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22 API Suppliers, 11 USDMF, 5 CEP/COS, 2 JDMF, 3 EU WC, 4 NDC API, 9 Listed Suppliers, $ API Reference Price

22 API Suppliers
11 USDMF
5 CEP/COS
2 JDMF
3 EU WC
4 NDC API
9 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

51 FDF Dossiers, 20 FDA Orange Book, 13 Europe, 2 Canada, 2 Australia, 3 South Africa, 11 Listed Dossiers

51 FDF Dossiers
20 FDA Orange Book
13 Europe
2 Canada
2 Australia
3 South Africa
11 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 1 Pfanstiehl, 1 BASF, 2 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
12 SPI Pharma
1 Pfanstiehl
1 BASF
2 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Pluviaendo
3 Roquette
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 9 Direct Compression, 4 Parenteral, 3 Disintegrants & Superdisintegrants, 3 Co-Processed Excipients, 3 Granulation, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

excipientsByApplications
17 Fillers, Diluents & Binders
10 Chewable & Orodispersible Aids
9 Taste Masking
9 Direct Compression
4 Parenteral
3 Disintegrants & Superdisintegrants
3 Co-Processed Excipients
3 Granulation
1 API Stability Enhancers
1 Thickeners and Stabilizers

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13 NEWS #PharmaBuzz

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13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 10 Finished Drug Prices

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2 US Medicaid Prescriptions
10 Finished Drug Prices

MARKET PLACE

6 APIs, 11 FDF Dossiers

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6 APIs
11 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM , 2 USP , 2 JP , 2 Others

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3 EDQM
2 USP
2 JP
2 Others

Vincristine Sulfate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 394,284

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

5,018

Annual Reports (USD Million)

Finished Drug Prices

29 RELATED EXCIPIENT COMPANIES

60EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 2068-78-2, Kyocristine, Vincristine sulphate, Vincrisul, Leurocristine sulfate, Oncovin

Molecular Formula

C₄₆H₅₈N₄O₁₄S

Molecular Weight

923.0 g/mol

InChI Key

AQTQHPDCURKLKT-JKDPCDLQSA-N

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

1 2D Structure

Vincristine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

2.1.2 InChI

InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

2.1.3 InChI Key

AQTQHPDCURKLKT-JKDPCDLQSA-N

2.1.4 Canonical SMILES

CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Cellcristin

2. Citomid

3. Farmistin

4. Leurocristine

5. Oncovin

6. Oncovine

7. Onkocristin

8. Pfs, Vincasar

9. Sulfate, Vincristine

10. Vincasar

11. Vincasar Pfs

12. Vincristin Bristol

13. Vincristin Medac

14. Vincristine

15. Vincrisul

16. Vintec

2.2.2 Depositor-Supplied Synonyms

1. 2068-78-2

2. Kyocristine

3. Vincristine Sulphate

4. Vincrisul

5. Leurocristine Sulfate

6. Oncovin

7. Onkovin

8. Marqibo

9. 22-oxovincaleukoblastine Sulfate

10. Vcr Sulfate

11. Rel-vincristine Sulfate

12. Nsc 67574

13. Lilly 37231

14. Nsc67574

15. Nsc-67574

16. Leurocristine, Sulfate (1:1) (salt)

17. Alkaloid Extracted From Vinca Rosea Linn

18. Novopharm

19. Chebi:79401

20. 1217704-93-2

21. Mls002702994

22. Lilly-37231

23. Vincristini Sulfas

24. Oncovin (lilly)

25. Vincasar (tn)

26. Marqibo (tn)

27. Oncovin (tn)

28. Vincrex (tn)

29. Vincristine, Sulfate

30. Leurocristine, Sulfate

31. Vincristine Sulphate Salt

32. Vincristine Sulfate Liposome

33. Schembl3710

34. Leurocristine Sulfate (1:1)

35. Chembl501867

36. Dtxsid8044331

37. Vincristine Sulfate (jp17/usp)

38. Hms3414l13

39. Hms3678l11

40. Mfcd08706469

41. Akos015895862

42. V0129

43. Lcr

44. Vcr

45. D02197

46. 068v782

47. A936684

48. Methyl (3ar,3a1r,4r,5s,5ar,10br)-4-acetoxy-3a-ethyl-9-((3s,5s,7s,9s)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2h-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1h-indolizino[8,1-cd]carbazole-5-carboxylate Sulfate

2.3 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₄₆H₅₈N₄O₁₄S
Molecular Weight	923.0 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	10
Exact Mass	922.36702371 g/mol
Monoisotopic Mass	922.36702371 g/mol
Topological Polar Surface Area	254 Å²
Heavy Atom Count	65
Formal Charge	0
Complexity	1830
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Marqibo kit
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable, liposomal
Route	Intravenous
Strength	5mg/5ml (1mg/ml)
Market Status	Prescription
Company	Talon Therap

2 of 4
Drug Name	Vincristine sulfate pfs
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Hospira; Teva Pharms Usa

3 of 4
Drug Name	Marqibo kit
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable, liposomal
Route	Intravenous
Strength	5mg/5ml (1mg/ml)
Market Status	Prescription
Company	Talon Therap

4 of 4
Drug Name	Vincristine sulfate pfs
Active Ingredient	Vincristine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml
Market Status	Prescription
Company	Hospira; Teva Pharms Usa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Vinca Alkaloids [CS]; Vinca Alkaloid [EPC]

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API Reference Price

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