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Chemistry

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Also known as: Thiamin, Vitamin b1, Aneurin, Thiamine ion, Antiberiberi factor, Thiadoxine
Molecular Formula
C12H17N4OS+
Molecular Weight
265.36  g/mol
InChI Key
JZRWCGZRTZMZEH-UHFFFAOYSA-N
FDA UNII
4ABT0J945J

Vitamin B1
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
1 2D Structure

Vitamin B1

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol
2.1.2 InChI
InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1
2.1.3 InChI Key
JZRWCGZRTZMZEH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO
2.2 Other Identifiers
2.2.1 UNII
4ABT0J945J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aneurin

2. Mononitrate, Thiamine

3. Thiamin

4. Thiamine Mononitrate

5. Vitamin B 1

6. Vitamin B1

2.3.2 Depositor-Supplied Synonyms

1. Thiamin

2. Vitamin B1

3. Aneurin

4. Thiamine Ion

5. Antiberiberi Factor

6. Thiadoxine

7. Betaxin

8. 70-16-6

9. Biamine

10. Bequin

11. Thiaminium

12. Thiamine(1+)

13. Thiamine(1+) Ion

14. 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium

15. 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol

16. Thiamine (vit B1)

17. 4abt0j945j

18. Chebi:18385

19. 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium

20. Vib

21. Thd

22. 3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium

23. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-

24. [3h]thiamine

25. [3h]-thiamine

26. Vitamin B 1

27. Nsc36226

28. [3h]vitamin B1

29. 1sbr

30. 3rlb

31. Thoh

32. Prestwick0_000631

33. Prestwick1_000631

34. Prestwick2_000631

35. Prestwick3_000631

36. Bmse000274

37. Timtec1_000613

38. Chembl1547

39. Thiamin; Vitamin B1

40. Unii-4abt0j945j

41. Schembl10075

42. Bspbio_000622

43. Spbio_002841

44. Bpbio1_000686

45. Gtpl4628

46. Gtpl4629

47. Schembl22129283

48. Zinc49153

49. Dtxsid50220251

50. Bdbm50373877

51. Stl301841

52. Akos000668650

53. Db00152

54. 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol

55. 3[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride

56. Smp1_000084

57. Ncgc00017013-06

58. Ncgc00188957-01

59. Ncgc00188957-02

60. C00378

61. Q83187

62. 3-(2-methyl-4-aminopyrimidine-5-ylmethyl)-4-methylthiazolium-5-ethanol

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 265.36 g/mol
Molecular Formula C12H17N4OS+
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass265.11230735 g/mol
Monoisotopic Mass265.11230735 g/mol
Topological Polar Surface Area104 Ų
Heavy Atom Count18
Formal Charge1
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Thiamine is used to prevent and to treat thiamine deficiency syndromes including beriberi, Wernicke's encephalopathy syndrome, delirium, and peripheral neuritis associated with pellagra or neuritis of pregnancy (if associated with severe vomiting).

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)


Although thiamine has not been shown by well-controlled trials to have any therapeutic value, the drug has been used for the management of poor appetite, ulcerative colitis, chronic diarrhea, other GI disorders, and the cerebellar syndrome. Thiamine has also been used orally as an insect repellent, but there is a lack of adequate evidence to establish the efficacy of thiamine for this use.

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)


Low plasma thiamine concentrations have been found in patients with type 1 and type 2 diabetes mellitus. In a small placebo-controlled study, benfotiamine /a related vitamin B1 substance/ 100 mg given four times daily by mouth significantly improved neuropathic pain in patients with diabetic polyneuropathy. /Benfotiamine/

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976-7.


