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Chemistry

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Also known as: 1013920-15-4, Vorolanib [inn], Yp8g3i74el, Cm082, N-[(3s)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, X-82
Molecular Formula
C23H26FN5O3
Molecular Weight
439.5  g/mol
InChI Key
KMIOJWCYOHBUJS-HAKPAVFJSA-N
FDA UNII
YP8G3I74EL

Vorolanib
Vorolanib is an orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. Vorolanib inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. Vorolanib has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.
1 2D Structure

Vorolanib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3S)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
2.1.2 InChI
InChI=1S/C23H26FN5O3/c1-12-19(10-17-16-9-14(24)5-6-18(16)27-21(17)30)25-13(2)20(12)22(31)26-15-7-8-29(11-15)23(32)28(3)4/h5-6,9-10,15,25H,7-8,11H2,1-4H3,(H,26,31)(H,27,30)/b17-10-/t15-/m0/s1
2.1.3 InChI Key
KMIOJWCYOHBUJS-HAKPAVFJSA-N
2.1.4 Canonical SMILES
CC1=C(NC(=C1C(=O)NC2CCN(C2)C(=O)N(C)C)C)C=C3C4=C(C=CC(=C4)F)NC3=O
2.1.5 Isomeric SMILES
CC1=C(NC(=C1C(=O)N[C@H]2CCN(C2)C(=O)N(C)C)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O
2.2 Other Identifiers
2.2.1 UNII
YP8G3I74EL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cm082

2. N-((3s)-1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide

2.3.2 Depositor-Supplied Synonyms

1. 1013920-15-4

2. Vorolanib [inn]

3. Yp8g3i74el

4. Cm082

5. N-[(3s)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide

6. X-82

7. (s,z)-n-(1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide

8. 1h-pyrrole-3-carboxamide, N-((3s)-1-((dimethylamino)carbonyl)-3-pyrrolidinyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-

9. N-((3s)-1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide

10. Unii-yp8g3i74el

11. Vorolanib [who-dd]

12. Schembl2439528

13. Chembl4297587

14. Gtpl11618

15. Eyp-1901

16. Cm-082

17. S6843

18. Db15247

19. Example 8 [wo2008033562a2]

20. Ac-35712

21. Hy-109019

22. Cs-0030517

23. X-082

24. Q27294638

2.4 Create Date
2012-08-20
3 Chemical and Physical Properties
Molecular Weight 439.5 g/mol
Molecular Formula C23H26FN5O3
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass439.20196787 g/mol
Monoisotopic Mass439.20196787 g/mol
Topological Polar Surface Area97.5 Ų
Heavy Atom Count32
Formal Charge0
Complexity803
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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Looking for 1013920-15-4 / Vorolanib API manufacturers, exporters & distributors?

Vorolanib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vorolanib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vorolanib manufacturer or Vorolanib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vorolanib manufacturer or Vorolanib supplier.

PharmaCompass also assists you with knowing the Vorolanib API Price utilized in the formulation of products. Vorolanib API Price is not always fixed or binding as the Vorolanib Price is obtained through a variety of data sources. The Vorolanib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vorolanib

Synonyms

1013920-15-4, Vorolanib [inn], Yp8g3i74el, Cm082, N-[(3s)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, X-82

Cas Number

1013920-15-4

Unique Ingredient Identifier (UNII)

YP8G3I74EL

About Vorolanib

Vorolanib is an orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. Vorolanib inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. Vorolanib has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.

Vorolanib Manufacturers

A Vorolanib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vorolanib, including repackagers and relabelers. The FDA regulates Vorolanib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vorolanib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vorolanib Suppliers

A Vorolanib supplier is an individual or a company that provides Vorolanib active pharmaceutical ingredient (API) or Vorolanib finished formulations upon request. The Vorolanib suppliers may include Vorolanib API manufacturers, exporters, distributors and traders.

Vorolanib GMP

Vorolanib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vorolanib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vorolanib GMP manufacturer or Vorolanib GMP API supplier for your needs.

Vorolanib CoA

A Vorolanib CoA (Certificate of Analysis) is a formal document that attests to Vorolanib's compliance with Vorolanib specifications and serves as a tool for batch-level quality control.

Vorolanib CoA mostly includes findings from lab analyses of a specific batch. For each Vorolanib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vorolanib may be tested according to a variety of international standards, such as European Pharmacopoeia (Vorolanib EP), Vorolanib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vorolanib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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