List of Drug Master Files (DMF) of Vilazodone HCl Active Pharmaceutical Ingredient listed on PharmaCompass.com

Vilazodone HCl

Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

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ACTIVE PHARMA INGREDIENTS

21 API Suppliers, 14 USDMF, 5 EU WC, 7 NDC API, 8 Listed Suppliers, $ API Reference Price

21 API Suppliers
14 USDMF
5 EU WC
7 NDC API
8 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

27 FDF Dossiers, 18 FDA Orange Book, 3 Canada, 6 Listed Dossiers

27 FDF Dossiers
18 FDA Orange Book
3 Canada
6 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 10MG, TABLET;ORAL - 20MG, TABLET;ORAL - 40MG

drugProductComposition
TABLET;ORAL - 10MG
TABLET;ORAL - 20MG
TABLET;ORAL - 40MG

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 2 Seqens, 3 DKSH, 8 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 3 Actylis, 1 Aeon Procare, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 BASF, 5 Corel Pharma Chem, 4 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 3 Ideal Cures Pvt Ltd, 20 Kerry, 9 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 9 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

40 Fillers, Diluents & Binders, 20 Coating Systems & Additives, 18 Direct Compression, 15 Thickeners and Stabilizers, 13 Controlled & Modified Release, 13 Lubricants & Glidants, 11 Co-Processed Excipients, 9 Granulation, 8 Topical, 6 Disintegrants & Superdisintegrants, 4 Parenteral, 4 Film Formers & Plasticizers, 4 Solubilizers, 3 Emulsifying Agents, 3 Taste Masking, 2 Chewable & Orodispersible Aids, 2 API Stability Enhancers, 2 Coloring Agents, 1 Rheology Modifiers

DIGITAL CONTENT

8 NEWS #PharmaBuzz

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8 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 3 Finished Drug Prices, 1 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
3 Finished Drug Prices
1 Annual Reports

MARKET PLACE

4 APIs

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4 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 5,172

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

24,476,199

Annual Reports (USD Million)

Finished Drug Prices

111 RELATED EXCIPIENT COMPANIES

178EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 163521-08-2, Vilazodone hcl, Viibryd, Vilazodone (hydrochloride), Emd-68843, Emd 68 843

Molecular Formula

C₂₆H₂₈ClN₅O₂

Molecular Weight

478.0 g/mol

InChI Key

RPZBRGFNBNQSOP-UHFFFAOYSA-N

FDA UNII

U8HTX2GK8J

A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT.

1 2D Structure

Vilazodone Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H

2.1.3 InChI Key

RPZBRGFNBNQSOP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N.Cl

2.2 Other Identifiers

2.2.1 UNII

U8HTX2GK8J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)-1-piperazinyl)-, Hydrochloride (1:1)

2. 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide

3. 68843, Emd

4. Emb 68843

5. Emb-68843

6. Emb68843

7. Emd 68843

8. Hcl, Vilazodone

9. Hydrochloride, Vilazodone

10. Viibryd

11. Vilazodone

12. Vilazodone Hcl

2.3.2 Depositor-Supplied Synonyms

1. 163521-08-2

2. Vilazodone Hcl

3. Viibryd

4. Vilazodone (hydrochloride)

5. Emd-68843

6. Emd 68 843

7. Vilazodone Hydrochloride [usan]

8. 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide Hydrochloride

9. Emd 68843

10. U8htx2gk8j

11. Sb659746-a

12. 163521-08-2 (hcl)

13. Chebi:70705

14. Sb659746a

15. 5-[4-[4-(5-cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide Hydrochloride

16. Sb 659746a

17. Sb-659746a

18. Sb-659746-a

19. Vilazodone Hydrochloride (usan)

20. 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide, Hydrochloride

21. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide Hydrochloride

22. 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)-1-piperazinyl)-, Hydrochloride (1:1)

23. 5-(4-(4-(5-cyano-1h-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide Monohydrochloride

24. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride

25. 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide Hydrochloride

26. Unii-u8htx2gk8j

27. Vilazodonei

28. 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-, Hydrochloride (1:1)

