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Chemistry

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Also known as: 1093130-72-3, Inxn-1001, Rg-115932, Asu841tv0x, N'-(3,5-dimethylbenzoyl)-n'-[(3r)-2,2-dimethylhexan-3-yl]-2-ethyl-3-methoxybenzohydrazide, Benzoic acid, 2-ethyl-3-methoxy-, 2-(3,5-dimethylbenzoyl)-2-((1r)-1-(1,1-dimethylethyl)butyl)hydrazide
Molecular Formula
C27H38N2O3
Molecular Weight
438.6  g/mol
InChI Key
LZWZPGLVHLSWQX-XMMPIXPASA-N
FDA UNII
ASU841TV0X

Veledimex
Veledimex is an orally bioavailable, small molecule diacylhydrazine-based activator ligand, that can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Upon administration of veledimex, this agent specifically binds to the EcR located on the separately administered RTS, which includes two fusions proteins: Gal4-EcR, which contains a modified ecdysone receptor (EcR) fused with the DNA binding domain of the yeast Gal4 transcription factor, and VP16-RXR, which contains a chimeric retinoid X receptor (RXR) fused with the transcription activation domain of the viral protein VP16 of herpes simplex virus type 1 (HSV1). The fusion proteins form inactive, unstable and unproductive heterodimers in the absence of veledimex. In the presence of veledimex, the protein heterodimer changes to a stable conformation, forming an active transcription factor complex, which can bind to the inducible promoter, thereby allowing the induction of controlled transcription of the target gene.
1 2D Structure

Veledimex

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N'-(3,5-dimethylbenzoyl)-N'-[(3R)-2,2-dimethylhexan-3-yl]-2-ethyl-3-methoxybenzohydrazide
2.1.2 InChI
InChI=1S/C27H38N2O3/c1-9-12-24(27(5,6)7)29(26(31)20-16-18(3)15-19(4)17-20)28-25(30)22-13-11-14-23(32-8)21(22)10-2/h11,13-17,24H,9-10,12H2,1-8H3,(H,28,30)/t24-/m1/s1
2.1.3 InChI Key
LZWZPGLVHLSWQX-XMMPIXPASA-N
2.1.4 Canonical SMILES
CCCC(C(C)(C)C)N(C(=O)C1=CC(=CC(=C1)C)C)NC(=O)C2=C(C(=CC=C2)OC)CC
2.1.5 Isomeric SMILES
CCC[C@H](C(C)(C)C)N(C(=O)C1=CC(=CC(=C1)C)C)NC(=O)C2=C(C(=CC=C2)OC)CC
2.2 Other Identifiers
2.2.1 UNII
ASU841TV0X
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1093130-72-3

2. Inxn-1001

3. Rg-115932

4. Asu841tv0x

5. N'-(3,5-dimethylbenzoyl)-n'-[(3r)-2,2-dimethylhexan-3-yl]-2-ethyl-3-methoxybenzohydrazide

6. Benzoic Acid, 2-ethyl-3-methoxy-, 2-(3,5-dimethylbenzoyl)-2-((1r)-1-(1,1-dimethylethyl)butyl)hydrazide

7. Veledimex [usan:inn]

8. Unii-asu841tv0x

9. Veledimex [inn]

10. Veledimex (usan/inn)

11. Veledimex [usan]

12. Veledimex [who-dd]

13. Schembl2582702

14. Chembl3039523

15. Dtxsid00148875

16. Db12170

17. As-84226

18. Hy-16785

19. D10678

20. Q27274109

21. (r)-3,5-dimethyl-benzoic Acid N-(1-tert-butyl-butyl)-n'-(2-ethyl-3-methoxy-benzoyl)-hydrazide

2.4 Create Date
2012-08-19
3 Chemical and Physical Properties
Molecular Weight 438.6 g/mol
Molecular Formula C27H38N2O3
XLogP37.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass438.28824308 g/mol
Monoisotopic Mass438.28824308 g/mol
Topological Polar Surface Area58.6 Ų
Heavy Atom Count32
Formal Charge0
Complexity605
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Veledimex Manufacturers

A Veledimex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Veledimex, including repackagers and relabelers. The FDA regulates Veledimex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Veledimex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Veledimex Suppliers

A Veledimex supplier is an individual or a company that provides Veledimex active pharmaceutical ingredient (API) or Veledimex finished formulations upon request. The Veledimex suppliers may include Veledimex API manufacturers, exporters, distributors and traders.

Veledimex GMP

Veledimex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Veledimex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Veledimex GMP manufacturer or Veledimex GMP API supplier for your needs.

Veledimex CoA

A Veledimex CoA (Certificate of Analysis) is a formal document that attests to Veledimex's compliance with Veledimex specifications and serves as a tool for batch-level quality control.

Veledimex CoA mostly includes findings from lab analyses of a specific batch. For each Veledimex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Veledimex may be tested according to a variety of international standards, such as European Pharmacopoeia (Veledimex EP), Veledimex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Veledimex USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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