/This study assessed/ the effect of thiamine repletion on thiamine status, functional capacity, and left ventricular ejection fraction (LVEF) in patients with moderate to severe congestive heart failure (CHF) who had received furosemide in doses of 80 mg/d or more for at least 3 months. PATIENTS AND METHODS: Thirty patients were randomized to 1 week of double-blind inpatient therapy with either iv thiamine 200 mg/d or placebo (n = 15 each). All previous drugs were continued. Following discharge, all 30 patients received oral thiamine 200 mg/d as outpatients for 6 weeks. Thiamine status was determined by the erythrocyte thiamine-pyrophosphate effect (TPPE). LVEF was determined by echocardiography. RESULTS: TPPE, diuresis, and LVEF were unchanged with iv placebo. After iv thiamine, TPPE decreased (11.7% +/- 6.5% to 5.4% +/- 3.2%; P < 0.01). LVEF increased (0.28 +/- 0.11 to 0.32 +/- 0.09; P < 0.05), as did diuresis (1,731 +/- 800 mL/d to 2,389 +/- 752 mL/d; P < 0.02), and sodium excretion (84 +/- 52 mEq/d to 116 +/- 83 mEq/d, P < 0.05). In the 27 patients completing the full 7-week intervention, LVEF rose by 22% (0.27 +/- 0.10 to 0.33 +/- 0.11, P < 0.01). CONCLUSIONS: Thiamine repletion can improve left ventricular function and biochemical evidence of thiamine deficiency in some patients with moderate-to-severe CHF who are receiving longterm furosemide therapy.

PMID:7733128 Shimon I et al; Am J Med 98 (5): 485-90 (1995).


For more Therapeutic Uses (Complete) data for Vitamin B1 (11 total), please visit the HSDB record page.


4.2 Drug Warning

Serious hypersensitivity/anaphylactic reactions can occur, especially after repeated administration. Deaths have resulted from IV or IM administration of thiamine.

Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 18


Anaphylaxis as an adverse systemic reaction to thiamine (vitamin B1) has been described in the literature since 1938. Although its precise mechanism is still uncertain, the reaction appears to involve immediate type hypersensitivity and to be exclusively related to parenteral administration...

PMID:9846348 Morinville V et al; Schweiz Med Wochenschr 128 (44): 1743-4 (1998).


Anaphylaxis. There have been occasional reports of serious and even fatal responses to the parenteral administration of thiamin. The clinical characteristics have strongly suggested an anaphylactic reaction. Symptoms associated with thiamin-induced anaphylaxis include anxiety, pruritus, respiratory distress, nausea, abdominal pain, and shock, sometimes progressing to death.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 81, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html


Adverse reactions with thiamine are rare, but hypersensitivity reactions have occurred, mainly after parenteral doses. These reactions have ranged in severity from very mild to, very rarely, fatal anaphylactic shock ... The UK Committee on Safety of Medicines had received, between 1970 and July, 1988, 90 reports of adverse reactions associated with the use of an injection containing high doses of vitamins B and C. The most frequent reactions were anaphylaxis (41 cases, including 2 fatalities), dyspnea or bronchospasm (13 cases), and rash or flushing (22 cases); 78 of the reactions occurred during, or shortly after, intravenous injection and the other 12 after intramuscular injectdion. They recommended that parenteral treatment be used only when essential, and that, when given, facilities for treating anaphylaxis should be available. They also recommended that, when the intravenous route was used, the injection be given slowly (over 10 minutes). Various authors have noted that parenteral treatment is essential for the prophylaxis and treatment of Wernicke's encephalopathy. However, further reports of anaphylaxis to parenteral thiamine have since been described, including one with a fatal outcome.

Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976.


For more Drug Warnings (Complete) data for Vitamin B1 (15 total), please visit the HSDB record page.


4.3 Drug Indication

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells.


5.2 MeSH Pharmacological Classification

Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)


5.3 ATC Code

A - Alimentary tract and metabolism

A11 - Vitamins

A11D - Vitamin b1, plain and in combination with vitamin b6 and b12

A11DA - Vitamin b1, plain

A11DA01 - Thiamine (vit B1)


5.4 Absorption, Distribution and Excretion

Absorption

Absorbed mainly from duodenum, by both active and passive processes


Absorption of thiamin occurs mainly in the jejunum. At low concentrations of thiamin, absorption occurs by an active transport system that involves phosphyrylation; at higher concentrations, absorption occurs by passive diffusion. Only a small percentage of a high dose of thiamin is absorbed, and elevated serum values result in active urinary excretion of the vitamin.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p. 281


Thiamin is transported in blood in both erythrocytes and plasma and is excreted in the urine.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281


Thiamine is absorbed from the small intestine and is phosphorylated in the intestinal mucosa.

Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 89


The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Thiamine is absorbed mainly in the duodenum.

USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 2647


For more Absorption, Distribution and Excretion (Complete) data for Vitamin B1 (8 total), please visit the HSDB record page.


