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    Finished Dosage Form (FDF) import of Vildagliptin obtained from Indian Custom Trade Statistics

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    Chemistry

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    Also known as: Vildagliptin, 274901-16-5, (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile, Vildagliptin (2r)-isomer, Schembl671629, Dtxsid301119534
    Molecular Formula
    C17H25N3O2
    Molecular Weight
    303.4  g/mol
    InChI Key
    SYOKIDBDQMKNDQ-JULPFRMLSA-N
    Vildagliptin
    A pyrrolidine-carbonitrile derivative and potent inhibitor of DIPEPTIDYL PEPTIDASE 4 that is used in the treatment of TYPE 2 DIABETES MELLITUS.
    1 2D Structure

    Vildagliptin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
    2.1.2 InChI
    InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m1/s1
    2.1.3 InChI Key
    SYOKIDBDQMKNDQ-JULPFRMLSA-N
    2.1.4 Canonical SMILES
    C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
    2.1.5 Isomeric SMILES
    C1C[C@@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. (2s)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

    2. Galvus

    3. Nvp Laf237

    4. Nvp-laf237

    5. Vildagliptin

    2.2.2 Depositor-Supplied Synonyms

    1. Vildagliptin

    2. 274901-16-5

    3. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile

    4. Vildagliptin (2r)-isomer

    5. Schembl671629

    6. Dtxsid301119534

    7. Akos015969326

    8. F78360

    9. A819091

    10. (2r)-1-[2-[(3-hydroxy-1-adamantyl)amino]-1-oxoethyl]-2-pyrrolidinecarbonitrile

    11. (2r)-1-[2-[(3-oxidanyl-1-adamantyl)amino]ethanoyl]pyrrolidine-2-carbonitrile

    12. (2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine Carbonitrile; (r)-1-(2-(((1r,3s,5r,7s)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile

    13. Rel-(2r)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile

    2.2.3 Other Synonyms

    1. Jalra

    2. Equa

    2.3 Create Date
    2008-07-11
    3 Chemical and Physical Properties
    Molecular Weight 303.4 g/mol
    Molecular Formula C17H25N3O2
    XLogP30.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass303.19467705 g/mol
    Monoisotopic Mass303.19467705 g/mol
    Topological Polar Surface Area76.4 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity523
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

    as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance. in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control

    Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

    - as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

    - in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control (see sections 4. 4, 4. 5 and 5. 1 for available data on different combinations).

    Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus:

    - as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance.

    - in combination with other medicinal products for the treatment of diabetes, including insulin, when these do not provide adequate glycaemic control (see sections 4. 4, 4. 5 and 5. 1 for available data on different combinations).

    Treatment of type II diabetes mellitus

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Dipeptidyl-Peptidase IV Inhibitors

    Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)

    Hypoglycemic Agents

    Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

    5.2 ATC Code

    A10BH02

    A10BH02

    A10BH02

    A - Alimentary tract and metabolism

    A10 - Drugs used in diabetes

    A10B - Blood glucose lowering drugs, excl. insulins

    A10BH - Dipeptidyl peptidase 4 (dpp-4) inhibitors

    A10BH02 - Vildagliptin

    API Reference Price

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RD. 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    07-Jan-2021
    30-Sep-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    01

    Alfred E Tiefenbacher GmbH

    Germany
    arrow
    Bio-Europe 2024
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Flag Germany
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    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin

    Brand Name :

    Dosage Form : Tablet

    Dosage Strength : 50MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Tiefenbacher Compnay Banner

    Portfolio PDF

    Product Web Link

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    02

    Alfred E Tiefenbacher GmbH

    Germany
    arrow
    Bio-Europe 2024
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin; Metformin

    Brand Name :

    Dosage Form : Film Coated Tablet

    Dosage Strength : 50MG; 500MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Tiefenbacher Compnay Banner

    Portfolio PDF

    Product Web Link

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    Digital Content

    Website

    Corporate PDF

    03

    Alfred E Tiefenbacher GmbH

    Germany
    arrow
    Bio-Europe 2024
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin; Metformin

    Brand Name :

    Dosage Form : Film Coated Tablet

    Dosage Strength : 50MG; 850MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Tiefenbacher Compnay Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    04

    Alfred E Tiefenbacher GmbH

    Germany
    arrow
    Bio-Europe 2024
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    Alfred E Tiefenbacher GmbH

    Germany
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    Alfred E Tiefenbacher GmbH

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    Alfred E Tiefenbacher GmbH

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Alfred E Tiefenbacher GmbH

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Vildagliptin; Metformin

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    Octavius Pharma Pvt. Ltd

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    Octavius Pharma Pvt. Ltd

    India
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    Virtual BoothOctavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

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    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin

    Brand Name :

    Dosage Form : Tablet

    Dosage Strength : 50MG

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    Regulatory Info : Registered in EU

    Registration Country : Germany

    Tiefenbacher Compnay Banner

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    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Flag Germany
    Virtual Booth Virtual Booth
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    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin; Metformin

    Brand Name :

    Dosage Form : Film Coated Tablet

    Dosage Strength : 50MG; 500MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Registered in EU

    Registration Country : Germany

    Tiefenbacher Compnay Banner

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    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Flag Germany
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    Regulatory Info : Registered in EU

    Registration Country : Germany

    Vildagliptin; Metformin

    Brand Name :

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    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
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    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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    Regulatory Info : Registered in EU

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    Vildagliptin; Metformin

    Brand Name :

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    TOWA PHARMACEUTICAL SPA

    Japan
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    AAPS 2024
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    Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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    Vildagliptin; Metformin

    Brand Name : VILDAGLIPTIN AND METFORMIN THINK

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    Dosage Strength : 50 mg/1,000 mg

    Packaging : 60 UNITS (50+1000) MG -ORAL USE

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    TOWA PHARMACEUTICAL SPA

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    AAPS 2024
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    Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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    Dosage Form : Mg Film-Coated Tablets

    Dosage Strength : 50 mg/850 mg

    Packaging : 60 UNITS (50+850) MG -ORAL USE

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    TOWA PHARMACEUTICAL SPA

    Japan
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    AAPS 2024
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    Virtual BoothTowa Pharma is dedicated to researching, developing, producing, and promoting generic drugs.

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    Vildagliptin

    Brand Name : VILDAGLIPTIN THINKS

    Dosage Form : Tablets

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    Packaging : 56 UNITS 50 MG - ORAL USE

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    DOC GENERICI SRL

    Italy
    AAPS 2024
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    DOC GENERICI SRL

    Italy
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    NOVARTIS EUROPHARM LTD

    Switzerland
    AAPS 2024
    Not Confirmed
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    Vildagliptin; Metformin

    Brand Name : EUCREAS

    Dosage Form : Mg Film-Coated Tablets

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    Novartis Pharma Schweiz AG

    Switzerland
    AAPS 2024
    Not Confirmed
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    Novartis Pharma Schweiz AG

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    Vildagliptinum; Metformini hydrochloridum

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