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Vidarabine Monohydrate

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Synopsis

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Chemistry

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Also known as: 24356-66-9, Fa2dm6879k, Ci 673, Vidarabine (usan), (2r,3s,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol hydrate, Vidarabine [usan]

Molecular Formula

C₁₀H₁₅N₅O₅

Molecular Weight

285.26 g/mol

InChI Key

ZTHWFVSEMLMLKT-CAMOTBBTSA-N

FDA UNII

FA2DM6879K

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.

1 2D Structure

Vidarabine Monohydrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrate

2.1.2 InChI

InChI=1S/C10H13N5O4.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10;/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13);1H2/t4-,6-,7+,10-;/m1./s1

2.1.3 InChI Key

ZTHWFVSEMLMLKT-CAMOTBBTSA-N

2.1.4 Canonical SMILES

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N.O

2.1.5 Isomeric SMILES

C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N.O

2.2 Other Identifiers

2.2.1 UNII

FA2DM6879K

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 9 Beta Arabinofuranosyladenine

2. 9 Beta D Arabinofuranosyladenine

3. 9-beta-arabinofuranosyladenine

4. 9-beta-d-arabinofuranosyladenine

5. Adenine Arabinoside

6. Alpha Ara A

7. Alpha D Arabinofuranosyladenine

8. Alpha-ara A

9. Alpha-d-arabinofuranosyladenine

10. Ara A

11. Ara-a

12. Arabinofuranosyladenine

13. Arabinoside, Adenine

14. Arabinosyladenine

15. Beta Ara A

16. Beta-ara A

17. Vidarabine

18. Vira A

19. Vira-a

20. Viraa

2.3.2 Depositor-Supplied Synonyms

1. 24356-66-9

2. Fa2dm6879k

3. Ci 673

4. Vidarabine (usan)

5. (2r,3s,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Hydrate

6. Vidarabine [usan]

7. (2r,3s,4s,5r)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrate

8. Vidarabine [jan]

9. Vidarabine (monohydrate)

10. (2r,3s,4s,5r)-2-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol Hydrate

11. Adenine Arabinofuranoside Hydrate

12. 9-beta-d-arabinofuranosyl-9h-purine-6-amine Monohydrate

13. Drg-0058

14. Unii-fa2dm6879k

15. 9-beta-d-arabinofuranosyladenine Monohydrate

16. Vidarabineh2o

17. Vidarabine H2o

18. Adenine, 9-beta-d-arabinofuranosyl-, Monohydrate

19. Vidarabine [usan:usp:inn:ban:jan]

20. 9h-purin-6-amine, 9-beta-d-arabinofuranosyl-, Monohydrate

21. Vira-a (tn)

22. Vidarabine [vandf]

23. Schembl2929

24. Vidarabine [mart.]

25. Chebi:9978

26. Vidarabine [orange Book]

27. Dtxsid10947210

28. Vidarabine [usp Impurity]

29. 9h-purin-6-amine, 9-.beta.-d-arabinofuranosyl-, Monohydrate

30. Vidarabine Monohydrate [mi]

31. Hy-n6666

32. Mfcd00150980

33. S5297

34. Akos025312428

35. Ccg-267319

36. Nsc 757383

37. Cs-0083211

38. 9-beta-d-arabino Furanosyl Adenine Monohydrate

39. Adenine 9-beta-d-arabinofuranoside Monohydrate

40. C07195

41. D00406

42. T72143

43. Vidarabine (200 Mg)g-2939ug/mg(ai)

44. 9-pentofuranosyl-9h-purin-6-amine--water (1/1)

45. J-015462

46. 9-.beta.-d-arabinofuranosyladenine Monohydrate

47. 9h-purin-6-amine,9-b-d-arabinofuranosyl-,hydrate(1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₅N₅O₅
Molecular Weight	285.26 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Exact Mass	285.10731860 g/mol
Monoisotopic Mass	285.10731860 g/mol
Topological Polar Surface Area	141 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	335
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antimetabolites

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Antimetabolites.)

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

ABOUT THIS PAGE

Vidarabine Monohydrate Manufacturers

A Vidarabine Monohydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vidarabine Monohydrate, including repackagers and relabelers. The FDA regulates Vidarabine Monohydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vidarabine Monohydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vidarabine Monohydrate Suppliers

A Vidarabine Monohydrate supplier is an individual or a company that provides Vidarabine Monohydrate active pharmaceutical ingredient (API) or Vidarabine Monohydrate finished formulations upon request. The Vidarabine Monohydrate suppliers may include Vidarabine Monohydrate API manufacturers, exporters, distributors and traders.

Vidarabine Monohydrate GMP

Vidarabine Monohydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vidarabine Monohydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vidarabine Monohydrate GMP manufacturer or Vidarabine Monohydrate GMP API supplier for your needs.

Vidarabine Monohydrate CoA

A Vidarabine Monohydrate CoA (Certificate of Analysis) is a formal document that attests to Vidarabine Monohydrate's compliance with Vidarabine Monohydrate specifications and serves as a tool for batch-level quality control.

Vidarabine Monohydrate CoA mostly includes findings from lab analyses of a specific batch. For each Vidarabine Monohydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vidarabine Monohydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Vidarabine Monohydrate EP), Vidarabine Monohydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vidarabine Monohydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.