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Chemistry

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Also known as: Vildagliptin, 274901-16-5, (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile, Vildagliptin (2r)-isomer, Schembl671629, Dtxsid301119534
Molecular Formula
C17H25N3O2
Molecular Weight
303.4  g/mol
InChI Key
SYOKIDBDQMKNDQ-JULPFRMLSA-N

Vildagliptin
A pyrrolidine-carbonitrile derivative and potent inhibitor of DIPEPTIDYL PEPTIDASE 4 that is used in the treatment of TYPE 2 DIABETES MELLITUS.
1 2D Structure

Vildagliptin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
2.1.2 InChI
InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m1/s1
2.1.3 InChI Key
SYOKIDBDQMKNDQ-JULPFRMLSA-N
2.1.4 Canonical SMILES
C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
2.1.5 Isomeric SMILES
C1C[C@@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. (2s)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

2. Galvus

3. Nvp Laf237

4. Nvp-laf237

5. Vildagliptin

2.2.2 Depositor-Supplied Synonyms

1. Vildagliptin

2. 274901-16-5

3. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

4. Vildagliptin (2r)-isomer

5. Schembl671629

6. Dtxsid301119534

7. Akos015969326

8. F78360

9. A819091

10. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]-1-oxoethyl]-2-pyrrolidinecarbonitrile

11. (2r)-1-[2-[(3-oxidanyl-1-adamantyl)amino]ethanoyl]pyrrolidine-2-carbonitrile

12. (2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine Carbonitrile; (r)-1-(2-(((1r,3s,5r,7s)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

13. Rel-(2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile

2.2.3 Other Synonyms

1. Jalra

2. Equa

2.3 Create Date
2008-07-11
3 Chemical and Physical Properties
Molecular Weight 303.4 g/mol
Molecular Formula C17H25N3O2
XLogP30.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass303.19467705 g/mol
Monoisotopic Mass303.19467705 g/mol
Topological Polar Surface Area76.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity523
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance. in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control


Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

- as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

- in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control (see sections 4. 4, 4. 5 and 5. 1 for available data on different combinations).


Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

- as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

- in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control (see sections 4. 4, 4. 5 and 5. 1 for available data on different combinations).


Treatment of type II diabetes mellitus


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Dipeptidyl-Peptidase IV Inhibitors

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)


Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)


5.2 ATC Code

A10BH02


A10BH02


A10BH02


A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10B - Blood glucose lowering drugs, excl. insulins

