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Vitamin E TPGS API

PMC Isochem Isodel TPGS Vitamin E

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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xyz-pharma-m-2024-10-07

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With Fermion, start the journey of your innovative API.

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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xyz-pharma-m-2024-10-07

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 2 USDMF, 4 Listed Suppliers, $ API Reference Price

5 API Suppliers
2 USDMF
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 3 Europe, 3 Listed Dossiers

6 FDF Dossiers
3 Europe
3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 3 DKSH, 2 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 7 Gangwal Healthcare, 1 Aeon Procare, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 5 Corel Pharma Chem, 2 DFE Pharma, 7 Gangwal Chemicals, 3 Ideal Cures Pvt Ltd, 6 Kerry, 8 Microlex e.U, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 9 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

28 Fillers, Diluents & Binders, 21 Coating Systems & Additives, 17 Direct Compression, 12 Controlled & Modified Release, 12 Lubricants & Glidants, 11 Thickeners and Stabilizers, 10 Granulation, 9 Co-Processed Excipients, 7 Disintegrants & Superdisintegrants, 6 Solubilizers, 5 Film Formers & Plasticizers, 4 Taste Masking, 3 Parenteral, 2 Chewable & Orodispersible Aids, 2 Coloring Agents, 1 Emulsifying Agents, 1 API Stability Enhancers, 1 Topical, 1 Rheology Modifiers

DIGITAL CONTENT

7 NEWS #PharmaBuzz

media
7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

globalSalesInformation
2 Finished Drug Prices

MARKET PLACE

6 APIs, 1 EXCIPIENTS

marketPlace
6 APIs
1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 JP , 1 Others

otherSolutions
1 JP
1 Others

TPGS Vitamin E API

Synopsis

ACTIVE PHARMA INGREDIENTS

5

API Suppliers

2

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

4

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 100

MARKET PLACE

6

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

6

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

3

Europe

0

Canada

0

Australia

0

South Africa

3

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

1

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

7

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

88 RELATED EXCIPIENT COMPANIES

153EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)

Molecular Formula

C₃₅H₅₈O₆

Molecular Weight

574.8 g/mol

InChI Key

AOBORMOPSGHCAX-UHFFFAOYSA-N

Vitamin E TPGS API

Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.

1 2D Structure

Vitamin E TPGS API

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate

2.1.2 InChI

InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

2.1.3 InChI Key

AOBORMOPSGHCAX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C

2.2 Synonyms

2.2.1 MeSH Synonyms

1. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

2. Alpha-d-tocopherol Poly(ethylene Glycol) 2000 Succinate

3. Alpha-tocopheryl Polyethylene Glycol Succinate

4. Mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) Succinate Polyethylene Glycol Monoester

5. Poly(oxy-1,2-ethanediyl), Alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-

6. Tocofersolan

7. Tocopherol Poly(ethylene Glycol) 2000 Succinate

8. Tocopherol Polyethylene Glycol Succinate

9. Tocophersolan, (2r-(2r*(4r*,8r*)))-isomer

10. Tocopheryl Poly(ethylene Glycol) 1000 Succinate

11. Tpgs

12. Tpgs 2k

13. Vitamin E-tpgs

14. Vitamine E Peg-1000-succinate

2.2.2 Depositor-Supplied Synonyms

1. Vitamin E Tpgs

2. Tpgs

3. Tocophersolan [usan]

4. Tocofersolan (inn)

5. 30999-06-5

6. Tocophersolan (usan)

7. 1-o-(2-hydroxyethyl) 4-o-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] Butanedioate

8. Tocofersolan [inn]

9. Poly(oxy-1,2-ethanediyl),a-[4-[[(2r)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-2h-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

10. Tocofersolano

11. Tocofersolanum

12. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

13. Tocofersolan, Inn

14. Tocophersolan, Usan

15. Alpha-tocopheryl Polyethylene Glycol Succinate

16. Alpha-tocopheryl Polyethylene Glycol 1000 Succinate

17. Schembl3139787

18. Aquasol E Tpgs Liquid 77iu/ml

19. Dtxsid50860035

20. Chebi:176233

21. Bcp11679

22. Akos015967005

23. Ft-0675259

24. Tocopheryl Polyethylene Glycol 1000 Succinate

25. D06174

26. Q172409

27. D-alpha-tocopheryl Poly(ethylene Glycol) 1000 Succinate

28. D-alpha-tocopheryl Poly(ethylene Glycol)1000 Succinate

29. 1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

30. 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

31. D08cvc;d-(c) Paragraph Sign-tocopherol Polyethylene Glycol 1000 Succinate; Tpgs; Vitamin E-tpgs

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₅H₅₈O₆
Molecular Weight	574.8 g/mol
XLogP3	9.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	20
Exact Mass	574.42333957 g/mol
Monoisotopic Mass	574.42333957 g/mol
Topological Polar Surface Area	82.1 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	768
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

API SUPPLIERS

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USDMF

01

Pmc Isochem

France

Antibody Engineering

Not Confirmed

PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.

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France

Digital Content

Vitamin E Polyethylene Glycol Succinate

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 23823

Submission : 2010-05-20

Status : Active

Type : II

Product Web Link

Digital Content

02

Eastman Chemical Co

U.S.A

Antibody Engineering

Not Confirmed

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Listed Suppliers

01

PMC Isochem

France

Antibody Engineering

Not Confirmed

PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.

Contact Supplier

Contact Supplier

France

Digital Content

TPGS Vitamin E API

About the Company : PMC Isochem is a CDMO company acquired by PMC International in 2017. It manufactures cGMP intermediates, active pharmaceutical ingredients and functional excipients for pharmaceuti...

PMC Isochem is a CDMO company acquired by PMC International in 2017. It manufactures cGMP intermediates, active pharmaceutical ingredients and functional excipients for pharmaceutical and personal care companies worldwide. Its business includes research, product and process development, pilot-scale, industrial production and regulatory approvals support. It adds value to its clients' intellectual property through constant innovation in manufacturing techniques throughout the product life cycle. PMC Isochem's facilities are located within 60 miles of Paris and are all US FDA-audited plants.

Product Web Link

Digital Content

02

Rochem International Inc

U.S.A

Suppliers Night Expo

Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Contact Supplier

U.S.A

Digital Content

TPGS Vitamin E API

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.

Product Web Link

Digital Content

03

Allastir

India

Antibody Engineering

Not Confirmed

04

Matrix Life Science

India

Antibody Engineering

Not Confirmed

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API Reference Price

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