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Vitamin E TPGS API

PMC Isochem Isodel TPGS Vitamin E

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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 2 USDMF, 4 Listed Suppliers, $ API Reference Price

5 API Suppliers
2 USDMF
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 3 Europe, 3 Listed Dossiers

6 FDF Dossiers
3 Europe
3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 3 DKSH, 2 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 7 Gangwal Healthcare, 1 Aeon Procare, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 5 Corel Pharma Chem, 2 DFE Pharma, 7 Gangwal Chemicals, 3 Ideal Cures Pvt Ltd, 6 Kerry, 8 Microlex e.U, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 9 Roquette, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

28 Fillers, Diluents & Binders, 21 Coating Systems & Additives, 17 Direct Compression, 12 Controlled & Modified Release, 12 Lubricants & Glidants, 11 Thickeners and Stabilizers, 10 Granulation, 9 Co-Processed Excipients, 7 Disintegrants & Superdisintegrants, 6 Solubilizers, 5 Film Formers & Plasticizers, 4 Taste Masking, 3 Parenteral, 2 Coloring Agents, 2 Chewable & Orodispersible Aids, 1 Topical, 1 Rheology Modifiers, 1 Emulsifying Agents, 1 API Stability Enhancers

DIGITAL CONTENT

7 NEWS #PharmaBuzz

media
7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

globalSalesInformation
2 Finished Drug Prices

MARKET PLACE

6 APIs, 1 EXCIPIENTS

marketPlace
6 APIs
1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 JP , 1 Others

otherSolutions
1 JP
1 Others

TPGS Vitamin E API

Synopsis

ACTIVE PHARMA INGREDIENTS

5

API Suppliers

2

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

4

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 100

MARKET PLACE

6

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

6

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

3

Europe

0

Canada

0

Australia

0

South Africa

3

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

1

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

7

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

88 RELATED EXCIPIENT COMPANIES

153EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Vitamin e tpgs, Tpgs, Tocophersolan [usan], Tocofersolan (inn), 30999-06-5, Tocophersolan (usan)

Molecular Formula

C₃₅H₅₈O₆

Molecular Weight

574.8 g/mol

InChI Key

AOBORMOPSGHCAX-UHFFFAOYSA-N

Vitamin E TPGS API

Tocophersolan is a water-soluble amphipathic formulation of d-alpha-tocopherol succinate coupled, through a succinate linker, to polyethylene glycol (PEG) 1000. Due to its amphipathic property in which it forms its own micelles, tocophersolan is easily taken up into enterocytes, even in the absence of bile salts; fat soluble d-alpha-tocopherol is then released after hydrolysis. This formulation enhances the absorption of d-alpha-tocopherol compared to the administration of free d-alpha-tocopherol. In addition, tocophersolan may enhance the absorption of water-insoluble agents and other fat-soluble vitamins.

1 2D Structure

Vitamin E TPGS API

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-O-(2-hydroxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate

2.1.2 InChI

InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

2.1.3 InChI Key

AOBORMOPSGHCAX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C

2.2 Synonyms

2.2.1 MeSH Synonyms

1. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

2. Alpha-d-tocopherol Poly(ethylene Glycol) 2000 Succinate

3. Alpha-tocopheryl Polyethylene Glycol Succinate

4. Mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) Succinate Polyethylene Glycol Monoester

5. Poly(oxy-1,2-ethanediyl), Alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-

6. Tocofersolan

7. Tocopherol Poly(ethylene Glycol) 2000 Succinate

8. Tocopherol Polyethylene Glycol Succinate

9. Tocophersolan, (2r-(2r*(4r*,8r*)))-isomer

10. Tocopheryl Poly(ethylene Glycol) 1000 Succinate

11. Tpgs

12. Tpgs 2k

13. Vitamin E-tpgs

14. Vitamine E Peg-1000-succinate

2.2.2 Depositor-Supplied Synonyms

1. Vitamin E Tpgs

2. Tpgs

3. Tocophersolan [usan]

4. Tocofersolan (inn)

5. 30999-06-5

6. Tocophersolan (usan)

7. 1-o-(2-hydroxyethyl) 4-o-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] Butanedioate

8. Tocofersolan [inn]

9. Poly(oxy-1,2-ethanediyl),a-[4-[[(2r)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-2h-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

10. Tocofersolano

11. Tocofersolanum

12. (+)-alpha-tocopheryl Polyethylene Glycol 1000 Succinate

13. Tocofersolan, Inn

14. Tocophersolan, Usan

15. Alpha-tocopheryl Polyethylene Glycol Succinate

16. Alpha-tocopheryl Polyethylene Glycol 1000 Succinate

17. Schembl3139787

18. Aquasol E Tpgs Liquid 77iu/ml

19. Dtxsid50860035

20. Chebi:176233

21. Bcp11679

22. Akos015967005

23. Ft-0675259

24. Tocopheryl Polyethylene Glycol 1000 Succinate

25. D06174

26. Q172409

27. D-alpha-tocopheryl Poly(ethylene Glycol) 1000 Succinate

28. D-alpha-tocopheryl Poly(ethylene Glycol)1000 Succinate

29. 1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

30. 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2h-1-benzopyran-6-yl Butanedioate