A10BH - Dipeptidyl peptidase 4 (dpp-4) inhibitors

A10BH02 - Vildagliptin


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FORM-11.TL\/BZ\/23\/000176 DT.14\/02\/2023)","address":"12\/8 SARASWATHI AMMAL STREET MARUTHI SEVA NAGAR Contact No: 9177","city":"BANGALORE KARNATAKA","supplier":"MOEHS BCN.S.L.","supplierCountry":"SPAIN","foreign_port":"NA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"650","totalValueFC":"3299.4","currency":"USD","unitRateINR":"54275","date":"08-Mar-2023","totalValueINR":"271375","totalValueInUsd":"3299.4","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"4946902","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"12\/8 SARASWATHI AMMAL STREET MARUTHI SEVA NAGAR Contact No: 9177"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682274600,"product":"VILDAGLIPTIN RE-IMPORT AND REPROCESS AND RE-EXPORT VIDE SB NO.2669726 DT.07.07.2022","address":"PLOT NO. 72, H.NO. 8-2-334\/3 & 4 ROAD NO.5, BANJARA HILLS, Contact N","city":"HYDERABAD","supplier":"VERBEN S A","supplierCountry":"SWITZERLAND","foreign_port":"NA","customer":"SMS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"40.32","actualQuantity":"40.315","unit":"KGS","unitRateFc":"550","totalValueFC":"22496.9","currency":"USD","unitRateINR":"45732.5","date":"24-Apr-2023","totalValueINR":"1843705.74","totalValueInUsd":"22496.9","indian_port":"HYDERABAD AIR","hs_no":"29331999","bill_no":"5644986","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO. 72, H.NO. 8-2-334\/3 & 4 ROAD NO.5, BANJARA HILLS, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693247400,"product":"VILDAGLIPTIN- ARVGT01 AS PER DOCUMENT","address":"SURVEY NO.42, GADDAPOTHARAM,KAZIPA LLY IND AREA, SANGAREDDY DIST GADDAPOTHARAM HYD,","city":"HYDERABAD","supplier":"OMAN PHARM PRODUCTS","supplierCountry":"OMAN","foreign_port":"NA","customer":"TIEFENBACHER API + INGREDIENTS GMBH","customerCountry":"INDIA","quantity":"133.10","actualQuantity":"133.1","unit":"KGS","unitRateFc":"532.3","totalValueFC":"78407.2","currency":"EUR","unitRateINR":"48309.7","date":"29-Aug-2023","totalValueINR":"6494964.963","totalValueInUsd":"78407.2","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"OMAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SURVEY NO.42, GADDAPOTHARAM,KAZIPA LLY IND AREA, SANGAREDDY DIST GADDAPOTHARAM HYD,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1694716200,"product":"RE IMPORT - VILDAGLIPTIN SB NO:3701610 DT: 24.08.2022,EXPORTINV NO. 222310165 DT: 23.08.2022,BATCH NO: VG0070322","address":"26, VANDALUR - KELAMBAKKAM ROAD,","city":"CHENNAI. TAMIL NADU.","supplier":"PHARMANEER DRUG CO LTD","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"VENKATA NARAYANA ACTIVE INGREDIENTS","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"300","totalValueFC":"2940","currency":"USD","unitRateINR":"30505.3","date":"15-Sep-2023","totalValueINR":"244042.65","totalValueInUsd":"2940","indian_port":"Madras Air","hs_no":"29420090","bill_no":"7850685","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"8F, 206,SEC 2,NAN KING E RDTAIPEISDNF TAIWAN","customerAddress":"26, VANDALUR - KELAMBAKKAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695925800,"product":"VILDAGLIPTIN \/DS.017 (RE-IMPORT FOR RE EXPORT TO SHIPPER AFTER REPROCESSING, SUPPLY FREE OF CHARGE) BATCH:SA0100525 (S","address":"107A,VINAY BHAVYA COMPLEX","city":"MUMBAI ,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"INDIA","foreign_port":"ROTTERDAM","customer":"HARMAN FINOCHEM","customerCountry":"INDIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"284","totalValueFC":"72243","currency":"USD","unitRateINR":"23987.1","date":"29-Sep-2023","totalValueINR":"5996762.6","totalValueInUsd":"72243","indian_port":"JNPT","hs_no":"29242990","bill_no":"8068297","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"LICHTSTRASSE 35 CH-4056 BASEL Basel, , SwitzerlandSDNF Switzerland","customerAddress":"107A,VINAY BHAVYA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695925800,"product":"VILDAGLIPTIN\/DS.017 (RE-IMPORT FOR RE EXPORT TO SHIPPER AFTER REPROCESSING, SUPPLY FREE OF CHARGE)BATCH:SA0100813 (S\/B","address":"107A,VINAY BHAVYA COMPLEX","city":"MUMBAI ,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"INDIA","foreign_port":"ROTTERDAM","customer":"HARMAN FINOCHEM","customerCountry":"INDIA","quantity":"475.00","actualQuantity":"475","unit":"KGS","unitRateFc":"284","totalValueFC":"137261.7","currency":"USD","unitRateINR":"23987.1","date":"29-Sep-2023","totalValueINR":"11393848.94","totalValueInUsd":"137261.7","indian_port":"JNPT","hs_no":"29242990","bill_no":"8068297","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"LICHTSTRASSE 35 CH-4056 BASEL Basel, , SwitzerlandSDNF Switzerland","customerAddress":"107A,VINAY BHAVYA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697826600,"product":"VILDAGLIPTIN","address":"2ND FLOOR, SERENE CHAMBERS,","city":"","supplier":"KRKA","supplierCountry":"SLOVENIA","foreign_port":"N\/A","customer":"LAURUS LABS","customerCountry":"INDIA","quantity":"37.00","actualQuantity":"37","unit":"KGS","unitRateFc":"1150.7","totalValueFC":"43072.1","currency":"USD","unitRateINR":"96888.1","date":"21-Oct-2023","totalValueINR":"3584859","totalValueInUsd":"43072.1","indian_port":"Vizag-APIICL SEZ","hs_no":"29339990","bill_no":"1001123","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVENIA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"SKLADISCE SUROVIN, SMARJESKA CESTA6 8501 NOVO MESTO,","customerAddress":"2ND FLOOR, SERENE CHAMBERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698172200,"product":"VILDAGLIPTIN\/DS.017(RE-IMPORT FOR RE EXPORT TO SHIPPER AFTERREPROCESSING, SUPPLY FREE OF CHARGE) BATCH: LSA0100302 (S","address":"107A,VINAY BHAVYA COMPLEX","city":"MUMBAI ,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"INDIA","foreign_port":"ROTTERDAM","customer":"HARMAN FINOCHEM","customerCountry":"INDIA","quantity":"160.95","actualQuantity":"160.95","unit":"KGS","unitRateFc":"284","totalValueFC":"46842.9","currency":"USD","unitRateINR":"24223.1","date":"25-Oct-2023","totalValueINR":"3898703.51","totalValueInUsd":"46842.9","indian_port":"JNPT","hs_no":"29242990","bill_no":"8453090","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"LICHTSTRASSE 35 CH-4056 BASEL Basel, , SwitzerlandSDNF Switzerland","customerAddress":"107A,VINAY BHAVYA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698172200,"product":"VILDAGLIPTIN\/DS.017(RE-IMPORT FOR RE EXPORT TO SHIPPER AFTERREPROCESSING, SUPPLY FREE OF CHARGE) BATCH: LSA0100303 (S","address":"107A,VINAY BHAVYA COMPLEX","city":"MUMBAI ,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"INDIA","foreign_port":"ROTTERDAM","customer":"HARMAN FINOCHEM","customerCountry":"INDIA","quantity":"165.00","actualQuantity":"165","unit":"KGS","unitRateFc":"284","totalValueFC":"48021.6","currency":"USD","unitRateINR":"24223.1","date":"25-Oct-2023","totalValueINR":"3996806.96","totalValueInUsd":"48021.6","indian_port":"JNPT","hs_no":"29242990","bill_no":"8453090","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"LICHTSTRASSE 35 CH-4056 BASEL Basel, , SwitzerlandSDNF Switzerland","customerAddress":"107A,VINAY BHAVYA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701282600,"product":"VILDAGLIPTIN-DS-IN 833109 BATCH-+305300122 (IL\/BD-013510 RC\/BD-0002662 VALID DATE 17\/04\/2026)","address":"SANDOZ HOUSE,8TH FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"ITALY","foreign_port":"BASLE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1219","totalValueFC":"6155.7","currency":"USD","unitRateINR":"102517.9","date":"30-Nov-2023","totalValueINR":"512589.5","totalValueInUsd":"6155.7","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"9007528","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"LICHTSTRASSE 35 , CH-4056 BASEL , Basel, , SwitzerlandSDNF Switzerland","customerAddress":"SANDOZ HOUSE,8TH FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"VILDAGLIPTIN\/DS 16_3 835222 BATCH NO.404120034","address":"SANDOZ HOUSE,8TH FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"NOVARTIS PHARMACEUTICALS CORPORATION","supplierCountry":"ITALY","foreign_port":"BASLE","customer":"NOVARTIS PHARMACEUTICALS CORPORATION","customerCountry":"INDIA","quantity":"162.50","actualQuantity":"162.5","unit":"KGS","unitRateFc":"1219","totalValueFC":"200264.5","currency":"USD","unitRateINR":"103554.1","date":"25-Oct-2024","totalValueINR":"16827533.13","totalValueInUsd":"200264.5","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"6331918","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"BASLE","supplierAddress":"LICHTSTRASSE 35 , CH-4056 BASEL , B asel, Switzerland SDNF Switzerland","customerAddress":"SANDOZ HOUSE,8TH FLOOR,"}]
18-Jan-2021
30-Oct-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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Average Price
(USD/KGS)
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Europe