5.5 Metabolism/Metabolites

Hepatic


Converted in vivo to thiamine diphosphate, a coenzyme in the decarboxylation of alpha-keto acids.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1598


Compound 3-(2'-methyl-4'-amino-5'-pyrimidylmethyl)-4-methylthiazole-5-acetic acid, ie thiamine acetic acid, 2-methyl-4-amino-5-formylaminomethylpyrimidine, and 5-(2-hydroxyethyl)-4-methylthiazole have been identified as important metabolites of thiamine, vitamin B1.

The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 248


Biotransformation of thiamine in mammals is generally supposed to /yield/ thiochrome, thiamine disulfide, 5-(2-hydroxyethyl)-4-methyl-thiazole, and some form corresponding to pyrimidine residue of thiamine.

The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 1: A Review of the Literature Published Between 1960 and 1969. London: The Chemical Society, 1970., p. 229


Thiamine is metabolized in the liver of animals. Several urinary metabolites of thiamine have been identified in humans. Little or no unchanged thiamine is excreted in urine following administration of physiologic doses; however, following administration of larger doses, both unchanged thiamine and metabolites are excreted after tissue stores become saturated.

American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)


5.6 Biological Half-Life

The biological half-life of the vitamin is in the range of 9-18 days.

Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281


With higher pharmacological levels, namely repetitive 250-mg amounts taken orally and 500 mg given intramuscularly, nearly 1 week was required for steady state plasma concentrations to be reached; a mean elimination half-life of 1.8 days was estimated.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html


Total thiamin content of the adult human has been estimated to be approximately 30 mg, and the biological half-life of the vitamin is probably in the range of 9 to 18 days.

NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html


5.7 Mechanism of Action

It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to their each unique biological functions.


Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.

PMID:10890024 Cascante M et al; Nutr Cancer 36 (2): 150-4 (2000).