31. D08cvc;d-(c) Paragraph Sign-tocopherol Polyethylene Glycol 1000 Succinate; Tpgs; Vitamin E-tpgs

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₅H₅₈O₆
Molecular Weight	574.8 g/mol
XLogP3	9.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	20
Exact Mass	574.42333957 g/mol
Monoisotopic Mass	574.42333957 g/mol
Topological Polar Surface Area	82.1 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	768
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

API SUPPLIERS

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API Reference Price

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CO.LLC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"CONNELL BROS COMPANY (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"295.9","totalValueFC":"14747.9","currency":"USD","unitRateINR":"22796","date":"12-May-2022","totalValueINR":"1139800.65","totalValueInUsd":"14747.9","indian_port":"BOMBAY AIR","hs_no":"29362800","bill_no":"8642237","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZENITH HOUSE.OPP RACE COURSE.,3RD FLR.K KHADYE MARG.MAHALAXMI"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661797800,"product":"TPGS","address":"SAVGAN HEIGHT UNIT B 1003 RTO LANE FOUR BUNGLOW","city":"MUMBAI","supplier":"XI\\'AN HEALTHFUL BIOTECHNOLOGY CO., LTD.","supplierCountry":"CHINA","foreign_port":"NA","customer":"SREDSTVA REGIONALE CHEMIE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"325","totalValueFC":"3288.1","currency":"USD","unitRateINR":"26162.5","date":"30-Aug-2022","totalValueINR":"261625","totalValueInUsd":"3288.1","indian_port":"BOMBAY AIR","hs_no":"29362800","bill_no":"2229254","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SAVGAN HEIGHT UNIT B 1003 RTO LANE FOUR BUNGLOW"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674844200,"product":"VITAMIN E TPGS NF (NON INTENDED FOR FOOD USE)","address":"ZENITH HOUSE.OPP RACE COURSE.,3RD FLR.K KHADYE MARG.MAHALAXMI","city":"MUMBAI,MAHARASHTRA","supplier":"CONNELL USA, LLC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"CONNELL BROS COMPANY (INDIA) PRIVATE 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ISOCHEM","supplierCountry":"FRANCE","foreign_port":"LILLE","customer":"VIATRIS","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"650","totalValueFC":"14397","currency":"EUR","unitRateINR":"60092.5","date":"14-Jun-2024","totalValueINR":"1201850","totalValueInUsd":"14397","indian_port":"Bombay Air","hs_no":"29362500","bill_no":"3996436","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"LILLE","supplierAddress":"32, RUE LAVOISIER VERT LE PETIT, 91710 FranceSDNF France","customerAddress":"564\/A\/22, ROAD NO.92"}]

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ABOUT THIS PAGE

Vitamin E TPGS API Manufacturers

A Vitamin E TPGS API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vitamin E TPGS API, including repackagers and relabelers. The FDA regulates Vitamin E TPGS API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vitamin E TPGS API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Vitamin E TPGS API manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Vitamin E TPGS API Suppliers

A Vitamin E TPGS API supplier is an individual or a company that provides Vitamin E TPGS API active pharmaceutical ingredient (API) or Vitamin E TPGS API finished formulations upon request. The Vitamin E TPGS API suppliers may include Vitamin E TPGS API API manufacturers, exporters, distributors and traders.

click here to find a list of Vitamin E TPGS API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Vitamin E TPGS API USDMF

A Vitamin E TPGS API DMF (Drug Master File) is a document detailing the whole manufacturing process of Vitamin E TPGS API active pharmaceutical ingredient (API) in detail. Different forms of Vitamin E TPGS API DMFs exist exist since differing nations have different regulations, such as Vitamin E TPGS API USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Vitamin E TPGS API DMF submitted to regulatory agencies in the US is known as a USDMF. Vitamin E TPGS API USDMF includes data on Vitamin E TPGS API's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Vitamin E TPGS API USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Vitamin E TPGS API suppliers with USDMF on PharmaCompass.

Vitamin E TPGS API GMP

Vitamin E TPGS API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vitamin E TPGS API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vitamin E TPGS API GMP manufacturer or Vitamin E TPGS API GMP API supplier for your needs.

Vitamin E TPGS API CoA

A Vitamin E TPGS API CoA (Certificate of Analysis) is a formal document that attests to Vitamin E TPGS API's compliance with Vitamin E TPGS API specifications and serves as a tool for batch-level quality control.

Vitamin E TPGS API CoA mostly includes findings from lab analyses of a specific batch. For each Vitamin E TPGS API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vitamin E TPGS API may be tested according to a variety of international standards, such as European Pharmacopoeia (Vitamin E TPGS API EP), Vitamin E TPGS API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vitamin E TPGS API USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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