Find Vidofludimus Calcium manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Fw5vy7926x, 1-cyclopentene-1-carboxylic acid, 2-(((3-fluoro-3'-methoxy(1,1'-biphenyl)-4-yl)amino)carbonyl)-, calcium salt (2:1), 1354012-90-0, Unii-fw5vy7926x, Vidofludimus calcium [who-dd]
Molecular Formula
C40H34CaF2N2O8
Molecular Weight
748.8  g/mol
InChI Key
KWSJBFAXOPFZSO-UHFFFAOYSA-L
FDA UNII
FW5VY7926X

Vidofludimus Calcium
Vidofludimus Calcium Anhydrous is the calcium salt form of vidofludimus, an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH), with potential anti-inflammatory, immunomodulating and anti-viral activities. Upon administration, vidofludimus specifically targets, binds to and prevents the activation of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine synthesis, leading to inhibition of transcriptional elongation, cell cycle arrest, and apoptosis in activated lymphocytes. DHODH inhibition also leads to metabolic stress in activated lymphocytes and inhibition of the release of proinflammatory cytokines including interleukin (IL)-17 (IL-17A and IL-17F) and interferon-gamma (IFNg), thereby reducing inflammation. In addition, DHODH inhibition may lead to host-based anti-viral activity against many viruses. DHODH, a mitochondrial enzyme that catalyzes the conversion of dihydroorotate (DHO) to orotate, is a key enzyme in pyrimidine de novo biosynthesis. Metabolically highly activated and rapidly proliferating lymphocytes and various virus infected cells require de novo synthesis to meet their needs for pyrimidines.
1 2D Structure

Vidofludimus Calcium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium;2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylate
2.1.2 InChI
InChI=1S/2C20H18FNO4.Ca/c2*1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25;/h2*2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25);/q;;+2/p-2
2.1.3 InChI Key
KWSJBFAXOPFZSO-UHFFFAOYSA-L
2.1.4 Canonical SMILES
COC1=CC=CC(=C1)C2=CC(=C(C=C2)NC(=O)C3=C(CCC3)C(=O)[O-])F.COC1=CC=CC(=C1)C2=CC(=C(C=C2)NC(=O)C3=C(CCC3)C(=O)[O-])F.[Ca+2]
2.2 Other Identifiers
2.2.1 UNII
FW5VY7926X
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Fw5vy7926x

2. 1-cyclopentene-1-carboxylic Acid, 2-(((3-fluoro-3'-methoxy(1,1'-biphenyl)-4-yl)amino)carbonyl)-, Calcium Salt (2:1)

3. 1354012-90-0

4. Unii-fw5vy7926x

5. Vidofludimus Calcium [who-dd]

2.4 Create Date
2012-04-23
3 Chemical and Physical Properties
Molecular Weight 748.8 g/mol
Molecular Formula C40H34CaF2N2O8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass748.1909132 g/mol
Monoisotopic Mass748.1909132 g/mol
Topological Polar Surface Area157 Ų
Heavy Atom Count53
Formal Charge0
Complexity571
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

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ABOUT THIS PAGE

Vidofludimus Calcium Manufacturers

A Vidofludimus Calcium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vidofludimus Calcium, including repackagers and relabelers. The FDA regulates Vidofludimus Calcium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vidofludimus Calcium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vidofludimus Calcium Suppliers

A Vidofludimus Calcium supplier is an individual or a company that provides Vidofludimus Calcium active pharmaceutical ingredient (API) or Vidofludimus Calcium finished formulations upon request. The Vidofludimus Calcium suppliers may include Vidofludimus Calcium API manufacturers, exporters, distributors and traders.

Vidofludimus Calcium GMP

Vidofludimus Calcium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vidofludimus Calcium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vidofludimus Calcium GMP manufacturer or Vidofludimus Calcium GMP API supplier for your needs.

Vidofludimus Calcium CoA

A Vidofludimus Calcium CoA (Certificate of Analysis) is a formal document that attests to Vidofludimus Calcium's compliance with Vidofludimus Calcium specifications and serves as a tool for batch-level quality control.

Vidofludimus Calcium CoA mostly includes findings from lab analyses of a specific batch. For each Vidofludimus Calcium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vidofludimus Calcium may be tested according to a variety of international standards, such as European Pharmacopoeia (Vidofludimus Calcium EP), Vidofludimus Calcium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vidofludimus Calcium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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