Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

DIGITAL CONTENT

13 NEWS #PharmaBuzz

media
13 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

8DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Vebreltinib, 1440964-89-5, Plb-1001, Apl-101, Vebreltinib [usan], Cbi-3103

Molecular Formula

C₂₀H₁₅F₃N₈

Molecular Weight

424.4 g/mol

InChI Key

QHXLXUIZUCJRKV-UHFFFAOYSA-N

FDA UNII

2WZP8A9VFN

Vebreltinib is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) with potential antineoplastic activity. Upon administration, vebreltinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

1 2D Structure

Vebreltinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine

2.1.2 InChI

InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3

2.1.3 InChI Key

QHXLXUIZUCJRKV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C=C2C=C(C(=CC2=N1)F)C(C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C6CC6)(F)F

2.2 Other Identifiers

2.2.1 UNII

2WZP8A9VFN

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Vebreltinib

2. 1440964-89-5

3. Plb-1001

4. Apl-101

5. Vebreltinib [usan]

6. Cbi-3103

7. 2wzp8a9vfn

8. Cbt-101

9. 6-(1-cyclopropylpyrazol-4-yl)-3-[difluoro-(6-fluoro-2-methylindazol-5-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazine

10. 1,2,4-triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1h-pyrazol-4-yl)-3-(difluoro(6- Fluoro-2-methyl-2h-indazol-5-yl)methyl)-

11. 6-(1-cyclopropyl-1h-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2h-indazol-5- Yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine

12. Unii-2wzp8a9vfn

13. Vebreltinib [inn]

14. Bozitinib (plb-1001)

15. Vebreltinib [who-dd]

16. Chembl4650443

17. Schembl15594471

18. Gtpl11677

19. Plb1001

20. Bdbm107096

21. Ex-a5644

22. S6762

23. Who 11677

24. Hy-125017

25. Cs-0088607

26. Us9695175, 44

27. A937089

28. Plb-1001;t-101; Apl-101; Cbi-3103

29. 6-(1-cyclopropyl-1h-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2h-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine

2.4 Create Date

2013-12-23

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₁₅F₃N₈
Molecular Weight	424.4 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	424.13717700 g/mol
Monoisotopic Mass	424.13717700 g/mol
Topological Polar Surface Area	78.7 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	681
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1