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Venlafaxine HCl

Renejix: CDMO with expertise in small molecule oral dosage, delivery tech, and multi-modality manufacturing.

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ACTIVE PHARMA INGREDIENTS

86 API Suppliers, 43 USDMF, 45 CEP/COS, 3 JDMF, 24 EU WC, 6 KDMF, 20 NDC API, 29 Listed Suppliers, $ API Reference Price

86 API Suppliers
43 USDMF
45 CEP/COS
3 JDMF
24 EU WC
6 KDMF
20 NDC API
29 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

456 FDF Dossiers, 177 FDA Orange Book, 199 Europe, 48 Canada, 7 South Africa, 25 Listed Dossiers

456 FDF Dossiers
177 FDA Orange Book
199 Europe
48 Canada
7 South Africa
25 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE, TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

drugProductComposition
CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE
CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE
CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE
TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

RELATED EXCIPIENT COMPANIES

1 Minakem, 2 Evonik, 3 Rochem International Inc, 19 SPI Pharma, 2 Seqens, 10 DKSH, 3 Jai Radhe Sales, 1 Pharm-RX Chemical, 10 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 14 Gangwal Healthcare, 10 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 7 Actylis, 1 Aeon Procare, 3 Alcedo Pharmachem, 11 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 39 BASF, 2 Clariant, 16 Corel Pharma Chem, 7 DFE Pharma, 2 Finar, 13 Gangwal Chemicals, 11 Ideal Cures Pvt Ltd, 5 Ingredion Pharma Solutions, 39 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 15 Microlex e.U, 1 Nanjing Bold Chemical, 1 NEWEDGE Overseas, 2 Nomisma Healthcare, 4 Novo Excipients, 5 Pharmatrans-Sanaq, 8 Pluviaendo, 5 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 25 Roquette, 17 Seppic, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 4 Ulanqab Kema New Material, 3 Valens Pharmachem, 4 Vasa Pharmachem, 2 Vertellus

relatedExcipients
1 Minakem
2 Evonik
3 Rochem International Inc
19 SPI Pharma
2 Seqens
10 DKSH
3 Jai Radhe Sales
1 Pharm-RX Chemical
10 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
14 Gangwal Healthcare
10 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
7 Actylis
1 Aeon Procare
3 Alcedo Pharmachem
11 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
39 BASF
2 Clariant
16 Corel Pharma Chem
7 DFE Pharma
2 Finar
13 Gangwal Chemicals
11 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
39 Kerry
4 Kima Chemical
6 Lonza Capsugel
15 Microlex e.U
1 Nanjing Bold Chemical
1 NEWEDGE Overseas
2 Nomisma Healthcare
4 Novo Excipients
5 Pharmatrans-Sanaq
8 Pluviaendo
5 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
25 Roquette
17 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
4 Ulanqab Kema New Material
3 Valens Pharmachem
4 Vasa Pharmachem
2 Vertellus

EXCIPIENTS BY APPLICATIONS

104 Fillers, Diluents & Binders, 72 Coating Systems & Additives, 50 Direct Compression, 46 Disintegrants & Superdisintegrants, 45 Controlled & Modified Release, 43 Thickeners and Stabilizers, 38 Solubilizers, 33 Granulation, 29 Taste Masking, 29 Topical, 25 Lubricants & Glidants, 23 Film Formers & Plasticizers, 22 Parenteral, 22 Co-Processed Excipients, 20 Chewable & Orodispersible Aids, 12 Emulsifying Agents, 10 API Stability Enhancers, 9 Empty Capsules, 8 Surfactant & Foaming Agents, 7 Rheology Modifiers, 5 Coloring Agents, 4 Vegetarian Capsules

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 26 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
26 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 32 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
32 Finished Drug Prices

MARKET PLACE

7 APIs, 1 FDF Dossiers, 1 EXCIPIENTS

marketPlace
7 APIs
1 FDF Dossiers
1 EXCIPIENTS

PATENTS & EXCLUSIVITIES

16 Health Canada Patents

patents
16 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP

otherSolutions
2 EDQM
1 USP

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 85

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

456

FDF Dossiers

177

FDA Orange Book

199

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

49,779,961

Annual Reports (USD Million)

