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    Chemistry

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    Also known as: 2068-78-2, Kyocristine, Vincristine sulphate, Vincrisul, Leurocristine sulfate, Oncovin
    Molecular Formula
    C46H58N4O14S
    Molecular Weight
    923.0  g/mol
    InChI Key
    AQTQHPDCURKLKT-JKDPCDLQSA-N
    Vincristine Sulfate
    An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
    1 2D Structure

    Vincristine Sulfate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
    2.1.2 InChI
    InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
    2.1.3 InChI Key
    AQTQHPDCURKLKT-JKDPCDLQSA-N
    2.1.4 Canonical SMILES
    CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Cellcristin

    2. Citomid

    3. Farmistin

    4. Leurocristine

    5. Oncovin

    6. Oncovine

    7. Onkocristin

    8. Pfs, Vincasar

    9. Sulfate, Vincristine

    10. Vincasar

    11. Vincasar Pfs

    12. Vincristin Bristol

    13. Vincristin Medac

    14. Vincristine

    15. Vincrisul

    16. Vintec

    2.2.2 Depositor-Supplied Synonyms

    1. 2068-78-2

    2. Kyocristine

    3. Vincristine Sulphate

    4. Vincrisul

    5. Leurocristine Sulfate

    6. Oncovin

    7. Onkovin

    8. Marqibo

    9. 22-oxovincaleukoblastine Sulfate

    10. Vcr Sulfate

    11. Rel-vincristine Sulfate

    12. Nsc 67574

    13. Lilly 37231

    14. Nsc67574

    15. Nsc-67574

    16. Leurocristine, Sulfate (1:1) (salt)

    17. Alkaloid Extracted From Vinca Rosea Linn

    18. Novopharm

    19. Chebi:79401

    20. 1217704-93-2

    21. Mls002702994

    22. Lilly-37231

    23. Vincristini Sulfas

    24. Oncovin (lilly)

    25. Vincasar (tn)

    26. Marqibo (tn)

    27. Oncovin (tn)

    28. Vincrex (tn)

    29. Vincristine, Sulfate

    30. Leurocristine, Sulfate

    31. Vincristine Sulphate Salt

    32. Vincristine Sulfate Liposome

    33. Schembl3710

    34. Leurocristine Sulfate (1:1)

    35. Chembl501867

    36. Dtxsid8044331

    37. Vincristine Sulfate (jp17/usp)

    38. Hms3414l13

    39. Hms3678l11

    40. Mfcd08706469

    41. Akos015895862

    42. V0129

    43. Lcr

    44. Vcr

    45. D02197

    46. 068v782

    47. A936684

    48. Methyl (3ar,3a1r,4r,5s,5ar,10br)-4-acetoxy-3a-ethyl-9-((3s,5s,7s,9s)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2h-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1h-indolizino[8,1-cd]carbazole-5-carboxylate Sulfate

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 923.0 g/mol
    Molecular Formula C46H58N4O14S
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count16
    Rotatable Bond Count10
    Exact Mass922.36702371 g/mol
    Monoisotopic Mass922.36702371 g/mol
    Topological Polar Surface Area254 Ų
    Heavy Atom Count65
    Formal Charge0
    Complexity1830
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMarqibo kit
    Active IngredientVincristine sulfate
    Dosage FormInjectable, liposomal
    RouteIntravenous
    Strength5mg/5ml (1mg/ml)
    Market StatusPrescription
    CompanyTalon Therap

    2 of 4  
    Drug NameVincristine sulfate pfs
    Active IngredientVincristine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml
    Market StatusPrescription
    CompanyHospira; Teva Pharms Usa

    3 of 4  
    Drug NameMarqibo kit
    Active IngredientVincristine sulfate
    Dosage FormInjectable, liposomal
    RouteIntravenous
    Strength5mg/5ml (1mg/ml)
    Market StatusPrescription
    CompanyTalon Therap

    4 of 4  
    Drug NameVincristine sulfate pfs
    Active IngredientVincristine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml
    Market StatusPrescription
    CompanyHospira; Teva Pharms Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antineoplastic Agents, Phytogenic

    Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

    Tubulin Modulators

    Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Vinca Alkaloids [CS]; Vinca Alkaloid [EPC]