29. Viibryd (tn)

30. Vilazodonehydrochloride

31. Vilazodone Monohydrochloride

32. Schembl867358

33. Chembl1615374

34. Dtxsid80936833

35. Bcp11496

36. Emd68843

37. Mfcd00940014

38. S4259

39. Vilazodone Hydrochloride [mi]

40. Akos024464039

41. Ccg-213313

42. Cs-0549

43. Vilazodone Hydrochloride [mart.]

44. Vilazodone Hydrochloride [vandf]

45. Vilazodone Hydrochloride [who-dd]

46. 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboximidic Acid--hydrogen Chloride (1/1)

47. Ac-25885

48. As-74699

49. Emd 68843;sb659746a

50. Hy-14261

51. Vilazodone Hydrochloride, >=98% (hplc)

52. A3919

53. Sw219887-1

54. V0149

55. Vilazodone Hydrochloride [orange Book]

56. D09699

57. 521v128

58. J-525160

59. Q27139037

60. 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine Hydrochloride

61. 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)piperazine Hydrochloride

62. 1-[4-(5-cyanoindol-3-yl)butyl]4-(2-carbamoyl-benzofuran-5-yl)-piperazine Hydrochloride

63. 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2carboxamide Hydrochloride

64. 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide Hydrochloride

65. 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-ium Chloride

66. Vilazodone Hydrochloride Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₈ClN₅O₂
Molecular Weight	478.0 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	477.1931528 g/mol
Monoisotopic Mass	477.1931528 g/mol
Topological Polar Surface Area	102 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	729
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Viibryd
PubMed Health	Vilazodone (By mouth)
Drug Classes	Antidepressant
Drug Label	VIIBRYD Tablets for oral administration contain polymorph Form IV vilazodone hydrochloride (HCl), a selective serotonin reuptake inhibitor and a 5HT1A receptor partial agonist.Vilazodone HCl is 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)...
Active Ingredient	Vilazodone hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	10mg; 40mg; 20mg
Market Status	Prescription
Company	Forest Labs

2 of 2
Drug Name	Viibryd
PubMed Health	Vilazodone (By mouth)
Drug Classes	Antidepressant
Drug Label	VIIBRYD Tablets for oral administration contain polymorph Form IV vilazodone hydrochloride (HCl), a selective serotonin reuptake inhibitor and a 5HT1A receptor partial agonist.Vilazodone HCl is 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)...
Active Ingredient	Vilazodone hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	10mg; 40mg; 20mg
Market Status	Prescription
Company	Forest Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)

Serotonin 5-HT1 Receptor Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes. (See all compounds classified as Serotonin 5-HT1 Receptor Agonists.)

API SUPPLIERS

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USDMF

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EU WC

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NDC API

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Listed Suppliers

01

Alembic Pharmaceuticals Limited

India

BioProcess International

Not Confirmed

02

Beijing Mesochem Technology

China

BioProcess International

Not Confirmed

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 10MG

USFDA APPLICATION NUMBER - 22567

DOSAGE - TABLET;ORAL - 20MG

USFDA APPLICATION NUMBER - 22567

DOSAGE - TABLET;ORAL - 40MG

USFDA APPLICATION NUMBER - 22567

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Vilazodone HCl Manufacturers | Traders | Suppliers

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List of Drug Master Files (DMF) of Vilazodone HCl Active Pharmaceutical Ingredient listed on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

21 API Suppliers

14 USDMF

5 EU WC

7 NDC API

8 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

27 FDF Dossiers

18 FDA Orange Book

3 Canada

6 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 10MG

TABLET;ORAL - 20MG

TABLET;ORAL - 40MG

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4 DFE Pharma

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EXCIPIENTS BY APPLICATIONS

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18 Direct Compression

15 Thickeners and Stabilizers

13 Controlled & Modified Release

13 Lubricants & Glidants

11 Co-Processed Excipients

9 Granulation

8 Topical

6 Disintegrants & Superdisintegrants

4 Parenteral

4 Film Formers & Plasticizers

4 Solubilizers

3 Emulsifying Agents

3 Taste Masking

2 Chewable & Orodispersible Aids

2 API Stability Enhancers

2 Coloring Agents

1 Rheology Modifiers

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3 Finished Drug Prices

1 Annual Reports

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4 APIs

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 5,172

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