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Octotiamine (Tateyama

Registration Number : 217MF10337

Registrant's Address : 1133 Oe, Imizu City, Toyama Prefecture

Initial Date of Registration : 2005-07-21

Latest Date of Registration : 2010-03-23

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CHINA","customerAddress":"III FLOOR NO.39\/19 ASPEN COURT,R A"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728325800,"product":"VITAMIN B12 USP (CYANOCOBALAMIN)","address":"30 ABHISHEK AVENUE","city":"BHARUCH","supplier":"CSPC PHARMACEUTICAL GROUP","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SANJIVANI PHARMA","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1330","totalValueFC":"134303.4","currency":"USD","unitRateINR":"112850.5","date":"08-Oct-2024","totalValueINR":"11285050","totalValueInUsd":"134303.4","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"6015119","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"NO. 8, WEIER ROAD, NINGJIN SALINIZA TION INDUSTRIAL PARK, XINGTAI, HEBE I, CHINA, P.C. 055550 CHINA","customerAddress":"30 ABHISHEK AVENUE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728412200,"product":"THIAMINE MONONITRATE - GERMANY","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"ROYAL DSM","supplierCountry":"GERMANY","foreign_port":"SINGAPORE","customer":"ROYAL DSM","customerCountry":"INDIA","quantity":"60.00","actualQuantity":"60","unit":"KGS","unitRateFc":"1919","totalValueFC":"1370.3","currency":"INR","unitRateINR":"1919","date":"09-Oct-2024","totalValueINR":"115140","totalValueInUsd":"1370.3","indian_port":"JNPT","hs_no":"29362210","bill_no":"6024277","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLE TREE BUSINESS CITY, Singapore - 117 440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728498600,"product":"THIAMINE MONONITRATE - (FOR MEDICINAL USE) GERMANY","address":"401 4TH FL WINDSOR HOUSE CST RD","city":"MUMBAI, MAHARASHTRA.","supplier":"ROYAL DSM","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"ROYAL DSM","customerCountry":"INDIA","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"1688","totalValueFC":"60266.7","currency":"INR","unitRateINR":"1688","date":"10-Oct-2024","totalValueINR":"5064000","totalValueInUsd":"60266.7","indian_port":"JNPT","hs_no":"29362210","bill_no":"6043277","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"30 PASIR PANJANG ROAD #13-31, MAPLE TREE BUSINESS CITY, Singapore - 117 440, , Singapore Singapore","customerAddress":"401 4TH FL WINDSOR HOUSE CST RD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728844200,"product":"VITAMIN B1 (THIAMINE HYDROCHLORIDE) (NOT FOR MEDICINAL USE)CAS.NO.67-03-8","address":"No 56 and 57 Ponappa Chetty Street","city":"Chennai","supplier":"XINFA PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"RAKSH BIO SCIENCE ","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"31.5","totalValueFC":"159182.1","currency":"USD","unitRateINR":"2675.1","date":"14-Oct-2024","totalValueINR":"13375523.52","totalValueInUsd":"159182.1","indian_port":"Madras Sea","hs_no":"29362210","bill_no":"6109082","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non Pharma","supplierPort":"SHANGHAI","supplierAddress":"EAST OF HUAFENG ROAD, SOUTH OF BEIW KENLI DEVELOPMENT ZONE, DONGYING CITY, SHANDONG, CHINA","customerAddress":"No 56 and 57 Ponappa Chetty Street"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"THIAMINE HYDROCHLORIDE (VITAMIN B1 ) IP\/EP","address":"501-502,AMBA SADAN,","city":"MUMBAI,MAHARASHTRA","supplier":"JIANGXI TIANXIN PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GENERAL IMPORT COMPANY (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"17.5","totalValueFC":"8922.3","currency":"USD","unitRateINR":"1499.4","date":"15-Oct-2024","totalValueINR":"749706.57","totalValueInUsd":"8922.3","indian_port":"JNPT","hs_no":"29362290","bill_no":"6134091","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"TDLEANJIANG INDUSTRIAL ZONE,LEPING, JIANGXI 333300, SDNF CHINA","customerAddress":"501-502,AMBA SADAN,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729103400,"product":"THIAMINE MONONITRATE (VITAMIN B1 MONONITRATE) IP","address":"218\/219, 2ND FLOOR,KAILASH PLAZA,","city":"GHATKOPAR EAST,MUMBAI, MAHARASTHRA","supplier":"BRILLIANT PHARMACEUTICAL LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AQUATIC REMEDIES PVT LTD","customerCountry":"INDIA","quantity":"1400.00","actualQuantity":"1400","unit":"KGS","unitRateFc":"21.5","totalValueFC":"30449.7","currency":"USD","unitRateINR":"1827.6","date":"17-Oct-2024","totalValueINR":"2558579.49","totalValueInUsd":"30449.7","indian_port":"JNPT","hs_no":"29362210","bill_no":"6165714","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F, 32\/F, PLAZA 88 NO, 88 YEU NG UK ROAD TSUEN WAN, NT HONG KONG TSUEN, , HONG KONG HONG KONG","customerAddress":"218\/219, 2ND FLOOR,KAILASH PLAZA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729276200,"product":"VITAMIN B12 1 % SD (CYANOCOBALAMIN VITAMIN B12) ( DUAL USE NOC NUMBER : NOC\/WZ\/2024\/009732.)","address":"C-112, PAWANE, TTC, MIDC,INDUSTRIA","city":"NAVI MUMBAI,MAHARASHTRA","supplier":"N\/A","supplierCountry":"SINGAPORE","foreign_port":"SINGAPORE","customer":"FIRST TIME US PHARMACEUTICALS (INDIA) PRIVATE LIMI","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"250","totalValueFC":"2881.3","currency":"USD","unitRateINR":"24210.8","date":"19-Oct-2024","totalValueINR":"242108","totalValueInUsd":"2881.3","indian_port":"Bombay Air","hs_no":"29362990","bill_no":"6225039","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"N\/A","customerAddress":"C-112, PAWANE, TTC, MIDC,INDUSTRIA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"THIAMINE MONONITRATE (VITAMIN B1 MONONITRATE) IP","address":"2 FLR.PRESTIGE PLAZA","city":"AKOTA BARODA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"AMI LIFESCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"22.5","totalValueFC":"45494.5","currency":"USD","unitRateINR":"1911.4","date":"23-Oct-2024","totalValueINR":"3822750","totalValueInUsd":"45494.5","indian_port":"JNPT","hs_no":"29362210","bill_no":"6295449","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"S LIMITEDOFFICE F,32\/F PLAZA 88 NO. 88YEUNG UK ROAD TSUEN WAN,NT,HONG K ONG CHINA CHINA","customerAddress":"2 FLR.PRESTIGE PLAZA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729621800,"product":"VITAMIN B12 USP (CYANOCOBALAMIN)","address":"30 ABHISHEK AVENUE","city":"BHARUCH","supplier":"CSPC PHARMACEUTICAL GROUP","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SANJIVANI PHARMA","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"1330","totalValueFC":"134303.4","currency":"USD","unitRateINR":"112850.5","date":"23-Oct-2024","totalValueINR":"11285050","totalValueInUsd":"134303.4","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"6291202","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"NO. 8, WEIER ROAD, NINGJIN SALINIZA TION INDUSTRIAL PARK, XINGTAI, HEBE I, CHINA, P.C. 055550 CHINA","customerAddress":"30 ABHISHEK AVENUE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729708200,"product":"VITAMIN B12 IP (CYANOCOBALAMIN) VITAMIN B12 IP (CYANOCOBALAMIN)","address":"42,MAHANT ROAD,3,VILE PARLE","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PRATISTHA PHARMA","customerCountry":"INDIA","quantity":"120.00","actualQuantity":"120","unit":"KGS","unitRateFc":"1340","totalValueFC":"162567.2","currency":"USD","unitRateINR":"113833","date":"24-Oct-2024","totalValueINR":"13659960","totalValueInUsd":"162567.2","indian_port":"ARSHIYA-SEZ\/PANVEL","hs_no":"29362610","bill_no":"6305092","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F,32\/F,PLAZA 88,NO.88 YEUNG UK ROAD, TSUEN WAN NT, HONG KONG SDNF CHINA","customerAddress":"42,MAHANT ROAD,3,VILE PARLE"},{"dataSource":"API 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02-Jan-2021
31-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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01

