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Viloxazine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 11 USDMF, 7 NDC API, 6 Listed Suppliers, $ API Reference Price

14 API Suppliers
11 USDMF
7 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

6 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 FDA Orange Book

3 FDF Dossiers
3 FDA Orange Book

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 2 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

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1 US Medicaid Prescriptions

MARKET PLACE

7 APIs

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7 APIs

PATENTS & EXCLUSIVITIES

15 US Patents, 6 US Exclusivities

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15 US Patents
6 US Exclusivities

REF. STANDARDS & IMPURITIES

1 Others

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1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,045,765

Annual Reports (USD Million)

Finished Drug Prices

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Chemistry

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Also known as: 35604-67-2, 2-((2-ethoxyphenoxy)methyl)morpholine hydrochloride, Viloxazine hcl, Vivalan, Emovit, Vicilan

Molecular Formula

C₁₃H₂₀ClNO₃

Molecular Weight

273.75 g/mol

InChI Key

HJOCKFVCMLCPTP-UHFFFAOYSA-N

FDA UNII

OQW30I1332

A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.

1 2D Structure

Viloxazine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(2-ethoxyphenoxy)methyl]morpholine;hydrochloride

2.1.2 InChI

InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H

2.1.3 InChI Key

HJOCKFVCMLCPTP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC1=CC=CC=C1OCC2CNCCO2.Cl

2.2 Other Identifiers

2.2.1 UNII

OQW30I1332

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Emovit

2. Ici-58,834

3. Ici58,834

4. Viloxazine

5. Viloxazine Hydrochloride, (r)-isomer

6. Viloxazine Hydrochloride, (s)-isomer

7. Viloxazine Oxalate (1:1)

8. Viloxazine, (+-)-isomer

9. Viloxazine, (r)-isomer

10. Viloxazine, (s)-isomer

11. Vivalan

2.3.2 Depositor-Supplied Synonyms

1. 35604-67-2

2. 2-((2-ethoxyphenoxy)methyl)morpholine Hydrochloride

3. Viloxazine Hcl

4. Vivalan

5. Emovit

6. Vicilan

7. 2-[(2-ethoxyphenoxy)methyl]morpholine Hydrochloride

8. Rac Viloxazine Hydrochloride

9. Viloxacina Clorhidrato

10. Ici 58,834

11. Viloxazine Hydrochloride [usan]

12. 2-((2-ethoxyphenoxy)methyl)morpholinehydrochloride

13. 2-[(2-ethoxyphenoxy)methyl]morpholine;hydrochloride

14. 2-((o-ethoxyphenoxy)methyl)morpholine Hydrochloride

15. Spn-812

16. Oqw30i1332

17. Qelbree

18. 2-[(2-ethoxy Phenoxy)methyl]morpholine Hydrochloride

19. Morpholine, 2-((2-ethoxyphenoxy)methyl)-, Hydrochloride

20. Morpholine, 2-[(2-ethoxyphenoxy)methyl]-, Hydrochloride

21. Ici-58834

22. Viloxazine Hydrochloride (usan)

23. Ccris 1915

24. Viloxacina Clorhidrato [spanish]

25. Einecs 252-638-6

26. Unii-oqw30i1332

27. Prestwick_734

28. Vivalan (tn)

29. Cloridrato De Viloxazina

30. 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine Hydrochloride

31. Chlorhydrate De Viloxazine

32. 2-(2-ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine Hydrochloride

33. Dsstox_cid_31511

34. Dsstox_rid_97396

35. Dsstox_gsid_57722

36. Schembl300741

37. Chembl2106483

38. Dtxsid8057722

39. Glxc-25714

40. Tox21_113955

41. Viloxazine Hydrochloride [mi]

42. Akos015847050

43. At27980

44. Ccg-220828

45. Viloxazine Hydrochloride [mart.]

46. Ncgc00262964-01

47. Viloxazine Hydrochloride [who-dd]

48. Cas-35604-67-2

49. A6217

50. Ft-0675815

51. Ft-0675816

52. Ft-0675817

53. Ft-0675818

54. Ft-0675819

55. Viloxazine Hydrochloride [orange Book]

56. D02572

57. 2-(o-ethoxyphenoxymethyl)morpholine Hydrochloride

58. 604e672

59. Sr-01000872636

60. Sr-01000872636-1

61. W-110863

62. 2-(2-ethoxy-phenoxymethyl)-morpholine; Hydrochloride

63. 2-[(2-ethoxyphenoxy)-methyl]morpholine Hydrochloride

64. Q27285797

65. 2-(2-ethoxy-phenoxymethyl)-tetra-hydro-1,4-oxazine Hydrochloride

66. (+/-)-morpholine, 2-((2-ethoxyphenoxy)methyl)-, Hydrochloride

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₂₀ClNO₃
Molecular Weight	273.75 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	273.1131712 g/mol
Monoisotopic Mass	273.1131712 g/mol
Topological Polar Surface Area	39.7 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	213
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

Adrenergic Uptake Inhibitors

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Cytochrome P450 2B6 Inhibitors [MoA]; Cytochrome P450 2D6 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]; Cytochrome P450 1A2 Inhibitors [MoA]

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