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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS

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JDMF

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KDMF

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NDC API

NDC API

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VMF

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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DRUG PRODUCT COMPOSITIONS

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PATENTS & EXCLUSIVITIES

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US Patents

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API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

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Chemistry

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Also known as: Ibiglustat, 1401090-53-6, Genz-682452, Sar402671, Gz/sar402671, Genz-682452-aa
Molecular Formula
C20H24FN3O2S
Molecular Weight
389.5  g/mol
InChI Key
YFHRCLAKZBDRHN-MRXNPFEDSA-N
FDA UNII
BLP1XA3FZA

Venglustat
Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).
1 2D Structure

Venglustat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3S)-1-azabicyclo[2.2.2]octan-3-yl] N-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate
2.1.2 InChI
InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
2.1.3 InChI Key
YFHRCLAKZBDRHN-MRXNPFEDSA-N
2.1.4 Canonical SMILES
CC(C)(C1=CSC(=N1)C2=CC=C(C=C2)F)NC(=O)OC3CN4CCC3CC4
2.1.5 Isomeric SMILES
CC(C)(C1=CSC(=N1)C2=CC=C(C=C2)F)NC(=O)O[C@@H]3CN4CCC3CC4
2.2 Other Identifiers
2.2.1 UNII
BLP1XA3FZA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Genz-682452

2. Gz-sar402671

3. Ibiglustat

2.3.2 Depositor-Supplied Synonyms

1. Ibiglustat

2. 1401090-53-6

3. Genz-682452

4. Sar402671

5. Gz/sar402671

6. Genz-682452-aa

7. Venglustat [usan]

8. Gz402671

9. Blp1xa3fza

10. (s)-quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

11. Sar-402671

12. [(3s)-1-azabicyclo[2.2.2]octan-3-yl] N-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate

13. Gz-402671

14. (3s)-1-azabicyclo(2.2.2)octan-3-yl N-(2-(2-(4-fluorophenyl)-1,3-thiazol-4-yl)propan-2-yl)carbamate

15. Carbamic Acid, N-(1-(2-(4-fluorophenyl)-4-thiazolyl)-1-methylethyl)-, (3s)-1-azabicyclo(2.2.2)oct-3-yl Ester

16. Carbamic Acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3s)-1-azabicyclo[2.2.2]oct-3-yl Ester

17. Ibiglustat [inn]

18. Unii-blp1xa3fza

19. Venglustat [inn]

20. Venglustat (usan/inn)

21. Ibiglustat(genz-682452

22. Venglustat [who-dd]

23. Chembl4297611

24. Schembl12615329

25. Gtpl11550

26. Gz/sar-402671

27. Amy19519

28. Bgc09053

29. Ex-a1870

30. Mfcd28502073

31. Who 10063

32. Akos027337125

33. Zinc202143443

34. Cs-6512

35. Db14966

36. Ac-35551

37. As-52367

38. Hy-16743

39. D11633

40. P14969

41. Q27274745

42. (s)-quinuclidin-3-yl 2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-ylcarbamate

43. (s)-quinuclidin-3-yl(2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

2.4 Create Date
2012-10-08
3 Chemical and Physical Properties
Molecular Weight 389.5 g/mol
Molecular Formula C20H24FN3O2S
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass389.15732635 g/mol
Monoisotopic Mass389.15732635 g/mol
Topological Polar Surface Area82.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of polycystic kidney disease


Treatment of Parkinson's disease


Treatment of autosomal dominant polycystic kidney disease


Treatment of galactosialidosis, Treatment of GM1 gangliosidosis, Treatment of GM2 gangliosidosis, Treatment of sialidosis


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


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ABOUT THIS PAGE

Looking for 1401090-53-6 / Venglustat API manufacturers, exporters & distributors?

Venglustat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Venglustat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Venglustat manufacturer or Venglustat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Venglustat manufacturer or Venglustat supplier.

PharmaCompass also assists you with knowing the Venglustat API Price utilized in the formulation of products. Venglustat API Price is not always fixed or binding as the Venglustat Price is obtained through a variety of data sources. The Venglustat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Venglustat

Synonyms

Ibiglustat, 1401090-53-6, Genz-682452, Sar402671, Gz/sar402671, Genz-682452-aa

Cas Number

1401090-53-6

Unique Ingredient Identifier (UNII)

BLP1XA3FZA

About Venglustat

Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).

Venglustat Manufacturers

A Venglustat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Venglustat, including repackagers and relabelers. The FDA regulates Venglustat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Venglustat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Venglustat Suppliers

A Venglustat supplier is an individual or a company that provides Venglustat active pharmaceutical ingredient (API) or Venglustat finished formulations upon request. The Venglustat suppliers may include Venglustat API manufacturers, exporters, distributors and traders.

Venglustat GMP

Venglustat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Venglustat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Venglustat GMP manufacturer or Venglustat GMP API supplier for your needs.

Venglustat CoA

A Venglustat CoA (Certificate of Analysis) is a formal document that attests to Venglustat's compliance with Venglustat specifications and serves as a tool for batch-level quality control.

Venglustat CoA mostly includes findings from lab analyses of a specific batch. For each Venglustat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Venglustat may be tested according to a variety of international standards, such as European Pharmacopoeia (Venglustat EP), Venglustat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Venglustat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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