HOSPIRA

U.S.A
BioFlorida Conference
Not Confirmed
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HOSPIRA

U.S.A
arrow
BioFlorida Conference
Not Confirmed

ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PANTOTHENIC ACID; PHYTONADIONE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN A PALMITATE; VITAMIN E

Brand Name : VITAPED

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : N/A,80MG/VIAL;N/A,0.02MG/VIAL;N/A,0.001MG/VIAL;400 IU/10ML,N/A;N/A,0.14MG/VIAL;N/A,17MG/VIAL;N/A,5MG/VIAL;0.2MG/10ML,N/A;N/A,1MG/VIAL;N/A,1.4MG/VIAL;N/A,1.2MG/VIAL;EQ 2,300 UNITS BASE/10ML,N/A;7 IU/10

Approval Date : 1993-12-29

Application Number : 20176

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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02

SANDOZ CANADA INC

Switzerland
BioFlorida Conference
Not Confirmed
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SANDOZ CANADA INC

Switzerland
arrow
BioFlorida Conference
Not Confirmed

ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K

Brand Name : INFUVITE PEDIATRIC

Dosage Form : INJECTABLE;INTRAVENOUS

Dosage Strength : 80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL

Approval Date : 2001-02-21

Application Number : 21265

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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03

SANDOZ CANADA INC

Switzerland
BioFlorida Conference
Not Confirmed
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SANDOZ CANADA INC

Switzerland
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BioFlorida Conference
Not Confirmed

ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K

Brand Name : INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)

Dosage Form : INJECTABLE;INTRAVENOUS

Dosage Strength : 80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL

Approval Date : 2004-01-29

Application Number : 21265

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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04

TELIGENT

U.S.A
BioFlorida Conference
Not Confirmed
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TELIGENT

U.S.A
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BioFlorida Conference
Not Confirmed

ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN 5-PHOSPHATE SODIUM; THIAMINE; VITAMIN A; VITAMIN E

Brand Name : M.V.I.-12 LYOPHILIZED

Dosage Form : INJECTABLE;INJECTION

Dosage Strength : 100MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;5MCG/VIAL;0.4MG/VIAL;40MG/VIAL;4MG/VIAL;3.6MG/VIAL;3MG/VIAL;1MG/VIAL;10MG/VIAL

Approval Date : 1985-08-08

Application Number : 18933

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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Europe

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01

Abcur AB

United Kingdom
BioFlorida Conference
Not Confirmed
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Abcur AB