    API Reference Price

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D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724437800,"product":"VINCRISTINE SULFATE IP (LIST 3 SR.NO.78)","address":"1101, 11TH FLOOR, DHUKKA CHAMBERS","city":"MUMBAI","supplier":"GUANGDONG JIAHONG COMPANY","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"UNICHEMIE INTERNATIONAL PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"181.5","totalValueFC":"18360.2","currency":"USD","unitRateINR":"15400.3","date":"24-Aug-2024","totalValueINR":"1540027.5","totalValueInUsd":"18360.2","indian_port":"Bombay Air","hs_no":"29398000","bill_no":"5236535","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"18\/F HAIJIAO BUILDING, NO.93 TIANHEROAD,GUANGZHOU,CHINASDNF China","customerAddress":"1101, 11TH FLOOR, DHUKKA CHAMBERS"}]
    13-Jan-2021
    24-Aug-2024
    KGS
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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    ABOUT THIS PAGE

    Vincristine Sulfate Manufacturers

    A Vincristine Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vincristine Sulfate, including repackagers and relabelers. The FDA regulates Vincristine Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vincristine Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Vincristine Sulfate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Vincristine Sulfate Suppliers

    A Vincristine Sulfate supplier is an individual or a company that provides Vincristine Sulfate active pharmaceutical ingredient (API) or Vincristine Sulfate finished formulations upon request. The Vincristine Sulfate suppliers may include Vincristine Sulfate API manufacturers, exporters, distributors and traders.

    click here to find a list of Vincristine Sulfate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Vincristine Sulfate USDMF

    A Vincristine Sulfate DMF (Drug Master File) is a document detailing the whole manufacturing process of Vincristine Sulfate active pharmaceutical ingredient (API) in detail. Different forms of Vincristine Sulfate DMFs exist exist since differing nations have different regulations, such as Vincristine Sulfate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Vincristine Sulfate DMF submitted to regulatory agencies in the US is known as a USDMF. Vincristine Sulfate USDMF includes data on Vincristine Sulfate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Vincristine Sulfate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Vincristine Sulfate suppliers with USDMF on PharmaCompass.

    Vincristine Sulfate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Vincristine Sulfate Drug Master File in Japan (Vincristine Sulfate JDMF) empowers Vincristine Sulfate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Vincristine Sulfate JDMF during the approval evaluation for pharmaceutical products. At the time of Vincristine Sulfate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Vincristine Sulfate suppliers with JDMF on PharmaCompass.

    Vincristine Sulfate CEP

    A Vincristine Sulfate CEP of the European Pharmacopoeia monograph is often referred to as a Vincristine Sulfate Certificate of Suitability (COS). The purpose of a Vincristine Sulfate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Vincristine Sulfate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Vincristine Sulfate to their clients by showing that a Vincristine Sulfate CEP has been issued for it. The manufacturer submits a Vincristine Sulfate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Vincristine Sulfate CEP holder for the record. Additionally, the data presented in the Vincristine Sulfate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Vincristine Sulfate DMF.

    A Vincristine Sulfate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Vincristine Sulfate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Vincristine Sulfate suppliers with CEP (COS) on PharmaCompass.

    Vincristine Sulfate WC

    A Vincristine Sulfate written confirmation (Vincristine Sulfate WC) is an official document issued by a regulatory agency to a Vincristine Sulfate manufacturer, verifying that the manufacturing facility of a Vincristine Sulfate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Vincristine Sulfate APIs or Vincristine Sulfate finished pharmaceutical products to another nation, regulatory agencies frequently require a Vincristine Sulfate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Vincristine Sulfate suppliers with Written Confirmation (WC) on PharmaCompass.

    Vincristine Sulfate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Vincristine Sulfate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Vincristine Sulfate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Vincristine Sulfate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Vincristine Sulfate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Vincristine Sulfate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Vincristine Sulfate suppliers with NDC on PharmaCompass.

    Vincristine Sulfate GMP

    Vincristine Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Vincristine Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vincristine Sulfate GMP manufacturer or Vincristine Sulfate GMP API supplier for your needs.

    Vincristine Sulfate CoA

    A Vincristine Sulfate CoA (Certificate of Analysis) is a formal document that attests to Vincristine Sulfate's compliance with Vincristine Sulfate specifications and serves as a tool for batch-level quality control.

    Vincristine Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Vincristine Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Vincristine Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Vincristine Sulfate EP), Vincristine Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vincristine Sulfate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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