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Vicriviroc

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INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 0

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FDF

2INTERMEDIATES

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Canada

Australia

South Africa

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Chemistry

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Also known as: Sch-d, 306296-47-9, Sch-417690, Vicriviroc [inn], Sch 417690, Sch-d690

Molecular Formula

C₂₈H₃₈F₃N₅O₂

Molecular Weight

533.6 g/mol

InChI Key

CNPVJJQCETWNEU-CYFREDJKSA-N

FDA UNII

TL515DW4QS

Vicriviroc is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. Vicriviroc is designed to bind to CCR5 and inhibit the entry of HIV into CD4 cells.

1 2D Structure

Vicriviroc

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4,6-dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone

2.1.2 InChI

InChI=1S/C28H38F3N5O2/c1-19-16-35(14-15-36(19)24(17-38-5)22-6-8-23(9-7-22)28(29,30)31)27(4)10-12-34(13-11-27)26(37)25-20(2)32-18-33-21(25)3/h6-9,18-19,24H,10-17H2,1-5H3/t19-,24-/m0/s1

2.1.3 InChI Key

CNPVJJQCETWNEU-CYFREDJKSA-N

2.1.4 Canonical SMILES

CC1CN(CCN1C(COC)C2=CC=C(C=C2)C(F)(F)F)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C

2.1.5 Isomeric SMILES

C[C@H]1CN(CCN1[C@@H](COC)C2=CC=C(C=C2)C(F)(F)F)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C

2.2 Other Identifiers

2.2.1 UNII

TL515DW4QS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-((4,6-dimethyl-5-pyrimidinyl)carbonyl)-4-(4-(2-methoxy-4-(trifluoromethyl)phenyl)ethyl-3-methyl-1-piperazinyl)-4-methylpiperidine

2. Sch 417690

3. Sch-417690

4. Sch417690

2.3.2 Depositor-Supplied Synonyms

1. Sch-d

2. 306296-47-9

3. Sch-417690

4. Vicriviroc [inn]

5. Sch 417690

6. Sch-d690

7. (4,6-dimethylpyrimidin-5-yl)-[4-[(3s)-4-[(1r)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone

8. Mk-7690

9. Tl515dw4qs

10. Chembl82301

11. Sch-417690 Free Base

12. Mk-4176

13. Sch417690

14. Sch-d Compound

15. Schd

16. (4,6-dimethylpyrimidin-5-yl)(4-((s)-4-((r)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone

17. (4,6-dimethylpyrimidin-5-yl)-[4-[(3s)-4-[(1r)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-piperazin-1-yl]-4-methyl-1-piperidyl]methanone

18. Vcv

19. Sch-d (old Rn)

20. Pro 140 & Vicrivirac

21. Unii-tl515dw4qs

22. Vicriviroc (sch-417690)

23. Sch-ds

24. Starbld0032646

25. Vicriviroc [mi]

26. Ncgc00182549-01

27. Vicriviroc [who-dd]

28. Mk-4176 Intravaginal Ring

29. Gtpl807

30. 1-((4,6-dimethyl-5-pyrimidinyl)carbonyl)-4-(4-(2-methoxy-4-(trifluoromethyl)phenyl)ethyl-3-methyl-1-piperazinyl)-4-methylpiperidine

31. Schembl118885

32. Chebi:94843

33. Mk-4176 Ivr

34. Dtxsid40897719

35. Bdbm50145685

36. Zinc22010579

37. Db06652

38. 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[4-{2-methoxy-1(r)-4-(trifluoromethyl)-phenyl}ethyl-3(s)-methyl-1-piperazinyl]-4-methylpiperidine

39. 394730-30-4

40. Pro 140 (anti-ccr5 Monoclonal Antibody) & 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[4-{2-methoxy-1(r)-4-(trifluoromethyl)-phenyl}ethyl-3(s)-methyl-1-piperazinyl]-4-methylpiperidine

41. Ab01274747-01

42. Q3557001

43. (4,6-dimethyl-pyrimidin-5-yl)-(4-{(s)-4-[(r)-2-methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidin-1-yl)-methanone

44. 5-((4-((3s)-4-((1r)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)carbonyl)-4,6-dimethylpyrimidine

2.4 Create Date

2005-08-01

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₃₈F₃N₅O₂
Molecular Weight	533.6 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	g/mol
Monoisotopic Mass	g/mol
Topological Polar Surface Area	61.8
Heavy Atom Count	38
Formal Charge	0
Complexity	773
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in HIV infection and viral infection.

5 Pharmacology and Biochemistry

5.1 Metabolism/Metabolites

Metabolised primarily by the CYP3A4 system

Vicriviroc has known human metabolites that include N-Desalkylvicriviroc, O-Desmethylvicriviroc, and Vicriviroc N-oxide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.2 Mechanism of Action

Vicriviroc is a once daily oral inhibitor of CCR5. It noncompetitively binds to a hydrophobic pocket between transmembrance helices by the extracellular side of CCR5. This allosteric antagonism causes a conformational change in the protein preventing binding of gp120 to CCR5. This prevents the entry of HIV into the cell.

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ABOUT THIS PAGE

Vicriviroc Manufacturers

A Vicriviroc manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vicriviroc, including repackagers and relabelers. The FDA regulates Vicriviroc manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vicriviroc API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vicriviroc Suppliers

A Vicriviroc supplier is an individual or a company that provides Vicriviroc active pharmaceutical ingredient (API) or Vicriviroc finished formulations upon request. The Vicriviroc suppliers may include Vicriviroc API manufacturers, exporters, distributors and traders.

Vicriviroc GMP

Vicriviroc Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vicriviroc GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vicriviroc GMP manufacturer or Vicriviroc GMP API supplier for your needs.

Vicriviroc CoA

A Vicriviroc CoA (Certificate of Analysis) is a formal document that attests to Vicriviroc's compliance with Vicriviroc specifications and serves as a tool for batch-level quality control.

Vicriviroc CoA mostly includes findings from lab analyses of a specific batch. For each Vicriviroc CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vicriviroc may be tested according to a variety of international standards, such as European Pharmacopoeia (Vicriviroc EP), Vicriviroc JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vicriviroc USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.