United Kingdom
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BioFlorida Conference
Not Confirmed

Thiamine

Brand Name : Tiacur

Dosage Form : Injection fluid, resolution

Dosage Strength : 25 mg/ml

Packaging : Ampoule of glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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02

ANGELINI SpA

Italy
BioFlorida Conference
Not Confirmed
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ANGELINI SpA

Italy
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BioFlorida Conference
Not Confirmed

Vitamin B 12; Thiamine

Brand Name : Dobetin 1000 B1

Dosage Form :

Dosage Strength : 5 Ampoules Im 1 Mg/2 Ml + 25 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

ANGELINI SpA

Italy
BioFlorida Conference
Not Confirmed
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ANGELINI SpA

Italy
arrow
BioFlorida Conference
Not Confirmed

Thiamine; Pyridoxine

Brand Name : Dobetin Total

Dosage Form :

Dosage Strength : 1,000 5 Vials Im + 5 Vials Solv 2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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04

BAYER SpA

Germany
BioFlorida Conference
Not Confirmed
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BAYER SpA

Germany
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BioFlorida Conference
Not Confirmed

Thiamine

Brand Name : Benerva

Dosage Form :

Dosage Strength : 6 Ampoules Im 100 Mg 1 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

Baxter AG

Germany
BioFlorida Conference
Not Confirmed
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Baxter AG

Germany
arrow
BioFlorida Conference
Not Confirmed

Retinolum (Vitamin A); Cholecalciferolum (Vitamin D3); DL-alfa-Tocopherolum (E307); Acidum ascorbicum (Vitamin C; E300); Thiaminum (Vitamin B1); Riboflavinum (Vitamin B2; E101); Pyridoxinum (Vitamin B6); Cyanocobalaminum (Vitamin B12); Acidum folicum; Dexpanthenolum; Biotinum; Nicotinamidum

Brand Name : Cernevit

Dosage Form : Trockensub

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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06

BioFlorida Conference
Not Confirmed
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BioFlorida Conference
Not Confirmed

Vitamin A; Ascorbic Acid; Ergocalciferol; Vitamin E; Thiamine; Riboflavin; Niacin; Pyridoxine; Vitamin B 12; Folic Acid

Brand Name :

Dosage Form : Liquid Solution

Dosage Strength :

Packaging : 1 Bottle- 100 ML, 250 ML

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Portugal

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07

Vefa Ilac

Turkey
BioFlorida Conference
Not Confirmed
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Vefa Ilac

Turkey
arrow
BioFlorida Conference
Not Confirmed

Vitamin A; Thiamine; Riboflavin; Pyridoxine; Vitamin B 12; Ascorbic Acid; Vitamin E; Vitamin D3; Folic Acid; Niacin; Calcium D-pantothenate; Calcium; Copper; Iodine; Iron; Manganese Sulfate; Zinc; Magnesium

Brand Name : Parvulex

Dosage Form : CAPSULE

Dosage Strength :

Packaging : 60 Softgel Capsules

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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08

Vefa Ilac

Turkey
BioFlorida Conference
Not Confirmed
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Vefa Ilac

Turkey
arrow
BioFlorida Conference
Not Confirmed

Vitamin A; Thiamine; Riboflavin; Niacinamide; Pantothenic Acid; Pyridoxine; Biotin; Folic Acid; Vitamin B 12; Ascorbic Acid; Vitamin D3; Vitamin K1; Iodine; Manganese Sulfate; Selenium

Brand Name : Simbavit

Dosage Form : SYRUP

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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09

BioFlorida Conference
Not Confirmed
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BioFlorida Conference
Not Confirmed

Diclofenac Sodium; Thiamine; Pyridoxine; Cobamet

Brand Name :

Dosage Form : CAPSULE

Dosage Strength : 50MG; 50MG; 50MG; 0.25MG

Packaging : 20 Capsules

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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10

CECCARELLI FARMACEUTICI Srl

Country
BioFlorida Conference
Not Confirmed
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CECCARELLI FARMACEUTICI Srl

Country
arrow
BioFlorida Conference
Not Confirmed

Vitamin B 12; Thiamine

Brand Name : Fibronevrina

Dosage Form :

Dosage Strength : 5 Ampoules Im + 5 Vials Solv  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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