Finished Drug Prices

371 RELATED EXCIPIENT COMPANIES

656EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 99300-78-4, Venlafaxine hcl, Effexor, Efexor, Effexor xr, Dobupal

Molecular Formula

C₁₇H₂₈ClNO₂

Molecular Weight

313.9 g/mol

InChI Key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

FDA UNII

7D7RX5A8MO

A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

1 2D Structure

Venlafaxine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

2.1.3 InChI Key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl

2.2 Other Identifiers

2.2.1 UNII

7D7RX5A8MO

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hcl

2. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

3. Dobupal

4. Efexor

5. Effexor

6. Hydrochloride, Venlafaxine

7. Sila Venlafaxine

8. Sila-venlafaxine

9. Trevilor

10. Vandral

11. Venlafaxine

12. Wy 45,030

13. Wy 45030

14. Wy-45,030

15. Wy-45030

16. Wy45,030

17. Wy45030

2.3.2 Depositor-Supplied Synonyms

1. 99300-78-4

2. Venlafaxine Hcl

3. Effexor

4. Efexor

5. Effexor Xr

6. Dobupal

7. Vandral

8. Venlafaxinehydrochloride

9. Wy-45030

10. Venlafaxine (hydrochloride)

11. Wy 45030

12. Wy-45,030

13. Wy 45030 Hydrochloride

14. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

15. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride

16. Nsc-745751

17. 7d7rx5a8mo

18. Venlafaxine (as Hydrochloride)

19. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol Hydrochloride

20. Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, Hydrochloride

21. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol Hydrochloride

22. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride

23. Chebi:9944

24. Venlafaxine Hydrochloride [usan]

25. Venlafaxine Hydorchloride

26. Unii-7d7rx5a8mo

27. C17h27no2.hcl

28. Venlift

29. Vexor

30. D,l-venlafaxine, Hydrochloride

31. Venlafaxine Ea

32. Venlafaxine Xr

33. Effexor Lp

34. Effexor Xl

35. Efexor Xl

36. Venlafaxine, Hcl

37. Effexor (tn)

38. Venlafaxine Hydrochloride [usan:usp]

39. Venlafaxine Hydro Chloride

40. Dsstox_cid_27397

41. Dsstox_rid_82318

42. Dsstox_gsid_47397

43. Schembl41936

44. Mls001401454

45. Chembl1201066

46. Dtxsid8047397

47. Hy-b0196a

48. Bvf-012

49. Amy32694

50. Bcp21401

51. Dl-venlafaxine Hydrochloride- Bio-x

52. Tox21_302508

53. Tox21_500449

54. Nsc745751

55. S1441

56. Venlafaxine Hydrochloride (jan/usp)

57. Venlafaxine Hydrochloride [mi]

58. Akos000280874

59. Akos016340594

60. Ac-1696

61. Ccg-100979

62. Ccg-213270

63. H13v695

64. Ks-5049

65. Lp00449

66. Nc00229

67. Nsc 745751

68. Pw-4112

69. Venlafaxine Hydrochloride [jan]

70. Venlafaxine Hydrochloride [hsdb]

71. Ncgc00256703-01

72. Ncgc00261134-01

73. Venlafaxine Hydrochloride [mart.]

74. Venlafaxine Hydrochloride [vandf]

75. Bv164514

76. Smr000469154

77. Venlafaxine Hydrochloride [usp-rs]

78. Venlafaxine Hydrochloride [who-dd]

79. Cas-99300-78-4

80. Ft-0642395

81. Sw197609-3

82. V0110

83. Pf-00345408

84. D00821

85. Venlafaxine Hydrochloride [ep Impurity]

86. Venlafaxine Hydrochloride [ep Monograph]

87. Venlafaxine Hydrochloride [orange Book]

88. Venlafaxine Hydrochloride [usp Monograph]

89. A845995

90. Venlafaxine Hydrochloride, >=98% (hplc), Powder

91. Venlafaxine Hydrochloride 100 Microg/ml In Methanol

92. Q27108525

93. Venlafaxine Hydrochloride 100 Microg/ml In Acetonitrile

94. 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol -hcl

95. Venlafaxine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

96. 1-[2-(dimethylamino)-1-(4-methoxyph Enyl)ethyl]cyclohexanol Hydrochloride

97. 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol Hydrochloride

98. Venlafaxine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

99. (+/-)-1-(.alpha.-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol Hydrochloride

