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Vinblastine Sulfate

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ACTIVE PHARMA INGREDIENTS

16 API Suppliers, 8 USDMF, 5 CEP/COS, 2 JDMF, 1 EU WC, 3 NDC API, 7 Listed Suppliers, $ API Reference Price

16 API Suppliers
8 USDMF
5 CEP/COS
2 JDMF
1 EU WC
3 NDC API
7 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

22 Drugs in Development

22 Drugs in Development

FINISHED DOSAGE FORMULATIONS

25 FDF Dossiers, 7 FDA Orange Book, 5 Europe, 2 Canada, 2 Australia, 4 South Africa, 5 Listed Dossiers

25 FDF Dossiers
7 FDA Orange Book
5 Europe
2 Canada
2 Australia
4 South Africa
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 3 Actylis, 1 Finar

relatedExcipients
1 Nanjing Well Pharmaceutical
3 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

3 Parenteral, 2 Topical, 1 Solubilizers

excipientsByApplications
3 Parenteral
2 Topical
1 Solubilizers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 5 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
5 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices

MARKET PLACE

2 APIs, 2 FDF Dossiers

marketPlace
2 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 4 JP , 1 Others

otherSolutions
3 EDQM
1 USP
4 JP
1 Others

Minakem Vinblastine Sulfate

Synopsis

ACTIVE PHARMA INGREDIENTS

16

API Suppliers

8

USDMF

5

CEP/COS

CEP/COS Certifications

2

JDMF

1

EU WC

0

KDMF

3

NDC API

0

VMF

7

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 108,810

MARKET PLACE

2

API

2

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

25

FDF Dossiers

7

FDA Orange Book

FDA (Orange Book)

5

Europe

2

Canada

2

Australia

4

South Africa

5

Listed Dossiers

22DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

1

USP

4

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

5

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

4,018

Annual Reports (USD Million)

NA

Finished Drug Prices

5 RELATED EXCIPIENT COMPANIES

6EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 143-67-9, Velban, Velsar, Vinblastine (sulfate), Velbe, Exal

Molecular Formula

C₄₆H₆₀N₄O₁₃S

Molecular Weight

909.1 g/mol

InChI Key

KDQAABAKXDWYSZ-PNYVAJAMSA-N

FDA UNII

N00W22YO2B

Vinblastine Sulfate

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

1 2D Structure

Vinblastine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

2.1.2 InChI

InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

2.1.3 InChI Key

KDQAABAKXDWYSZ-PNYVAJAMSA-N

2.1.4 Canonical SMILES

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

N00W22YO2B

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cellblastin

2. Lemblastine

3. Sulfate, Vinblastine

4. Velban

5. Velbe

6. Vinblastin Hexal

7. Vinblastina Lilly

8. Vinblastine

9. Vinblastinsulfat-gry

10. Vincaleukoblastine

2.3.2 Depositor-Supplied Synonyms

1. 143-67-9

2. Velban

3. Velsar

4. Vinblastine (sulfate)

5. Velbe

6. Exal

7. Vlb Monosulfate

8. Alkaban-aq

9. 29060-le

10. Vinblastine Sulphate

11. Vincaleukoblastine,sulfate(1:1)

12. Nsc-49842

13. Mls000863275

14. Vincaleukoblastine, Sulfate (1:1) (salt)

15. N00w22yo2b

16. Belvan, Vlb

17. 29060le

18. Smr000058844

19. Vincaleucoblastine Sulfate

20. Dsstox_cid_27831

21. Dsstox_rid_82594

22. Dsstox_gsid_47853

23. Uniblastin

24. Rozevin Sulfate

25. 29060 Le

26. Cas-18556-44-0

27. Vincaleukoblastine, Sulfate

28. Unii-n00w22yo2b

29. Ccris 2584

30. Vinblastinesulfate

31. Vinblastini Sulfas

32. Chembl378544

33. Ncgc00095285-01

34. Einecs 205-606-0

35. Vinblastine Sulfate [usan:usp:jan]

36. Opera_id_960

37. Ai3-52943

38. Ncgc00181127-01

39. Schembl3549

40. Mls000069550

41. Mls002153253

42. Mls002207069

43. Vinblastine Sulfate [mi]

44. Vinblastine Sulfate [jan]

45. Dtxsid601017133

46. Hms2235e07

47. Hms3403n09

48. Vinblastine Sulfate [iarc]

49. Vinblastine Sulfate [usan]

50. Vinblastine Sulfate [vandf]

51. Vinblastine Sulfate [mart.]

52. Tox21_111498

53. Tox21_112735

54. Ac-821

55. Vinblastine Sulfate [usp-rs]

56. Vinblastine Sulfate [who-dd]

57. Vinblastine Sulfate [who-ip]

58. Akos015960580

59. Tox21_111498_1

60. Tox21_112735_1

61. Cs-1365

62. Ncgc00263548-01

63. Ncgc00344583-01

64. Vinblastine Sulfate [orange Book]

65. Hy-13780

66. Vinblastine Sulfate [ep Monograph]

67. Vinblastini Sulfas [who-ip Latin]

68. Vinblastine Sulfate [usp Monograph]

69. N2255

70. 143v679

71. Sr-01000000155

72. Vinblastine Sulfate Salt, Powder, >=96% (hplc)

73. Sr-01000000155-7

74. Q27077057

75. Vinblastine Sulfate, European Pharmacopoeia (ep) Reference Standard

76. Vinblastine Sulfate, United States Pharmacopeia (usp) Reference Standard

77. Methyl (1r,9r,10s,11r,12r,19r)-11-(acetyloxy)-12-ethyl-4-[(13s,15r,17s)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0?,??.0?,??]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0?,?.0?,?.0??,??]nonadeca-2(7),3,5,13-tetraene-10-carboxylate; Sulfuric Acid

78. Methyl (3ar,3a1r,4r,5s,5ar,10br)-4-acetoxy-3a-ethyl-9-((5s,7r,9s)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2h-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1h-indolizino[8,1-cd]carbazole-5-carboxylate Sulfate

2.3.3 Other Synonyms

1. Vincaleukoblastine Sulfate

2. Vinblastine Sulphate

3. Cellblastin

2.4 Create Date

2005-06-29

3 Chemical and Physical Properties

Molecular Formula	C₄₆H₆₀N₄O₁₃S
Molecular Weight	909.1 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	10
Exact Mass	908.38775915 g/mol
Monoisotopic Mass	908.38775915 g/mol
Topological Polar Surface Area	237 Å²
Heavy Atom Count	64
Formal Charge	0
Complexity	1780
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Vinblastine sulfate
PubMed Health	Vinblastine
Drug Label	Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB...
Active Ingredient	Vinblastine sulfate
Dosage Form	Injectable
Route	Injection
Strength	10mg/vial; 1mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa; Eurohlth Intl

2 of 2
Drug Name	Vinblastine sulfate
PubMed Health	Vinblastine
Drug Label	Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB...
Active Ingredient	Vinblastine sulfate
Dosage Form	Injectable
Route	Injection
Strength	10mg/vial; 1mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa; Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Vinca Alkaloids [CS]; Vinca Alkaloid [EPC]

API SUPPLIERS

01

Minakem

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

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Aspen API

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Fine Chemicals Corporation PTY Ltd

South Africa

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Zeon Pharma Industries India Pvt L...

India

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Minakem

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Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

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Hubei Honch Pharmaceutical

China

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Gedeon Richter

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Medimpex

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Plantex Ltd.

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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