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Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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Registration Country : Germany

Vildagliptin

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Dosage Form : Tablet

Dosage Strength : 50MG

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Application Number :

Regulatory Info : Registered in EU

Registration Country : Germany

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Regulatory Info : Registered in EU

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Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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Regulatory Info : Registered in EU

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Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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Vildagliptin; Metformin

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Dosage Strength : 50MG; 1000MG

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Approval Date :

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Regulatory Info : Registered in EU

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Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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Brand Name : VILDAGLIPTIN AND METFORMIN THINK

Dosage Form : Film-Coated Tablet

Dosage Strength : 50 mg/1,000 mg

Packaging : 60 UNITS (50+1000) MG -ORAL USE

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Registration Country : Italy

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Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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Vildagliptin; Metformin

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Packaging : 60 UNITS (50+850) MG -ORAL USE

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Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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Registration Country : Italy

Vildagliptin

Brand Name : VILDAGLIPTIN THINKS

Dosage Form : Tablets

Dosage Strength : 50 mg

Packaging : 56 UNITS 50 MG - ORAL USE

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ACCORD HEALTHCARE SLU

United Kingdom
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ACCORD HEALTHCARE SLU

United Kingdom
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Vildagliptin; Metformin

Brand Name : VILDAGLIPTIN METFORMIN HYDROCHLORIDE ACCORD

Dosage Form : Film-Coated Tablet

Dosage Strength : 50 mg/ 1,000 mg

Packaging : 60 UNITS (50+1000) MG -ORAL USE

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Registration Country : Italy

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09

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Vildagliptin

Brand Name : VILDAGLIPTIN DOC

Dosage Form : Tablets

Dosage Strength : 50 mg

Packaging : 56 UNITS 50 MG - ORAL USE

Approval Date :

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Registration Country : Italy

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10

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Vildagliptin

Brand Name : Jalra 50Mg 28 Tablets

Dosage Form : Tablet

Dosage Strength : 50 Mg/Tablet

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Registration Country : Spain

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