100. (rs)-1-(2-dimethylamino-1-(4-methoxyphenyl)ethyl)cyclohexanol Hydrochloride

101. 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-1-cyclohexanol Hydrochloride

102. Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, Hydrochloride (1:1

103. Venlafaxine For System Suitability, European Pharmacopoeia (ep) Reference Standard

104. Venlafaxine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

105. Venlafaxine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

106. Venlafaxine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₈ClNO₂
Molecular Weight	313.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	313.1808568 g/mol
Monoisotopic Mass	313.1808568 g/mol
Topological Polar Surface Area	32.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	279
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Effexor xr
Drug Label	Effexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 150mg base; eq 37.5mg base; eq 75mg base
Market Status	Prescription
Company	Wyeth Pharms

2 of 4
Drug Name	Venlafaxine hydrochloride
PubMed Health	Venlafaxine (By mouth)
Drug Classes	Antidepressant
Drug Label	Venlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Tablet, extended release; Tablet; Capsule, extended release
Route	oral; Oral
Strength	37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

3 of 4
Drug Name	Effexor xr
Drug Label	Effexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or ()-1...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 150mg base; eq 37.5mg base; eq 75mg base
Market Status	Prescription
Company	Wyeth Pharms

4 of 4
Drug Name	Venlafaxine hydrochloride
PubMed Health	Venlafaxine (By mouth)
Drug Classes	Antidepressant
Drug Label	Venlafaxine hydrochloride extended-release capsules for oral administration contain venlafaxine hydrochloride, a structurally novel antidepressant. It is designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride or (c...
Active Ingredient	Venlafaxine hydrochloride
Dosage Form	Tablet, extended release; Tablet; Capsule, extended release
Route	oral; Oral
Strength	37.5mg; eq 100mg base; eq 225mg base; eq 50mg base; 150mg; eq 150mg base; eq 75mg base; 75mg; eq 25mg base; eq 37.5mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Anchen Pharms; Teva; Alembic Pharms; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Osmotica Pharm; Sun Pharma Global; Vintage; Valeant Bermuda; Zydus Pharms Usa; Dr Reddys Labs; Orchid Hlthcare; Mylan; Impax Labs; Heritage Ph

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]

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API Reference Price

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EXPORTS","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"62","totalValueFC":"6323.4","currency":"USD","unitRateINR":"5263.8","date":"01-Dec-2023","totalValueINR":"526379.85","totalValueInUsd":"6323.4","indian_port":"JNPT","hs_no":"29093019","bill_no":"9018660","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"SANTOS","supplierAddress":"DAVIA PRIMARIA 5-D QD 10 MOD.01S\/N-DAIA ZIP CODE 75132-120 \/ANAPOLIS-GO-BRAZIL BRAZIL","customerAddress":"A-201\/202, NAVBHARAT EST.,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE

USFDA APPLICATION NUMBER - 20699

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE

USFDA APPLICATION NUMBER - 20699

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ ...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE

USFDA APPLICATION NUMBER - 20699

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 1...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE

USFDA APPLICATION NUMBER - 22104

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE

USFDA APPLICATION NUMBER - 22104

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 3...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE

USFDA APPLICATION NUMBER - 22104

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 7...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

USFDA APPLICATION NUMBER - 22104

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Venlafaxine HCl

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ACTIVE PHARMA INGREDIENTS

86 API Suppliers

43 USDMF

45 CEP/COS

3 JDMF

24 EU WC

6 KDMF

20 NDC API

29 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

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1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

456 FDF Dossiers

177 FDA Orange Book

199 Europe

48 Canada

7 South Africa

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DRUG PRODUCT COMPOSITIONS

CAPSULE, EXTENDED RELEASE;ORAL - EQ 150MG BASE

CAPSULE, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE

CAPSULE, EXTENDED RELEASE;ORAL - EQ 75MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 150MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 225MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 37.5MG BASE

TABLET, EXTENDED RELEASE;ORAL - EQ 75MG BASE

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