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Synopsis

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Chemistry

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Also known as: 912444-00-9, Abt-888, Abt 888, Abt-888 (veliparib), Veliparib free base, Abt888
Molecular Formula
C13H16N4O
Molecular Weight
244.29  g/mol
InChI Key
JNAHVYVRKWKWKQ-CYBMUJFWSA-N
FDA UNII
01O4K0631N

Veliparib
Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.
1 2D Structure

Veliparib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
2.1.2 InChI
InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
2.1.3 InChI Key
JNAHVYVRKWKWKQ-CYBMUJFWSA-N
2.1.4 Canonical SMILES
CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
2.1.5 Isomeric SMILES
C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
01O4K0631N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

2. 2-(2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

3. Abt 888

4. Abt-888

5. Abt888

2.3.2 Depositor-Supplied Synonyms

1. 912444-00-9

2. Abt-888

3. Abt 888

4. Abt-888 (veliparib)

5. Veliparib Free Base

6. Abt888

7. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benzo[d]imidazole-4-carboxamide

8. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide

9. 2-[(2r)-2-methyl-2-pyrrolidinyl]-1h-benzimidazole-7-carboxamide

10. Chebi:62880

11. 2-[(r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide

12. Parp-1 Inhibitor Abt-888

13. 912444-00-9 (free Base)

14. 01o4k0631n

15. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benimidazole-4-

16. (2r)-2-(7-carbamoyl-1h-benzimidazol-2-yl)-2-methylpyrrolidinium

17. 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

18. Veliparib (abt-888)

19. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benimidazole-4-carboxamide (veliparib)

20. 2-((2r)-2-methyl-2-pyrrolidinyl)-1h-benzimidazole-7-carboxamide

21. 2-((2r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide

22. Nsc-737664

23. Veliparib [usan:inn]

24. Mfcd16661059

25. Unii-01o4k0631n

26. 78p

27. Veliparib [inn]

28. Veliparib [jan]

29. Veliparib [usan]

30. Abt888 (free Base)

31. (r)-2-(2-methylpyrrolidin-2-yl)-1h-benzo[d]imidazole-7-carboxamide

32. Veliparib [who-dd]

33. Benzimidazole Carboxamide, 3a

34. Mls006010184

35. Veliparib (jan/usan/inn)

36. Schembl422318

37. Chembl506871

38. Gtpl7417

39. Bdbm27135

40. Abt-695

41. Dtxsid90238456

42. Ex-a001

43. Bdbm209932

44. Veliparib (abt-888 Hydrochloride)

45. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-1,3-benzodiazole-4-carboxamide

46. Nsc737664

47. Nsc752840

48. S1004

49. Zinc84610155

50. Akos015951440

51. Akos017343746

52. Ccg-264771

53. Cs-0076

54. Db07232

55. Ex-7209

56. Nsc 737664

57. Nsc-752840

58. Sb16480

59. Ncgc00250404-01

60. Ncgc00250404-15

61. Ac-23330

62. As-19397

63. Hy-10129

64. Smr004701290

65. Abt-888 (veliparib, Nsc 737664)

66. A24888

67. D09692

68. A 861695

69. A-861695

70. J-505211

71. Q7919041

72. Brd-k87142802-001-02-7

73. 1h-benzimidazole-4-carboxamide, 2-((2r)-2-methyl-2-pyrrolidinyl)-

74. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benimidazole-4-carboxamide

75. 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-7-carboxamide

76. 2-[(r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide;

77. 1h-benzimidazole-7-carboxamide, 2-((2r)-2-methyl-2-pyrrolidinyl)-

2.4 Create Date
2006-12-11
3 Chemical and Physical Properties
Molecular Weight 244.29 g/mol
Molecular Formula C13H16N4O
XLogP30.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass244.13241115 g/mol
Monoisotopic Mass244.13241115 g/mol
Topological Polar Surface Area83.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity348
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of fallopian tube cancer , Treatment of ovarian cancer , Treatment of peritoneal carcinoma


Treatment of lung carcinoma (small cell and non-small cell carcinoma)


Treatment of breast cancer


Treatment of high-grade glioma


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Poly(ADP-ribose) Polymerase Inhibitors

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. (See all compounds classified as Poly(ADP-ribose) Polymerase Inhibitors.)


5.2 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01X - Other antineoplastic agents

L01XK - Poly (adp-ribose) polymerase (parp) inhibitors

L01XK05 - Veliparib


ABOUT THIS PAGE

Veliparib Manufacturers

A Veliparib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Veliparib, including repackagers and relabelers. The FDA regulates Veliparib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Veliparib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Veliparib Suppliers

A Veliparib supplier is an individual or a company that provides Veliparib active pharmaceutical ingredient (API) or Veliparib finished formulations upon request. The Veliparib suppliers may include Veliparib API manufacturers, exporters, distributors and traders.

Veliparib GMP

Veliparib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Veliparib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Veliparib GMP manufacturer or Veliparib GMP API supplier for your needs.

Veliparib CoA

A Veliparib CoA (Certificate of Analysis) is a formal document that attests to Veliparib's compliance with Veliparib specifications and serves as a tool for batch-level quality control.

Veliparib CoA mostly includes findings from lab analyses of a specific batch. For each Veliparib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Veliparib may be tested according to a variety of international standards, such as European Pharmacopoeia (Veliparib EP), Veliparib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Veliparib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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