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Chemistry

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Also known as: 139290-65-6, Mdl 100907, Mdl-100907, M100907, (r)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol, Volinanserin [inn]
Molecular Formula
C22H28FNO3
Molecular Weight
373.5  g/mol
InChI Key
HXTGXYRHXAGCFP-OAQYLSRUSA-N
FDA UNII
EW71EE171J

Volinanserin
Volinanserin is under investigation in clinical trial NCT00464243 (Efficacy and Safety of Volinanserin on Sleep Maintenance Insomnia - Polysomnographic Study).
1 2D Structure

Volinanserin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(R)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol
2.1.2 InChI
InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
2.1.3 InChI Key
HXTGXYRHXAGCFP-OAQYLSRUSA-N
2.1.4 Canonical SMILES
COC1=CC=CC(=C1OC)C(C2CCN(CC2)CCC3=CC=C(C=C3)F)O
2.1.5 Isomeric SMILES
COC1=CC=CC(=C1OC)[C@@H](C2CCN(CC2)CCC3=CC=C(C=C3)F)O
2.2 Other Identifiers
2.2.1 UNII
EW71EE171J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (r)-(2,3-dimethoxyphenyl)(1-(2-(4-fluorophenyl)ethyl)piperidin-4-yl)methanol

2. 4-piperidinemethanol, Alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-, (alpha-r)-

3. Alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenylethyl))-4-piperidine Methanol

4. M100907

5. Mdl 100,907

6. Mdl 100105

7. Mdl 100907

8. Mdl-100,907

9. Mdl-100907

10. Mdl100105

2.3.2 Depositor-Supplied Synonyms

1. 139290-65-6

2. Mdl 100907

3. Mdl-100907

4. M100907

5. (r)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol

6. Volinanserin [inn]

7. Mdl100907

8. Mdl-100,907

9. Mdl100.907

10. (r)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol

11. Chembl74355

12. C22h28fno3

13. Ew71ee171j

14. M-100907

15. Mdl-100.907

16. (r)-(2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol

17. (r)-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine Methanol

18. Mdl 100,907

19. Unii-ew71ee171j

20. Mdl 100009

21. Serotonin 5-ht2 Receptor Antagonists

22. Alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenylethyl))-4-piperidine Methanol

23. Dsstox_cid_27363

24. Dsstox_rid_82298

25. Dsstox_gsid_47363

26. Gtpl185

27. Schembl675164

28. Dtxsid6047363

29. (2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol

30. Zinc598040

31. Ex-a3509

32. Tox21_300244

33. Bdbm50095027

34. Mfcd00909060

35. Akos022180892

36. (r)-(2,3-dimethoxyphenyl)(1-(2-(4-fluorophenyl)ethyl)piperidin-4-yl)methanol

37. Ncgc00247964-01

38. Ncgc00254173-01

39. Ac-36402

40. As-35103

41. Hy-14940

42. Cas-139290-65-6

43. Cs-0003646

44. S0313

45. M100907, >=98% (hplc)

46. A886060

47. Mdl 100907, (r)-(+)-

48. M 100907

49. Q7940202

50. (r)-(1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethoxyphenyl)methanol

51. (r)-(+)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

52. (r)-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2 -(4-fluorophenyl)ethyl]-4-piperinemethanol

53. (r)-(2,3-dimethoxyphenyl)-(1-(2-p-fluorophenylethyl)-piperidine-4-yl)-methanol

54. (r)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

55. 4-piperidinemethanol, Alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-, (+)-

56. 4-piperidinemethanol, Alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (alphar)-

57. (2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol (m 100907)

58. (2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol(mdl 100907)

59. 4-piperidinemethanol, .alpha.-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-, (.alpha.r)-

60. 4-piperidinemethanol, Alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-, (r)-

2.4 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 373.5 g/mol
Molecular Formula C22H28FNO3
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass373.20532192 g/mol
Monoisotopic Mass373.20532192 g/mol
Topological Polar Surface Area41.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity422
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


ABOUT THIS PAGE

Volinanserin Manufacturers

A Volinanserin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Volinanserin, including repackagers and relabelers. The FDA regulates Volinanserin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Volinanserin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Volinanserin Suppliers

A Volinanserin supplier is an individual or a company that provides Volinanserin active pharmaceutical ingredient (API) or Volinanserin finished formulations upon request. The Volinanserin suppliers may include Volinanserin API manufacturers, exporters, distributors and traders.

click here to find a list of Volinanserin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Volinanserin USDMF

A Volinanserin DMF (Drug Master File) is a document detailing the whole manufacturing process of Volinanserin active pharmaceutical ingredient (API) in detail. Different forms of Volinanserin DMFs exist exist since differing nations have different regulations, such as Volinanserin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Volinanserin DMF submitted to regulatory agencies in the US is known as a USDMF. Volinanserin USDMF includes data on Volinanserin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Volinanserin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Volinanserin suppliers with USDMF on PharmaCompass.

Volinanserin GMP

Volinanserin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Volinanserin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Volinanserin GMP manufacturer or Volinanserin GMP API supplier for your needs.

Volinanserin CoA

A Volinanserin CoA (Certificate of Analysis) is a formal document that attests to Volinanserin's compliance with Volinanserin specifications and serves as a tool for batch-level quality control.

Volinanserin CoA mostly includes findings from lab analyses of a specific batch. For each Volinanserin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Volinanserin may be tested according to a variety of international standards, such as European Pharmacopoeia (Volinanserin EP), Volinanserin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Volinanserin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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