specific batch. For each Varlitinib Tosylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Varlitinib Tosylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Varlitinib Tosylate EP), Varlitinib Tosylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Varlitinib Tosylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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